3D-bioprinted GelMA nerve guidance conduits promoted peripheral nerve regeneration by inducing trans-differentiation of MSCs into SCLCs via PIEZO1/YAP axis

3D-bioprinted GelMA nerve guidance conduits promoted peripheral nerve regeneration by inducing trans-differentiation of MSCs into SCLCs via PIEZO1/YAP axis

Schwann cells (SCs)-based nerve guidance conduits (NGCs) is a promising strategy for repairing long-gap peripheral nerve injury (PNI). But the number of SCs is limited as terminally differentiated cells. Matrix stiffness is able to direct cell fate of stem cells. And nerve-special stiffness (NSS) ma...

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Bibliographic Details
Main Authors: Siyong Gao, Yuxin Tang, Wei Sun, Zhixin Liu, Tianyu Zhao, Xiang Li, Tianlu Wang, Guiqing Liao, Tao Xu, Guangsen Zheng, Yujie Liang
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Materials Today Advances
Subjects:
Peripheral nerve injury
Schwann cells
Bioprinting
Stiffness
Mechanotransduction
Online Access:http://www.sciencedirect.com/science/article/pii/S2590049822001217

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