Role of hypothalamic-pituitary-adrenal-axis in affective disorders: Anti-depressant and anxiolytic activity of partial 5-HT1A agonist in adrenalectomised rats
Background: Depression is a neurological disorder characterized by sad mood, loss of pleasure, agitation and retardation. Though most relevant neuronal pathophysiology is characterized by decrease in monoamine namely; serotonin (5-HT), dopamine, noradrenaline level in central areas regulating mood a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2013-01-01
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| Series: | Indian Journal of Psychological Medicine |
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| Online Access: | http://www.ijpm.info/article.asp?issn=0253-7176;year=2013;volume=35;issue=3;spage=290;epage=298;aulast=Gupta |
| _version_ | 1818348282654490624 |
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| author | Deepali Gupta Mahesh Radhakrishnan Shvetank Bhatt Yeshwant Kurhe |
| author_facet | Deepali Gupta Mahesh Radhakrishnan Shvetank Bhatt Yeshwant Kurhe |
| author_sort | Deepali Gupta |
| collection | DOAJ |
| description | Background: Depression is a neurological disorder characterized by sad mood, loss of pleasure, agitation and retardation. Though most relevant neuronal pathophysiology is characterized by decrease in monoamine namely; serotonin (5-HT), dopamine, noradrenaline level in central areas regulating mood and behavior, it inadequately explains the exact mechanism involved. Buspirone (BUS), a partial 5-HT 1A receptor agonist has shown promising anti-depressant and anxiolytic properties in various pre-clinical and clinical studies, but the molecular and cellular mechanisms are still unclear. Objective: The aim of this study was to investigate, in vivo, the role of hypothalamic-pituitary-adrenal (HPA) axis dysregulation in pathophysiology of depression-related disorders and the anti-depressant like activity of BUS. To simulate HPA axis dysregulation, rats were subjected to bilateral adrenalectomy (ADX). Materials and Methods: We have analyzed effect of BUS
(10 mg/kg, i.p.) in ADX and sham rats using open field, sucrose consumption, elevated plus maze and hyper-emotionality tests.
Results: In all animal models tested, ADX rats exhibited significant depressive and anxiogenic states while BUS was effective in reversing the psychological diseased condition developed. Conclusion: Taken together, these data showed a prominent role of HPA axis in depression and neuronal mechanism of BUS as anti-depressant and anxiolytic agent. Moreover, our findings suggest that BUS can be a better candidate for stress related depression and anxiety. |
| first_indexed | 2024-12-13T17:47:35Z |
| format | Article |
| id | doaj.art-6e68ef888bc049a791536ba65fda12a1 |
| institution | Directory Open Access Journal |
| issn | 0253-7176 |
| language | English |
| last_indexed | 2024-12-13T17:47:35Z |
| publishDate | 2013-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Psychological Medicine |
| spelling | doaj.art-6e68ef888bc049a791536ba65fda12a12022-12-21T23:36:34ZengSAGE PublishingIndian Journal of Psychological Medicine0253-71762013-01-0135329029810.4103/0253-7176.119501Role of hypothalamic-pituitary-adrenal-axis in affective disorders: Anti-depressant and anxiolytic activity of partial 5-HT1A agonist in adrenalectomised ratsDeepali GuptaMahesh RadhakrishnanShvetank BhattYeshwant KurheBackground: Depression is a neurological disorder characterized by sad mood, loss of pleasure, agitation and retardation. Though most relevant neuronal pathophysiology is characterized by decrease in monoamine namely; serotonin (5-HT), dopamine, noradrenaline level in central areas regulating mood and behavior, it inadequately explains the exact mechanism involved. Buspirone (BUS), a partial 5-HT 1A receptor agonist has shown promising anti-depressant and anxiolytic properties in various pre-clinical and clinical studies, but the molecular and cellular mechanisms are still unclear. Objective: The aim of this study was to investigate, in vivo, the role of hypothalamic-pituitary-adrenal (HPA) axis dysregulation in pathophysiology of depression-related disorders and the anti-depressant like activity of BUS. To simulate HPA axis dysregulation, rats were subjected to bilateral adrenalectomy (ADX). Materials and Methods: We have analyzed effect of BUS (10 mg/kg, i.p.) in ADX and sham rats using open field, sucrose consumption, elevated plus maze and hyper-emotionality tests. Results: In all animal models tested, ADX rats exhibited significant depressive and anxiogenic states while BUS was effective in reversing the psychological diseased condition developed. Conclusion: Taken together, these data showed a prominent role of HPA axis in depression and neuronal mechanism of BUS as anti-depressant and anxiolytic agent. Moreover, our findings suggest that BUS can be a better candidate for stress related depression and anxiety.http://www.ijpm.info/article.asp?issn=0253-7176;year=2013;volume=35;issue=3;spage=290;epage=298;aulast=Gupta5-HT 1A partial agonistadrenalectomydepression |
| spellingShingle | Deepali Gupta Mahesh Radhakrishnan Shvetank Bhatt Yeshwant Kurhe Role of hypothalamic-pituitary-adrenal-axis in affective disorders: Anti-depressant and anxiolytic activity of partial 5-HT1A agonist in adrenalectomised rats Indian Journal of Psychological Medicine 5-HT 1A partial agonist adrenalectomy depression |
| title | Role of hypothalamic-pituitary-adrenal-axis in affective disorders: Anti-depressant and anxiolytic activity of partial 5-HT1A agonist in adrenalectomised rats |
| title_full | Role of hypothalamic-pituitary-adrenal-axis in affective disorders: Anti-depressant and anxiolytic activity of partial 5-HT1A agonist in adrenalectomised rats |
| title_fullStr | Role of hypothalamic-pituitary-adrenal-axis in affective disorders: Anti-depressant and anxiolytic activity of partial 5-HT1A agonist in adrenalectomised rats |
| title_full_unstemmed | Role of hypothalamic-pituitary-adrenal-axis in affective disorders: Anti-depressant and anxiolytic activity of partial 5-HT1A agonist in adrenalectomised rats |
| title_short | Role of hypothalamic-pituitary-adrenal-axis in affective disorders: Anti-depressant and anxiolytic activity of partial 5-HT1A agonist in adrenalectomised rats |
| title_sort | role of hypothalamic pituitary adrenal axis in affective disorders anti depressant and anxiolytic activity of partial 5 ht1a agonist in adrenalectomised rats |
| topic | 5-HT 1A partial agonist adrenalectomy depression |
| url | http://www.ijpm.info/article.asp?issn=0253-7176;year=2013;volume=35;issue=3;spage=290;epage=298;aulast=Gupta |
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