Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study
Although gut microbiome dysbiosis has been illustrated in celiac disease (CD), there are disagreements about what constitutes these microbial signatures and the timeline by which they precede diagnosis is largely unknown. The study of high-genetic-risk patients or those already with CD limits our kn...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.920735/full |
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| author | Patricia L. Milletich Angelica P. Ahrens Jordan T. Russell Joseph R. Petrone Meghan A. Berryman Daniel Agardh Jonas F. Ludvigsson Jonas F. Ludvigsson Eric W. Triplett Johnny Ludvigsson |
| author_facet | Patricia L. Milletich Angelica P. Ahrens Jordan T. Russell Joseph R. Petrone Meghan A. Berryman Daniel Agardh Jonas F. Ludvigsson Jonas F. Ludvigsson Eric W. Triplett Johnny Ludvigsson |
| author_sort | Patricia L. Milletich |
| collection | DOAJ |
| description | Although gut microbiome dysbiosis has been illustrated in celiac disease (CD), there are disagreements about what constitutes these microbial signatures and the timeline by which they precede diagnosis is largely unknown. The study of high-genetic-risk patients or those already with CD limits our knowledge of dysbiosis that may occur early in life in a generalized population. To explore early gut microbial imbalances correlated with future celiac disease (fCD), we analyzed the stool of 1478 infants aged one year, 26 of whom later acquired CD, with a mean age of diagnosis of 10.96 ± 5.6 years. With a novel iterative control-matching algorithm using the prospective general population cohort, All Babies In Southeast Sweden, we found nine core microbes with prevalence differences and seven differentially abundant bacteria between fCD infants and controls. The differences were validated using 100 separate, iterative permutations of matched controls, which suggests the bacterial signatures are significant in fCD even when accounting for the inherent variability in a general population. This work is the first to our knowledge to demonstrate that gut microbial differences in prevalence and abundance exist in infants aged one year up to 19 years before a diagnosis of CD in a general population. |
| first_indexed | 2024-04-14T03:52:27Z |
| format | Article |
| id | doaj.art-6e6b6125c97248ce85a85399ed1c14a4 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-14T03:52:27Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-6e6b6125c97248ce85a85399ed1c14a42022-12-22T02:13:57ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-07-011210.3389/fcimb.2022.920735920735Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS studyPatricia L. Milletich0Angelica P. Ahrens1Jordan T. Russell2Joseph R. Petrone3Meghan A. Berryman4Daniel Agardh5Jonas F. Ludvigsson6Jonas F. Ludvigsson7Eric W. Triplett8Johnny Ludvigsson9Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, United StatesDepartment of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, United StatesDepartment of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, United StatesDepartment of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, United StatesDepartment of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, United StatesDepartment of Clinical Sciences, Lund University, Malmö, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, SwedenDepartment of Pediatrics, Örebro University Hospital, Örebro, SwedenDepartment of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, United StatesCrown Princess Victoria’s Children’s Hospital and Division of Pediatrics, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SwedenAlthough gut microbiome dysbiosis has been illustrated in celiac disease (CD), there are disagreements about what constitutes these microbial signatures and the timeline by which they precede diagnosis is largely unknown. The study of high-genetic-risk patients or those already with CD limits our knowledge of dysbiosis that may occur early in life in a generalized population. To explore early gut microbial imbalances correlated with future celiac disease (fCD), we analyzed the stool of 1478 infants aged one year, 26 of whom later acquired CD, with a mean age of diagnosis of 10.96 ± 5.6 years. With a novel iterative control-matching algorithm using the prospective general population cohort, All Babies In Southeast Sweden, we found nine core microbes with prevalence differences and seven differentially abundant bacteria between fCD infants and controls. The differences were validated using 100 separate, iterative permutations of matched controls, which suggests the bacterial signatures are significant in fCD even when accounting for the inherent variability in a general population. This work is the first to our knowledge to demonstrate that gut microbial differences in prevalence and abundance exist in infants aged one year up to 19 years before a diagnosis of CD in a general population.https://www.frontiersin.org/articles/10.3389/fcimb.2022.920735/fullceliac diseaseautoimmunityhuman leucocyte antigeninfantgut microbiome |
| spellingShingle | Patricia L. Milletich Angelica P. Ahrens Jordan T. Russell Joseph R. Petrone Meghan A. Berryman Daniel Agardh Jonas F. Ludvigsson Jonas F. Ludvigsson Eric W. Triplett Johnny Ludvigsson Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study Frontiers in Cellular and Infection Microbiology celiac disease autoimmunity human leucocyte antigen infant gut microbiome |
| title | Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study |
| title_full | Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study |
| title_fullStr | Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study |
| title_full_unstemmed | Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study |
| title_short | Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study |
| title_sort | gut microbiome markers in subgroups of hla class ii genotyped infants signal future celiac disease in the general population abis study |
| topic | celiac disease autoimmunity human leucocyte antigen infant gut microbiome |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.920735/full |
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