Potential Role of Hydroxyapatite Nanocrystalline for Early Diagnostics of Ovarian Cancer
Calcification is one of the clinical and morphological manifestations of ovarian tumors and it begins at the initial stages of carcinogenesis. Thus, this process can be used for the early diagnostics of some malignant ovarian tumors. We compared the results of ultrasound and histology and found that...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/10/1741 |
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| author | Ruslana Chyzhma Artem Piddubnyi Sergey Danilchenko Olha Kravtsova Roman Moskalenko |
| author_facet | Ruslana Chyzhma Artem Piddubnyi Sergey Danilchenko Olha Kravtsova Roman Moskalenko |
| author_sort | Ruslana Chyzhma |
| collection | DOAJ |
| description | Calcification is one of the clinical and morphological manifestations of ovarian tumors and it begins at the initial stages of carcinogenesis. Thus, this process can be used for the early diagnostics of some malignant ovarian tumors. We compared the results of ultrasound and histology and found that calcifications of a size less than 200 μm are not detected by ultrasound. These calcified structures are round fragile particles of different sizes. In the EDX (Energy-dispersive X-ray spectroscopy) spectra, the main lines were from Ca and P, and the ratio of these elements corresponds to hydroxyapatite. Thus, we established that hydroxyapatite is the main mineral component of ovarian psammoma bodies and could be used for early diagnostics of ovarian malignant neoplasia. |
| first_indexed | 2024-03-10T06:37:33Z |
| format | Article |
| id | doaj.art-6e6a74277cc74fc9981e47635306d380 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T06:37:33Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6e6a74277cc74fc9981e47635306d3802023-11-22T17:56:01ZengMDPI AGDiagnostics2075-44182021-09-011110174110.3390/diagnostics11101741Potential Role of Hydroxyapatite Nanocrystalline for Early Diagnostics of Ovarian CancerRuslana Chyzhma0Artem Piddubnyi1Sergey Danilchenko2Olha Kravtsova3Roman Moskalenko4Department of Pathology, Sumy State University, 40007 Sumy, UkraineDepartment of Pathology, Sumy State University, 40007 Sumy, UkraineInstitute of Applied Physics NAS of Ukraine, 40007 Sumy, UkraineDepartment of Pathology, Sumy State University, 40007 Sumy, UkraineDepartment of Pathology, Sumy State University, 40007 Sumy, UkraineCalcification is one of the clinical and morphological manifestations of ovarian tumors and it begins at the initial stages of carcinogenesis. Thus, this process can be used for the early diagnostics of some malignant ovarian tumors. We compared the results of ultrasound and histology and found that calcifications of a size less than 200 μm are not detected by ultrasound. These calcified structures are round fragile particles of different sizes. In the EDX (Energy-dispersive X-ray spectroscopy) spectra, the main lines were from Ca and P, and the ratio of these elements corresponds to hydroxyapatite. Thus, we established that hydroxyapatite is the main mineral component of ovarian psammoma bodies and could be used for early diagnostics of ovarian malignant neoplasia.https://www.mdpi.com/2075-4418/11/10/1741hydroxyapatitecalcificationovarian cancerearly diagnostics |
| spellingShingle | Ruslana Chyzhma Artem Piddubnyi Sergey Danilchenko Olha Kravtsova Roman Moskalenko Potential Role of Hydroxyapatite Nanocrystalline for Early Diagnostics of Ovarian Cancer Diagnostics hydroxyapatite calcification ovarian cancer early diagnostics |
| title | Potential Role of Hydroxyapatite Nanocrystalline for Early Diagnostics of Ovarian Cancer |
| title_full | Potential Role of Hydroxyapatite Nanocrystalline for Early Diagnostics of Ovarian Cancer |
| title_fullStr | Potential Role of Hydroxyapatite Nanocrystalline for Early Diagnostics of Ovarian Cancer |
| title_full_unstemmed | Potential Role of Hydroxyapatite Nanocrystalline for Early Diagnostics of Ovarian Cancer |
| title_short | Potential Role of Hydroxyapatite Nanocrystalline for Early Diagnostics of Ovarian Cancer |
| title_sort | potential role of hydroxyapatite nanocrystalline for early diagnostics of ovarian cancer |
| topic | hydroxyapatite calcification ovarian cancer early diagnostics |
| url | https://www.mdpi.com/2075-4418/11/10/1741 |
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