<i>Arctium lappa</i> Extract Suppresses Inflammation and Inhibits Melanoma Progression
<b>Background:</b> Arctium lappa has been used as popular medicinal herb and health supplement in Chinese societies. Bioactive components from <i>A. lappa</i> have attracted the attention of researchers due to their promising therapeutic effects. In this study, we investigate...
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| Format: | Article |
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MDPI AG
2019-07-01
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| Series: | Medicines |
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| Online Access: | https://www.mdpi.com/2305-6320/6/3/81 |
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| author | Bruno A. C. Nascimento Luiz G. Gardinassi Inaê M. G. Silveira Marília G. Gallucci Mariana A. Tomé Júlia Fernanda D. Oliveira Mirella R. A. Moreira Alyne F. G. Meirelles Lúcia H. Faccioli Cristiane Tefé-Silva Karina F. Zoccal |
| author_facet | Bruno A. C. Nascimento Luiz G. Gardinassi Inaê M. G. Silveira Marília G. Gallucci Mariana A. Tomé Júlia Fernanda D. Oliveira Mirella R. A. Moreira Alyne F. G. Meirelles Lúcia H. Faccioli Cristiane Tefé-Silva Karina F. Zoccal |
| author_sort | Bruno A. C. Nascimento |
| collection | DOAJ |
| description | <b>Background:</b> Arctium lappa has been used as popular medicinal herb and health supplement in Chinese societies. Bioactive components from <i>A. lappa</i> have attracted the attention of researchers due to their promising therapeutic effects. In this study, we investigated the effects of <i>A. lappa</i> hydroalcoholic extract (Alhe) during different models of inflammation, in vivo. <b>Methods:</b> The anti-inflammatory activity was evaluated through the air pouch model. For this, mice received an inflammatory stimulus with lipopolysaccharide (LPS) and were later injected with Alhe. To assess anti-tumoral activity, the animals were inoculated with B16F10 cells and injected with Alhe every 5 days, along the course of 30 days. Controls were submitted to the same conditions and injected with the vehicle. Peritoneal or air pouch fluids were collected to evaluate leukocyte counting or cellular activation via quantification of cytokines and nitric oxide. <b>Results:</b> Alhe injection reduced the neutrophil influx and production of inflammatory mediators in inflammatory foci after LPS or tumor challenges. Furthermore, Alhe injection reduced tumor growth and enhanced mice survival. <b>Conclusions:</b> Collectively, these data suggest that Alhe regulates immune cell migration and activation, which correlates with favorable outcome in mouse models of acute inflammation and melanoma progression. |
| first_indexed | 2024-12-23T05:17:29Z |
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| institution | Directory Open Access Journal |
| issn | 2305-6320 |
| language | English |
| last_indexed | 2024-12-23T05:17:29Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicines |
| spelling | doaj.art-6e723a224b244d8b917a12ff80c0552c2022-12-21T17:58:47ZengMDPI AGMedicines2305-63202019-07-01638110.3390/medicines6030081medicines6030081<i>Arctium lappa</i> Extract Suppresses Inflammation and Inhibits Melanoma ProgressionBruno A. C. Nascimento0Luiz G. Gardinassi1Inaê M. G. Silveira2Marília G. Gallucci3Mariana A. Tomé4Júlia Fernanda D. Oliveira5Mirella R. A. Moreira6Alyne F. G. Meirelles7Lúcia H. Faccioli8Cristiane Tefé-Silva9Karina F. Zoccal10Centro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, 14090-180 Ribeirão Preto, SP, BrazilDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (FCFRP-USP), Avenida do Café, s/n, 14040-903 Ribeirão Preto, São Paulo, BrazilCentro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, 14090-180 Ribeirão Preto, SP, BrazilCentro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, 14090-180 Ribeirão Preto, SP, BrazilCentro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, 14090-180 Ribeirão Preto, SP, BrazilCentro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, 14090-180 Ribeirão Preto, SP, BrazilDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (FCFRP-USP), Avenida do Café, s/n, 14040-903 Ribeirão Preto, São Paulo, BrazilDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (FCFRP-USP), Avenida do Café, s/n, 14040-903 Ribeirão Preto, São Paulo, BrazilDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (FCFRP-USP), Avenida do Café, s/n, 14040-903 Ribeirão Preto, São Paulo, BrazilCentro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, 14090-180 Ribeirão Preto, SP, BrazilCentro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, 14090-180 Ribeirão Preto, SP, Brazil<b>Background:</b> Arctium lappa has been used as popular medicinal herb and health supplement in Chinese societies. Bioactive components from <i>A. lappa</i> have attracted the attention of researchers due to their promising therapeutic effects. In this study, we investigated the effects of <i>A. lappa</i> hydroalcoholic extract (Alhe) during different models of inflammation, in vivo. <b>Methods:</b> The anti-inflammatory activity was evaluated through the air pouch model. For this, mice received an inflammatory stimulus with lipopolysaccharide (LPS) and were later injected with Alhe. To assess anti-tumoral activity, the animals were inoculated with B16F10 cells and injected with Alhe every 5 days, along the course of 30 days. Controls were submitted to the same conditions and injected with the vehicle. Peritoneal or air pouch fluids were collected to evaluate leukocyte counting or cellular activation via quantification of cytokines and nitric oxide. <b>Results:</b> Alhe injection reduced the neutrophil influx and production of inflammatory mediators in inflammatory foci after LPS or tumor challenges. Furthermore, Alhe injection reduced tumor growth and enhanced mice survival. <b>Conclusions:</b> Collectively, these data suggest that Alhe regulates immune cell migration and activation, which correlates with favorable outcome in mouse models of acute inflammation and melanoma progression.https://www.mdpi.com/2305-6320/6/3/81<i>Arctium lappa</i>natural productphytomedicineinflammationmelanoma |
| spellingShingle | Bruno A. C. Nascimento Luiz G. Gardinassi Inaê M. G. Silveira Marília G. Gallucci Mariana A. Tomé Júlia Fernanda D. Oliveira Mirella R. A. Moreira Alyne F. G. Meirelles Lúcia H. Faccioli Cristiane Tefé-Silva Karina F. Zoccal <i>Arctium lappa</i> Extract Suppresses Inflammation and Inhibits Melanoma Progression Medicines <i>Arctium lappa</i> natural product phytomedicine inflammation melanoma |
| title | <i>Arctium lappa</i> Extract Suppresses Inflammation and Inhibits Melanoma Progression |
| title_full | <i>Arctium lappa</i> Extract Suppresses Inflammation and Inhibits Melanoma Progression |
| title_fullStr | <i>Arctium lappa</i> Extract Suppresses Inflammation and Inhibits Melanoma Progression |
| title_full_unstemmed | <i>Arctium lappa</i> Extract Suppresses Inflammation and Inhibits Melanoma Progression |
| title_short | <i>Arctium lappa</i> Extract Suppresses Inflammation and Inhibits Melanoma Progression |
| title_sort | i arctium lappa i extract suppresses inflammation and inhibits melanoma progression |
| topic | <i>Arctium lappa</i> natural product phytomedicine inflammation melanoma |
| url | https://www.mdpi.com/2305-6320/6/3/81 |
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