Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastases
Merkel cell carcinoma (MCC) is a rare tumor with a high risk of recurrence after definitive therapy; however, the optimal duration of surveillance is unclear. First recurrences typically occur within 3 years. National guidelines recommend that patients undergo physical examination and imaging for su...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1217816/full |
| _version_ | 1797786706417549312 |
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| author | Joshua Rusheen James Clune Stephan Ariyan Raymond Baumann Harriet Kluger Kelly Olino Sarah Weiss |
| author_facet | Joshua Rusheen James Clune Stephan Ariyan Raymond Baumann Harriet Kluger Kelly Olino Sarah Weiss |
| author_sort | Joshua Rusheen |
| collection | DOAJ |
| description | Merkel cell carcinoma (MCC) is a rare tumor with a high risk of recurrence after definitive therapy; however, the optimal duration of surveillance is unclear. First recurrences typically occur within 3 years. National guidelines recommend that patients undergo physical examination and imaging for surveillance during this time period. However, the duration of surveillance beyond this is not defined. Here, we describe a case of a patient developing a recurrence of MCC 7 years after the primary diagnosis with interval in-transit and regional lymph node metastases 15 months following the treatment of the primary MCC. Such late recurrences are rare, largely not reported, and the risk factors contributing to late recurrences are not well described. This case highlights the possibility of late recurrences of MCC after an initial in-transit and nodal recurrence and underscores the importance of identifying predictors of recurrence that may better guide the duration of surveillance. |
| first_indexed | 2024-03-13T01:11:45Z |
| format | Article |
| id | doaj.art-6e793bb83d2a4382a3c4af3d82cc218c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T01:11:45Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-6e793bb83d2a4382a3c4af3d82cc218c2023-07-05T17:44:40ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-07-011310.3389/fonc.2023.12178161217816Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastasesJoshua Rusheen0James Clune1Stephan Ariyan2Raymond Baumann3Harriet Kluger4Kelly Olino5Sarah Weiss6Department of Medicine, Yale University School of Medicine, New Haven, CT, United StatesSection of Plastic and Reconstructive Surgery, Yale University School of Medicine, New Haven, CT, United StatesSection of Plastic and Reconstructive Surgery, Yale University School of Medicine, New Haven, CT, United StatesDatabase Management, Yale University School of Medicine, New Haven, CT, United StatesSection of Medical Oncology, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Surgery, Section of Surgical Oncology, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United StatesMerkel cell carcinoma (MCC) is a rare tumor with a high risk of recurrence after definitive therapy; however, the optimal duration of surveillance is unclear. First recurrences typically occur within 3 years. National guidelines recommend that patients undergo physical examination and imaging for surveillance during this time period. However, the duration of surveillance beyond this is not defined. Here, we describe a case of a patient developing a recurrence of MCC 7 years after the primary diagnosis with interval in-transit and regional lymph node metastases 15 months following the treatment of the primary MCC. Such late recurrences are rare, largely not reported, and the risk factors contributing to late recurrences are not well described. This case highlights the possibility of late recurrences of MCC after an initial in-transit and nodal recurrence and underscores the importance of identifying predictors of recurrence that may better guide the duration of surveillance.https://www.frontiersin.org/articles/10.3389/fonc.2023.1217816/fullMerkel cell carcinomaMerkel cellIn-transitsurveillancerecurrence |
| spellingShingle | Joshua Rusheen James Clune Stephan Ariyan Raymond Baumann Harriet Kluger Kelly Olino Sarah Weiss Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastases Frontiers in Oncology Merkel cell carcinoma Merkel cell In-transit surveillance recurrence |
| title | Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastases |
| title_full | Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastases |
| title_fullStr | Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastases |
| title_full_unstemmed | Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastases |
| title_short | Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastases |
| title_sort | case report metastatic merkel cell carcinoma presenting seven years after loco regional disease resection of primary tumor with interval in transit and nodal metastases |
| topic | Merkel cell carcinoma Merkel cell In-transit surveillance recurrence |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1217816/full |
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