Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus.
<b>BACKGROUND</b> : The role of adipocyte hormones in modulating insulin sensitivity and glucose tolerance are of increasing interest and importance in studies of type 2 diabetes mellitus. Recently a unique signaling molecule, resistin, has been proposed as playing a role in the pathogen...
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| Format: | Article |
| Language: | English |
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King Faisal Specialist Hospital and Research Centre
2005-01-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2005;volume=25;issue=4;spage=283;epage=287;aulast=Al-Harithy |
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| author | Al-Harithy Rowyda Al-Ghamdi Shareefa |
| author_facet | Al-Harithy Rowyda Al-Ghamdi Shareefa |
| author_sort | Al-Harithy Rowyda |
| collection | DOAJ |
| description | <b>BACKGROUND</b> : The role of adipocyte hormones in modulating insulin sensitivity and glucose tolerance are of increasing interest and importance in studies of type 2 diabetes mellitus. Recently a unique signaling molecule, resistin, has been proposed as playing a role in the pathogenesis of obesity-related insulin resistance, but its relevance to human diabetes remains uncertain. Therefore, we assessed the relationship between serum resistin concentrations and insulin resistance in lean, overweight and obese (OW/OB) non-diabetic and diabetic Saudi women. <b>SUBJECTS AND METHODS</b> : We measured fasting serum resistin levels in 44 diabetic women with a mean body mass index (BMI) of 31.82±4.35 kg/m2, 21 OW/OB non-diabetic women with a mean BMI 30.71±3.42 kg/m2 and in 24 lean women with a mean BMI of 23.33±1.24 kg/m2. Insulin resistance was assessed using the homeostasis model assessment for insulin resistance formula derived from fasting insulin and glucose levels. <b>RESULTS</b> : The concentrations of fasting serum resistin showed significant differences among the three groups (<i>P</i>< 0.001). Mean serum resistin concentrations increased from lean (11.59± 2.08) to OW/OB non-diabetic (16.29±2.29) to diabetic (19.42±3.60 ng/mL) women. Significantly higher levels of glucose (<i>P</i>< 0.001) and values for the homeostasis model assessment ratio (HOMA-R) (<i>P</i>< 0.01) occurred in the diabetic compared to the lean and OW/OB non-diabetic subjects. Furthermore, resistin correlated significantly and positively with hip circumferences (r=0.39, <i>P</i>=0.039), weight (r=0.51, <i>P</i>=0.005), insulin (r=0.40, <i>P</i>=0.033), HOMA-R (r=0.49, <i>P</i>=0.007) and glucose (r=0.39, <i>P</i>=0.038) in diabetic women. In OW/OB non-diabetic subjects, resistin correlated with insulin (r=0.59, <i>P</i>=0.015) and HOMA-R (r=0.616, <i>P</i>=0.011). No correlation was observed with glucose, height, hip, waist, weight, and waist-hip ratio (WHR) in the lean and OW/OB non-diabetic groups. <b>CONCLUSION</b> : Resistin concentrations are elevated in patients with type 2 diabetes and are associated with obesity and insulin resistance. These data indicate that resistin might be involved in the development of diabetes in humans. |
| first_indexed | 2024-12-23T13:04:16Z |
| format | Article |
| id | doaj.art-6e69b86706b14fe9978c3489dc48c841 |
| institution | Directory Open Access Journal |
| issn | 0256-4947 0975-4466 |
| language | English |
| last_indexed | 2024-12-23T13:04:16Z |
| publishDate | 2005-01-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj.art-6e69b86706b14fe9978c3489dc48c8412022-12-21T17:45:57ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662005-01-01254283287Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus.Al-Harithy RowydaAl-Ghamdi Shareefa<b>BACKGROUND</b> : The role of adipocyte hormones in modulating insulin sensitivity and glucose tolerance are of increasing interest and importance in studies of type 2 diabetes mellitus. Recently a unique signaling molecule, resistin, has been proposed as playing a role in the pathogenesis of obesity-related insulin resistance, but its relevance to human diabetes remains uncertain. Therefore, we assessed the relationship between serum resistin concentrations and insulin resistance in lean, overweight and obese (OW/OB) non-diabetic and diabetic Saudi women. <b>SUBJECTS AND METHODS</b> : We measured fasting serum resistin levels in 44 diabetic women with a mean body mass index (BMI) of 31.82±4.35 kg/m2, 21 OW/OB non-diabetic women with a mean BMI 30.71±3.42 kg/m2 and in 24 lean women with a mean BMI of 23.33±1.24 kg/m2. Insulin resistance was assessed using the homeostasis model assessment for insulin resistance formula derived from fasting insulin and glucose levels. <b>RESULTS</b> : The concentrations of fasting serum resistin showed significant differences among the three groups (<i>P</i>< 0.001). Mean serum resistin concentrations increased from lean (11.59± 2.08) to OW/OB non-diabetic (16.29±2.29) to diabetic (19.42±3.60 ng/mL) women. Significantly higher levels of glucose (<i>P</i>< 0.001) and values for the homeostasis model assessment ratio (HOMA-R) (<i>P</i>< 0.01) occurred in the diabetic compared to the lean and OW/OB non-diabetic subjects. Furthermore, resistin correlated significantly and positively with hip circumferences (r=0.39, <i>P</i>=0.039), weight (r=0.51, <i>P</i>=0.005), insulin (r=0.40, <i>P</i>=0.033), HOMA-R (r=0.49, <i>P</i>=0.007) and glucose (r=0.39, <i>P</i>=0.038) in diabetic women. In OW/OB non-diabetic subjects, resistin correlated with insulin (r=0.59, <i>P</i>=0.015) and HOMA-R (r=0.616, <i>P</i>=0.011). No correlation was observed with glucose, height, hip, waist, weight, and waist-hip ratio (WHR) in the lean and OW/OB non-diabetic groups. <b>CONCLUSION</b> : Resistin concentrations are elevated in patients with type 2 diabetes and are associated with obesity and insulin resistance. These data indicate that resistin might be involved in the development of diabetes in humans.http://www.saudiannals.net/article.asp?issn=0256-4947;year=2005;volume=25;issue=4;spage=283;epage=287;aulast=Al-Harithy |
| spellingShingle | Al-Harithy Rowyda Al-Ghamdi Shareefa Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus. Annals of Saudi Medicine |
| title | Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus. |
| title_full | Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus. |
| title_fullStr | Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus. |
| title_full_unstemmed | Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus. |
| title_short | Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus. |
| title_sort | serum resistin adiposity and insulin resistance in saudi women with type 2 diabetes mellitus |
| url | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2005;volume=25;issue=4;spage=283;epage=287;aulast=Al-Harithy |
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