The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells

The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells

Inhibitor of differentiation 1 (ID1) is highly expressed in glioblastoma stem cells (GSCs). However, the regulatory mechanism responsible for its role in GSCs is poorly understood. Here, we report that ID1 activates GSC proliferation, self-renewal, and tumorigenicity by suppressing CULLIN3 ubiquitin...

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Bibliographic Details
Main Authors: Xun Jin, Hye-Min Jeon, Xiong Jin, Eun-Jung Kim, Jinlong Yin, Hee-Young Jeon, Young-Woo Sohn, Se-Yeong Oh, Jun-Kyum Kim, Sung-Hak Kim, Ji-Eun Jung, Sungwook Kwak, Kai-Fu Tang, Yunsheng Xu, Jeremy N. Rich, Hyunggee Kim
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Subjects:
CULLIN3
DVL2
GLI2
glioblastoma stem cells
ID1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716308610

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