The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo
Corydalis yanhusuo W. T. Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one of the herb components of many Chinese Traditional Medicine prescriptions such as Jin Ling Zi San and Yuanhu-Zhitong priscription. C. yanhusuo was traditionally used to relieve pain and motivate blood and Qi circ...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223013094 |
| _version_ | 1797660581923127296 |
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| author | Jia-hua Feng Kang Chen Si-yu Shen Yun-feng Luo Xi-hong Liu Xin Chen Wei Gao Yu-ru Tong |
| author_facet | Jia-hua Feng Kang Chen Si-yu Shen Yun-feng Luo Xi-hong Liu Xin Chen Wei Gao Yu-ru Tong |
| author_sort | Jia-hua Feng |
| collection | DOAJ |
| description | Corydalis yanhusuo W. T. Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one of the herb components of many Chinese Traditional Medicine prescriptions such as Jin Ling Zi San and Yuanhu-Zhitong priscription. C. yanhusuo was traditionally used to relieve pain and motivate blood and Qi circulation. Now there has been growing interest in pharmacological effects of alkaloids, the main bioactive components of C. yanhusuo. Eighty-four alkaloids isolated from C. yanhusuo are its important bioactive components and can be characterized into protoberberine alkaloids, aporphine alkaloids, opiate alkaloids and others and proper extraction or co-administration methods modulate their contents and efficacy. Alkaloids from C. yanhusuo have various pharmacological effects on the nervous system, cardiovascular system, cancer and others through multiple molecular mechanisms such as modulating neurotransmitters, ion channels, gut microbiota, HPA axis and signaling pathways and are potential treatments for many diseases. Plenty of novel drug delivery methods such as autologous red blood cells, self-microemulsifying drug delivery systems, nanoparticles and others have also been investigated to better exert the effects of alkaloids from C. yanhusuo. This review summarized the alkaloid components of C. yanhusuo, their pharmacological effects and mechanisms, and methods of drug delivery to lay a foundation for future investigations. |
| first_indexed | 2024-03-11T18:31:58Z |
| format | Article |
| id | doaj.art-6e6c941ce37546ccaddee57d3f0253b6 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T18:31:58Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-6e6c941ce37546ccaddee57d3f0253b62023-10-13T11:02:53ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-11-01167115511The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuoJia-hua Feng0Kang Chen1Si-yu Shen2Yun-feng Luo3Xi-hong Liu4Xin Chen5Wei Gao6Yu-ru Tong7School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, ChinaNational Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaSchool of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, ChinaSchool of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, ChinaSchool of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaSchool of Basic Medical Sciences, Capital Medical University, Beijing 100069, ChinaSchool of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, ChinaSchool of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China; Corresponding author.Corydalis yanhusuo W. T. Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one of the herb components of many Chinese Traditional Medicine prescriptions such as Jin Ling Zi San and Yuanhu-Zhitong priscription. C. yanhusuo was traditionally used to relieve pain and motivate blood and Qi circulation. Now there has been growing interest in pharmacological effects of alkaloids, the main bioactive components of C. yanhusuo. Eighty-four alkaloids isolated from C. yanhusuo are its important bioactive components and can be characterized into protoberberine alkaloids, aporphine alkaloids, opiate alkaloids and others and proper extraction or co-administration methods modulate their contents and efficacy. Alkaloids from C. yanhusuo have various pharmacological effects on the nervous system, cardiovascular system, cancer and others through multiple molecular mechanisms such as modulating neurotransmitters, ion channels, gut microbiota, HPA axis and signaling pathways and are potential treatments for many diseases. Plenty of novel drug delivery methods such as autologous red blood cells, self-microemulsifying drug delivery systems, nanoparticles and others have also been investigated to better exert the effects of alkaloids from C. yanhusuo. This review summarized the alkaloid components of C. yanhusuo, their pharmacological effects and mechanisms, and methods of drug delivery to lay a foundation for future investigations.http://www.sciencedirect.com/science/article/pii/S0753332223013094Corydalis yanhusuoPapaveraceaeAlkaloidsPharmacological effectsTraditional Chinese medicine |
| spellingShingle | Jia-hua Feng Kang Chen Si-yu Shen Yun-feng Luo Xi-hong Liu Xin Chen Wei Gao Yu-ru Tong The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo Biomedicine & Pharmacotherapy Corydalis yanhusuo Papaveraceae Alkaloids Pharmacological effects Traditional Chinese medicine |
| title | The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo |
| title_full | The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo |
| title_fullStr | The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo |
| title_full_unstemmed | The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo |
| title_short | The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo |
| title_sort | composition pharmacological effects related mechanisms and drug delivery of alkaloids from corydalis yanhusuo |
| topic | Corydalis yanhusuo Papaveraceae Alkaloids Pharmacological effects Traditional Chinese medicine |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223013094 |
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