Central effects of galcanezumab in migraine: a pilot study on Steady State Visual Evoked Potentials and occipital hemodynamic response in migraine patients
Abstract Background The discovery of the prominent action of Calcitonin Gene Related Peptide –CGRP- on trigeminal afferents and meningeal vessels, opened a new era in migraine treatment. However, how the block of nociceptive afferents could act on central mechanisms of migraine is still not clear. I...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-022-01421-z |
| _version_ | 1828370203498512384 |
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| author | Marina de Tommaso Marianna La Rocca Silvia Giovanna Quitadamo Katia Ricci Giusy Tancredi Livio Clemente Eleonora Gentile Elena Ammendola Marianna Delussi |
| author_facet | Marina de Tommaso Marianna La Rocca Silvia Giovanna Quitadamo Katia Ricci Giusy Tancredi Livio Clemente Eleonora Gentile Elena Ammendola Marianna Delussi |
| author_sort | Marina de Tommaso |
| collection | DOAJ |
| description | Abstract Background The discovery of the prominent action of Calcitonin Gene Related Peptide –CGRP- on trigeminal afferents and meningeal vessels, opened a new era in migraine treatment. However, how the block of nociceptive afferents could act on central mechanisms of migraine is still not clear. In this pilot study we aimed to test the effect of 3 months Galcanezumab (CGA) therapy on occipital visual reactivity in migraine patients, using the Steady State Visual Evoked Potentials-SSVEPs and Functional Near Infrared Spectroscopy –fNIRS. Method Thirteen migraine patients underwent clinical and neurophysiological examination in basal condition (T0), 1 h after GCA injection (T1) and after 3 months of GCA treatment (T2). Ten healthy volunteers were also evaluated. Results At T2, there was a reduction of headache frequency and disability. At T2, the EEG power significantly diminished as compared to T0 and T1 at occipital sites, and the topographical analysis confirmed a restoration of SSVEPs within normal values. The Oxyhemoglobin levels in occipital cortex, which were basically increased during visual stimulation in migraine patients, reverted to normal values at T2. Conclusions The present pilot study indicates that Galcanezumab could act on cortical targets located beyond the pain network, restoring the abnormal occipital reactivity. This effect could indicate the possible disease modifying properties of CGRP related monoclonal antibodies. |
| first_indexed | 2024-04-14T06:34:29Z |
| format | Article |
| id | doaj.art-6e746f6fcc3947b29853c162a6c97469 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-04-14T06:34:29Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-6e746f6fcc3947b29853c162a6c974692022-12-22T02:07:30ZengBMCThe Journal of Headache and Pain1129-23691129-23772022-04-0123111410.1186/s10194-022-01421-zCentral effects of galcanezumab in migraine: a pilot study on Steady State Visual Evoked Potentials and occipital hemodynamic response in migraine patientsMarina de Tommaso0Marianna La Rocca1Silvia Giovanna Quitadamo2Katia Ricci3Giusy Tancredi4Livio Clemente5Eleonora Gentile6Elena Ammendola7Marianna Delussi8Applied Neurophysiology and Pain Unit, Bari Aldo Moro UniversityPoliclinico General HospitalDipartimento Interateneo di Fisica ‘M. Merlin’, Università degli Studi di Bari ‘A. Moro’Applied Neurophysiology and Pain Unit, Bari Aldo Moro UniversityPoliclinico General HospitalApplied Neurophysiology and Pain Unit, Bari Aldo Moro UniversityPoliclinico General HospitalApplied Neurophysiology and Pain Unit, Bari Aldo Moro UniversityPoliclinico General HospitalApplied Neurophysiology and Pain Unit, Bari Aldo Moro UniversityPoliclinico General HospitalApplied Neurophysiology and Pain Unit, Bari Aldo Moro UniversityPoliclinico General HospitalApplied Neurophysiology and Pain Unit, Bari Aldo Moro UniversityPoliclinico General HospitalApplied Neurophysiology and Pain Unit, Bari Aldo Moro UniversityPoliclinico General HospitalAbstract Background The discovery of the prominent action of Calcitonin Gene Related Peptide –CGRP- on trigeminal afferents and meningeal vessels, opened a new era in migraine treatment. However, how the block of nociceptive afferents could act on central mechanisms of migraine is still not clear. In this pilot study we aimed to test the effect of 3 months Galcanezumab (CGA) therapy on occipital visual reactivity in migraine patients, using the Steady State Visual Evoked Potentials-SSVEPs and Functional Near Infrared Spectroscopy –fNIRS. Method Thirteen migraine patients underwent clinical and neurophysiological examination in basal condition (T0), 1 h after GCA injection (T1) and after 3 months of GCA treatment (T2). Ten healthy volunteers were also evaluated. Results At T2, there was a reduction of headache frequency and disability. At T2, the EEG power significantly diminished as compared to T0 and T1 at occipital sites, and the topographical analysis confirmed a restoration of SSVEPs within normal values. The Oxyhemoglobin levels in occipital cortex, which were basically increased during visual stimulation in migraine patients, reverted to normal values at T2. Conclusions The present pilot study indicates that Galcanezumab could act on cortical targets located beyond the pain network, restoring the abnormal occipital reactivity. This effect could indicate the possible disease modifying properties of CGRP related monoclonal antibodies.https://doi.org/10.1186/s10194-022-01421-zMigraineCGRPgalcanezumabsteady state visual evoked potentialsfNIRS |
| spellingShingle | Marina de Tommaso Marianna La Rocca Silvia Giovanna Quitadamo Katia Ricci Giusy Tancredi Livio Clemente Eleonora Gentile Elena Ammendola Marianna Delussi Central effects of galcanezumab in migraine: a pilot study on Steady State Visual Evoked Potentials and occipital hemodynamic response in migraine patients The Journal of Headache and Pain Migraine CGRP galcanezumab steady state visual evoked potentials fNIRS |
| title | Central effects of galcanezumab in migraine: a pilot study on Steady State Visual Evoked Potentials and occipital hemodynamic response in migraine patients |
| title_full | Central effects of galcanezumab in migraine: a pilot study on Steady State Visual Evoked Potentials and occipital hemodynamic response in migraine patients |
| title_fullStr | Central effects of galcanezumab in migraine: a pilot study on Steady State Visual Evoked Potentials and occipital hemodynamic response in migraine patients |
| title_full_unstemmed | Central effects of galcanezumab in migraine: a pilot study on Steady State Visual Evoked Potentials and occipital hemodynamic response in migraine patients |
| title_short | Central effects of galcanezumab in migraine: a pilot study on Steady State Visual Evoked Potentials and occipital hemodynamic response in migraine patients |
| title_sort | central effects of galcanezumab in migraine a pilot study on steady state visual evoked potentials and occipital hemodynamic response in migraine patients |
| topic | Migraine CGRP galcanezumab steady state visual evoked potentials fNIRS |
| url | https://doi.org/10.1186/s10194-022-01421-z |
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