Analysis of gene expression in intracranial aneurysms
Abstract Background Different gene expression profiles are observed in intracranial aneurysm tissue. Understanding these genes and what regulates their expression will help us to understand intracranial aneurysm pathogenesis. We investigated whether differences in gene expression in intracranial ane...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-10-01
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| Series: | Chinese Neurosurgical Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41016-017-0098-z |
| _version_ | 1819047557856231424 |
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| author | Jia Wang Lanbing Yu Dong Zhang Shuo Wang Jizong Zhao |
| author_facet | Jia Wang Lanbing Yu Dong Zhang Shuo Wang Jizong Zhao |
| author_sort | Jia Wang |
| collection | DOAJ |
| description | Abstract Background Different gene expression profiles are observed in intracranial aneurysm tissue. Understanding these genes and what regulates their expression will help us to understand intracranial aneurysm pathogenesis. We investigated whether differences in gene expression in intracranial aneurysms. Methods Sixteen intracranial aneurysm tissues were compared with 16 matched samples from the superficial temporal artery as controls. We detected the gene expression profiles in these samples with the Human U133 Plus 2.0 GeneChip. Results A total of 2142 differentially expressed gene transcripts were detected based on the gene expression profile. Verification analysis showed that the VCAM1, MAGI2, PPP2R2B, PPP2R3A genes were associated with the occurrence and development of intracranial aneurysm. These genes mainly encode cell adhesion molecules (CAMs) and ERK/JNK signaling pathways. Conclusion Changes of genes expression involved in immune and inflammatory reactions, cell adhesion molecules may be associated with the development of aneurysms. |
| first_indexed | 2024-12-21T11:02:16Z |
| format | Article |
| id | doaj.art-6e70816809ef4a958567bf7f04c768bf |
| institution | Directory Open Access Journal |
| issn | 2057-4967 |
| language | English |
| last_indexed | 2024-12-21T11:02:16Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Neurosurgical Journal |
| spelling | doaj.art-6e70816809ef4a958567bf7f04c768bf2022-12-21T19:06:19ZengBMCChinese Neurosurgical Journal2057-49672017-10-01311510.1186/s41016-017-0098-zAnalysis of gene expression in intracranial aneurysmsJia Wang0Lanbing Yu1Dong Zhang2Shuo Wang3Jizong Zhao4Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background Different gene expression profiles are observed in intracranial aneurysm tissue. Understanding these genes and what regulates their expression will help us to understand intracranial aneurysm pathogenesis. We investigated whether differences in gene expression in intracranial aneurysms. Methods Sixteen intracranial aneurysm tissues were compared with 16 matched samples from the superficial temporal artery as controls. We detected the gene expression profiles in these samples with the Human U133 Plus 2.0 GeneChip. Results A total of 2142 differentially expressed gene transcripts were detected based on the gene expression profile. Verification analysis showed that the VCAM1, MAGI2, PPP2R2B, PPP2R3A genes were associated with the occurrence and development of intracranial aneurysm. These genes mainly encode cell adhesion molecules (CAMs) and ERK/JNK signaling pathways. Conclusion Changes of genes expression involved in immune and inflammatory reactions, cell adhesion molecules may be associated with the development of aneurysms.http://link.springer.com/article/10.1186/s41016-017-0098-zIntracranial aneurysmGene expression profileMicroarray analysis |
| spellingShingle | Jia Wang Lanbing Yu Dong Zhang Shuo Wang Jizong Zhao Analysis of gene expression in intracranial aneurysms Chinese Neurosurgical Journal Intracranial aneurysm Gene expression profile Microarray analysis |
| title | Analysis of gene expression in intracranial aneurysms |
| title_full | Analysis of gene expression in intracranial aneurysms |
| title_fullStr | Analysis of gene expression in intracranial aneurysms |
| title_full_unstemmed | Analysis of gene expression in intracranial aneurysms |
| title_short | Analysis of gene expression in intracranial aneurysms |
| title_sort | analysis of gene expression in intracranial aneurysms |
| topic | Intracranial aneurysm Gene expression profile Microarray analysis |
| url | http://link.springer.com/article/10.1186/s41016-017-0098-z |
| work_keys_str_mv | AT jiawang analysisofgeneexpressioninintracranialaneurysms AT lanbingyu analysisofgeneexpressioninintracranialaneurysms AT dongzhang analysisofgeneexpressioninintracranialaneurysms AT shuowang analysisofgeneexpressioninintracranialaneurysms AT jizongzhao analysisofgeneexpressioninintracranialaneurysms |