Metabolomics in drug research and development: The recent advances in technologies and applications
Emerging evidence has demonstrated the vital role of metabolism in various diseases or disorders. Metabolomics provides a comprehensive understanding of metabolism in biological systems. With advanced analytical techniques, metabolomics exhibits unprecedented significant value in basic drug research...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383523001661 |
| _version_ | 1797740853672804352 |
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| author | Huanhuan Pang Zeping Hu |
| author_facet | Huanhuan Pang Zeping Hu |
| author_sort | Huanhuan Pang |
| collection | DOAJ |
| description | Emerging evidence has demonstrated the vital role of metabolism in various diseases or disorders. Metabolomics provides a comprehensive understanding of metabolism in biological systems. With advanced analytical techniques, metabolomics exhibits unprecedented significant value in basic drug research, including understanding disease mechanisms, identifying drug targets, and elucidating the mode of action of drugs. More importantly, metabolomics greatly accelerates the drug development process by predicting pharmacokinetics, pharmacodynamics, and drug response. In addition, metabolomics facilitates the exploration of drug repurposing and drug-drug interactions, as well as the development of personalized treatment strategies. Here, we briefly review the recent advances in technologies in metabolomics and update our knowledge of the applications of metabolomics in drug research and development. |
| first_indexed | 2024-03-12T14:18:27Z |
| format | Article |
| id | doaj.art-6e7040e49e2f46088b7d1fac07814068 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-03-12T14:18:27Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-6e7040e49e2f46088b7d1fac078140682023-08-20T04:37:50ZengElsevierActa Pharmaceutica Sinica B2211-38352023-08-0113832383251Metabolomics in drug research and development: The recent advances in technologies and applicationsHuanhuan Pang0Zeping Hu1School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing 100084, ChinaCorresponding author.; School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing 100084, ChinaEmerging evidence has demonstrated the vital role of metabolism in various diseases or disorders. Metabolomics provides a comprehensive understanding of metabolism in biological systems. With advanced analytical techniques, metabolomics exhibits unprecedented significant value in basic drug research, including understanding disease mechanisms, identifying drug targets, and elucidating the mode of action of drugs. More importantly, metabolomics greatly accelerates the drug development process by predicting pharmacokinetics, pharmacodynamics, and drug response. In addition, metabolomics facilitates the exploration of drug repurposing and drug-drug interactions, as well as the development of personalized treatment strategies. Here, we briefly review the recent advances in technologies in metabolomics and update our knowledge of the applications of metabolomics in drug research and development.http://www.sciencedirect.com/science/article/pii/S2211383523001661MetabolomicsTechnologyDrug research and developmentDrug targetMode of action of drugDrug response |
| spellingShingle | Huanhuan Pang Zeping Hu Metabolomics in drug research and development: The recent advances in technologies and applications Acta Pharmaceutica Sinica B Metabolomics Technology Drug research and development Drug target Mode of action of drug Drug response |
| title | Metabolomics in drug research and development: The recent advances in technologies and applications |
| title_full | Metabolomics in drug research and development: The recent advances in technologies and applications |
| title_fullStr | Metabolomics in drug research and development: The recent advances in technologies and applications |
| title_full_unstemmed | Metabolomics in drug research and development: The recent advances in technologies and applications |
| title_short | Metabolomics in drug research and development: The recent advances in technologies and applications |
| title_sort | metabolomics in drug research and development the recent advances in technologies and applications |
| topic | Metabolomics Technology Drug research and development Drug target Mode of action of drug Drug response |
| url | http://www.sciencedirect.com/science/article/pii/S2211383523001661 |
| work_keys_str_mv | AT huanhuanpang metabolomicsindrugresearchanddevelopmenttherecentadvancesintechnologiesandapplications AT zepinghu metabolomicsindrugresearchanddevelopmenttherecentadvancesintechnologiesandapplications |