Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence
Metabolic syndrome (MetS) refers to a cluster of metabolic dysregulations, which include insulin resistance, obesity, atherogenic dyslipidemia and hypertension. The complex pathogenesis of MetS encompasses the interplay between environmental and genetic factors. Environmental factors such as excessi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/12/3239 |
| _version_ | 1797461296288890880 |
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| author | Sok Kuan Wong Fitri Fareez Ramli Adli Ali Nurul ‘Izzah Ibrahim |
| author_facet | Sok Kuan Wong Fitri Fareez Ramli Adli Ali Nurul ‘Izzah Ibrahim |
| author_sort | Sok Kuan Wong |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) refers to a cluster of metabolic dysregulations, which include insulin resistance, obesity, atherogenic dyslipidemia and hypertension. The complex pathogenesis of MetS encompasses the interplay between environmental and genetic factors. Environmental factors such as excessive nutrients and sedentary lifestyle are modifiable and could be improved by lifestyle modification. However, genetic susceptibility to MetS, a non-modifiable factor, has attracted the attention of researchers, which could act as the basis for future diagnosis, prognosis, and therapy for MetS. Several cholesterol-related genes associated with each characteristic of MetS have been identified, such as apolipoprotein, lipoprotein lipase (LPL), cholesteryl ester transfer protein (CETP) and adiponectin. This review aims to summarize the genetic information of cholesterol-related genes in MetS, which may potentially serve as biomarkers for early prevention and management of MetS. |
| first_indexed | 2024-03-09T17:17:15Z |
| format | Article |
| id | doaj.art-6e74b03d33b241e48a3474fbd2878ecb |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:17:15Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-6e74b03d33b241e48a3474fbd2878ecb2023-11-24T13:29:15ZengMDPI AGBiomedicines2227-90592022-12-011012323910.3390/biomedicines10123239Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current EvidenceSok Kuan Wong0Fitri Fareez Ramli1Adli Ali2Nurul ‘Izzah Ibrahim3Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, MalaysiaDepartment of Pediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, MalaysiaMetabolic syndrome (MetS) refers to a cluster of metabolic dysregulations, which include insulin resistance, obesity, atherogenic dyslipidemia and hypertension. The complex pathogenesis of MetS encompasses the interplay between environmental and genetic factors. Environmental factors such as excessive nutrients and sedentary lifestyle are modifiable and could be improved by lifestyle modification. However, genetic susceptibility to MetS, a non-modifiable factor, has attracted the attention of researchers, which could act as the basis for future diagnosis, prognosis, and therapy for MetS. Several cholesterol-related genes associated with each characteristic of MetS have been identified, such as apolipoprotein, lipoprotein lipase (LPL), cholesteryl ester transfer protein (CETP) and adiponectin. This review aims to summarize the genetic information of cholesterol-related genes in MetS, which may potentially serve as biomarkers for early prevention and management of MetS.https://www.mdpi.com/2227-9059/10/12/3239cholesterol-related geneshyperlipidemiainsulin resistancehypertensionobesity |
| spellingShingle | Sok Kuan Wong Fitri Fareez Ramli Adli Ali Nurul ‘Izzah Ibrahim Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence Biomedicines cholesterol-related genes hyperlipidemia insulin resistance hypertension obesity |
| title | Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence |
| title_full | Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence |
| title_fullStr | Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence |
| title_full_unstemmed | Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence |
| title_short | Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence |
| title_sort | genetics of cholesterol related genes in metabolic syndrome a review of current evidence |
| topic | cholesterol-related genes hyperlipidemia insulin resistance hypertension obesity |
| url | https://www.mdpi.com/2227-9059/10/12/3239 |
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