Drosophila as a model system to unravel the layers of innate immunity to infection
Summary Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
The Royal Society
2012-01-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.120075 |
| _version_ | 1818873572379066368 |
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| author | Ilias Kounatidis Petros Ligoxygakis |
| author_facet | Ilias Kounatidis Petros Ligoxygakis |
| author_sort | Ilias Kounatidis |
| collection | DOAJ |
| description | Summary
Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about innate immunity and host–pathogen interactions. Here, we review current research in the field, encompassing all layers of defence from the role of the microbiota to systemic immune activation, and attempt to speculate on future directions and open questions. |
| first_indexed | 2024-12-19T12:56:50Z |
| format | Article |
| id | doaj.art-6e64958a724a48f881c80eca4627bd30 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-19T12:56:50Z |
| publishDate | 2012-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-6e64958a724a48f881c80eca4627bd302022-12-21T20:20:22ZengThe Royal SocietyOpen Biology2046-24412012-01-012510.1098/rsob.120075120075Drosophila as a model system to unravel the layers of innate immunity to infectionIlias KounatidisPetros LigoxygakisSummary Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about innate immunity and host–pathogen interactions. Here, we review current research in the field, encompassing all layers of defence from the role of the microbiota to systemic immune activation, and attempt to speculate on future directions and open questions.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.120075innate immunitydrosophilahost defence |
| spellingShingle | Ilias Kounatidis Petros Ligoxygakis Drosophila as a model system to unravel the layers of innate immunity to infection Open Biology innate immunity drosophila host defence |
| title | Drosophila as a model system to unravel the layers of innate immunity to infection |
| title_full | Drosophila as a model system to unravel the layers of innate immunity to infection |
| title_fullStr | Drosophila as a model system to unravel the layers of innate immunity to infection |
| title_full_unstemmed | Drosophila as a model system to unravel the layers of innate immunity to infection |
| title_short | Drosophila as a model system to unravel the layers of innate immunity to infection |
| title_sort | drosophila as a model system to unravel the layers of innate immunity to infection |
| topic | innate immunity drosophila host defence |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.120075 |
| work_keys_str_mv | AT iliaskounatidis drosophilaasamodelsystemtounravelthelayersofinnateimmunitytoinfection AT petrosligoxygakis drosophilaasamodelsystemtounravelthelayersofinnateimmunitytoinfection |