Extra-virgin olive oil and its phenolic extract prevent inflammatory response and joint damage in murine experimental arthritis
The consumption of EVOO in Mediterranean countries has shown beneficial effects. A wide range of evidence indicates that the phenolic compounds present in EVOO are endowed with anti-inflammatory properties. In this work, we evaluated the effects of dietary EVOO and treatment with its phenolic extrac...
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| Format: | Article |
| Language: | English |
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Consejo Superior de Investigaciones Científicas
2016-12-01
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| Series: | Grasas y Aceites |
| Subjects: | |
| Online Access: | http://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1623 |
| _version_ | 1819053754603798528 |
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| author | M. A. Rosillo M. Sánchez-Hidalgo C. Alarcón-de-la-Lastra |
| author_facet | M. A. Rosillo M. Sánchez-Hidalgo C. Alarcón-de-la-Lastra |
| author_sort | M. A. Rosillo |
| collection | DOAJ |
| description | The consumption of EVOO in Mediterranean countries has shown beneficial effects. A wide range of evidence indicates that the phenolic compounds present in EVOO are endowed with anti-inflammatory properties. In this work, we evaluated the effects of dietary EVOO and treatment with its phenolic extract (PE) in a model of RA, the collagen-induced arthritis (CIA) in mice. On day 0, DBA-1/J mice were immunized with bovine collagen type II (CII). On day 21, the mice received a booster injection. We have demonstrated that EVOO and its PE decreases joint edema, cell migration, cartilage degradation and bone erosion. Our data indicate that dietary EVOO and PE treatment inhibit JNK, p38 and signal transducer and STAT-3. In addition, both EVOO and PE decrease NF-κB translocation leading to the down-regulation of the arthritic process. These results support the interest of natural diet components in the development of therapeutic products for arthritic conditions. |
| first_indexed | 2024-12-21T12:40:45Z |
| format | Article |
| id | doaj.art-6e69d7e5188e4ccf82485b674b168353 |
| institution | Directory Open Access Journal |
| issn | 0017-3495 1988-4214 |
| language | English |
| last_indexed | 2024-12-21T12:40:45Z |
| publishDate | 2016-12-01 |
| publisher | Consejo Superior de Investigaciones Científicas |
| record_format | Article |
| series | Grasas y Aceites |
| spelling | doaj.art-6e69d7e5188e4ccf82485b674b1683532022-12-21T19:03:47ZengConsejo Superior de Investigaciones CientíficasGrasas y Aceites0017-34951988-42142016-12-01674e158e15810.3989/gya.04491611590Extra-virgin olive oil and its phenolic extract prevent inflammatory response and joint damage in murine experimental arthritisM. A. Rosillo0M. Sánchez-Hidalgo1C. Alarcón-de-la-Lastra2Department of Pharmacology, Faculty of Pharmacy, University of SevilleDepartment of Pharmacology, Faculty of Pharmacy, University of SevilleDepartment of Pharmacology, Faculty of Pharmacy, University of SevilleThe consumption of EVOO in Mediterranean countries has shown beneficial effects. A wide range of evidence indicates that the phenolic compounds present in EVOO are endowed with anti-inflammatory properties. In this work, we evaluated the effects of dietary EVOO and treatment with its phenolic extract (PE) in a model of RA, the collagen-induced arthritis (CIA) in mice. On day 0, DBA-1/J mice were immunized with bovine collagen type II (CII). On day 21, the mice received a booster injection. We have demonstrated that EVOO and its PE decreases joint edema, cell migration, cartilage degradation and bone erosion. Our data indicate that dietary EVOO and PE treatment inhibit JNK, p38 and signal transducer and STAT-3. In addition, both EVOO and PE decrease NF-κB translocation leading to the down-regulation of the arthritic process. These results support the interest of natural diet components in the development of therapeutic products for arthritic conditions.http://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1623ciaevooinflammatory responseolive oilpolyphenolsrheumatoid arthritis |
| spellingShingle | M. A. Rosillo M. Sánchez-Hidalgo C. Alarcón-de-la-Lastra Extra-virgin olive oil and its phenolic extract prevent inflammatory response and joint damage in murine experimental arthritis Grasas y Aceites cia evoo inflammatory response olive oil polyphenols rheumatoid arthritis |
| title | Extra-virgin olive oil and its phenolic extract prevent inflammatory response and joint damage in murine experimental arthritis |
| title_full | Extra-virgin olive oil and its phenolic extract prevent inflammatory response and joint damage in murine experimental arthritis |
| title_fullStr | Extra-virgin olive oil and its phenolic extract prevent inflammatory response and joint damage in murine experimental arthritis |
| title_full_unstemmed | Extra-virgin olive oil and its phenolic extract prevent inflammatory response and joint damage in murine experimental arthritis |
| title_short | Extra-virgin olive oil and its phenolic extract prevent inflammatory response and joint damage in murine experimental arthritis |
| title_sort | extra virgin olive oil and its phenolic extract prevent inflammatory response and joint damage in murine experimental arthritis |
| topic | cia evoo inflammatory response olive oil polyphenols rheumatoid arthritis |
| url | http://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1623 |
| work_keys_str_mv | AT marosillo extravirginoliveoilanditsphenolicextractpreventinflammatoryresponseandjointdamageinmurineexperimentalarthritis AT msanchezhidalgo extravirginoliveoilanditsphenolicextractpreventinflammatoryresponseandjointdamageinmurineexperimentalarthritis AT calarcondelalastra extravirginoliveoilanditsphenolicextractpreventinflammatoryresponseandjointdamageinmurineexperimentalarthritis |