Could SARS-CoV-1 Vaccines in the Pipeline Have Contributed to Fighting the COVID-19 Pandemic? Lessons for the Next Coronavirus Plague
SARS-CoV-2 caused the devastating COVID-19 pandemic, which, to date, has resulted in more than 800 million confirmed cases and 7 million deaths worldwide. The rapid development and distribution (at least in high-income countries) of various vaccines prevented these overwhelming numbers of infections...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/1/62 |
| _version_ | 1797340083757514752 |
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| author | Daniel López Marina García-Peydró |
| author_facet | Daniel López Marina García-Peydró |
| author_sort | Daniel López |
| collection | DOAJ |
| description | SARS-CoV-2 caused the devastating COVID-19 pandemic, which, to date, has resulted in more than 800 million confirmed cases and 7 million deaths worldwide. The rapid development and distribution (at least in high-income countries) of various vaccines prevented these overwhelming numbers of infections and deaths from being much higher. But would it have been possible to develop a prophylaxis against this pandemic more quickly? Since SARS-CoV-2 belongs to the subgenus sarbecovirus, with its highly homologous SARS-CoV-1, we propose here that while SARS-CoV-2-specific vaccines are being developed, phase II clinical trials of specific SARS-CoV-1 vaccines, which have been in the pipeline since the early 20th century, could have been conducted to test a highly probable cross-protection between SARS-CoV-1 and SARS-CoV-2. |
| first_indexed | 2024-03-08T09:57:50Z |
| format | Article |
| id | doaj.art-6e71d7551e004f94952481abb145aef0 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T09:57:50Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-6e71d7551e004f94952481abb145aef02024-01-29T13:46:50ZengMDPI AGBiomedicines2227-90592023-12-011216210.3390/biomedicines12010062Could SARS-CoV-1 Vaccines in the Pipeline Have Contributed to Fighting the COVID-19 Pandemic? Lessons for the Next Coronavirus PlagueDaniel López0Marina García-Peydró1Presentation and Immune Regulation Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, SpainCentro de Biología Molecular Severo Ochoa, CSIC-UAM, 28049 Madrid, SpainSARS-CoV-2 caused the devastating COVID-19 pandemic, which, to date, has resulted in more than 800 million confirmed cases and 7 million deaths worldwide. The rapid development and distribution (at least in high-income countries) of various vaccines prevented these overwhelming numbers of infections and deaths from being much higher. But would it have been possible to develop a prophylaxis against this pandemic more quickly? Since SARS-CoV-2 belongs to the subgenus sarbecovirus, with its highly homologous SARS-CoV-1, we propose here that while SARS-CoV-2-specific vaccines are being developed, phase II clinical trials of specific SARS-CoV-1 vaccines, which have been in the pipeline since the early 20th century, could have been conducted to test a highly probable cross-protection between SARS-CoV-1 and SARS-CoV-2.https://www.mdpi.com/2227-9059/12/1/62HLAvaccinescross-reactivityT cellsSARS-CoV-2 |
| spellingShingle | Daniel López Marina García-Peydró Could SARS-CoV-1 Vaccines in the Pipeline Have Contributed to Fighting the COVID-19 Pandemic? Lessons for the Next Coronavirus Plague Biomedicines HLA vaccines cross-reactivity T cells SARS-CoV-2 |
| title | Could SARS-CoV-1 Vaccines in the Pipeline Have Contributed to Fighting the COVID-19 Pandemic? Lessons for the Next Coronavirus Plague |
| title_full | Could SARS-CoV-1 Vaccines in the Pipeline Have Contributed to Fighting the COVID-19 Pandemic? Lessons for the Next Coronavirus Plague |
| title_fullStr | Could SARS-CoV-1 Vaccines in the Pipeline Have Contributed to Fighting the COVID-19 Pandemic? Lessons for the Next Coronavirus Plague |
| title_full_unstemmed | Could SARS-CoV-1 Vaccines in the Pipeline Have Contributed to Fighting the COVID-19 Pandemic? Lessons for the Next Coronavirus Plague |
| title_short | Could SARS-CoV-1 Vaccines in the Pipeline Have Contributed to Fighting the COVID-19 Pandemic? Lessons for the Next Coronavirus Plague |
| title_sort | could sars cov 1 vaccines in the pipeline have contributed to fighting the covid 19 pandemic lessons for the next coronavirus plague |
| topic | HLA vaccines cross-reactivity T cells SARS-CoV-2 |
| url | https://www.mdpi.com/2227-9059/12/1/62 |
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