Molecular mechanism of hyperactive tooth root formation in oculo-facio-cardio-dental syndrome

Molecular mechanism of hyperactive tooth root formation in oculo-facio-cardio-dental syndrome

Mutations in the B-cell lymphoma 6 (BCL6) interacting corepressor (BCOR) cause oculo-facio-cardio-dental (OFCD) syndrome, a rare X-linked dominant condition that includes dental radiculomegaly among other characteristics. BCOR regulates downstream genes via BCL6 as a transcriptional corepressor. How...

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Bibliographic Details
Main Authors: Kyaw Min Soe, Takuya Ogawa, Keiji Moriyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Physiology
Subjects:
BCL6
BCOR
OFCD syndrome
radiculomegaly
ZFPM2
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.946282/full

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