The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells
Fucoidan, a sulfated polysaccharide, has a variety of biological activities, such as anti-cancer, anti-angiogenic and anti-inflammatory. However, the mechanisms of action of fucoidan as an anti-cancer agent have not been fully elucidated. The present study examined the anti-cancer effect of fucoidan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-08-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/11/8/2982 |
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| author | Hee-Kyoung Kang Jung-Mi Kwon Eun-Sook Yoo Young-Sang Koh Eun-Ji Kim Jin-Won Hyun Min-Kyoung Kim Jung-Il Kang Sang-Cheol Kim Ji-Young Hong Hye-Jin Boo |
| author_facet | Hee-Kyoung Kang Jung-Mi Kwon Eun-Sook Yoo Young-Sang Koh Eun-Ji Kim Jin-Won Hyun Min-Kyoung Kim Jung-Il Kang Sang-Cheol Kim Ji-Young Hong Hye-Jin Boo |
| author_sort | Hee-Kyoung Kang |
| collection | DOAJ |
| description | Fucoidan, a sulfated polysaccharide, has a variety of biological activities, such as anti-cancer, anti-angiogenic and anti-inflammatory. However, the mechanisms of action of fucoidan as an anti-cancer agent have not been fully elucidated. The present study examined the anti-cancer effect of fucoidan obtained from Undaria pinnatifida in PC-3 cells, human prostate cancer cells. Fucoidan induced the apoptosis of PC-3 cells by activating both intrinsic and extrinsic pathways. The induction of apoptosis was accompanied by the activation of extracellular signal-regulated kinase mitogen-activated protein kinase (ERK1/2 MAPK) and the inactivation of p38 MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt. In addition, fucoidan also induced the up-regulation of p21Cip1/Waf and down-regulation of E2F-1 cell-cycle-related proteins. Furthermore, in the Wnt/β-catenin pathway, fucoidan activated GSK-3β that resulted in the decrease of β-catenin level, followed by the decrease of c-myc and cyclin D1 expressions, target genes of β-catenin in PC-3 cells. These results suggested that fucoidan treatment could induce intrinsic and extrinsic apoptosis pathways via the activation of ERK1/2 MAPK, the inactivation of p38 MAPK and PI3K/Akt signaling pathway, and the down-regulation of Wnt/β-catenin signaling pathway in PC-3 prostate cancer cells. These data support that fucoidan might have potential for the treatment of prostate cancer. |
| first_indexed | 2024-04-11T12:11:43Z |
| format | Article |
| id | doaj.art-6e7bf00f9174482da03384ee4abf8244 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:11:43Z |
| publishDate | 2013-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-6e7bf00f9174482da03384ee4abf82442022-12-22T04:24:36ZengMDPI AGMarine Drugs1660-33972013-08-011182982299910.3390/md11082982The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer CellsHee-Kyoung KangJung-Mi KwonEun-Sook YooYoung-Sang KohEun-Ji KimJin-Won HyunMin-Kyoung KimJung-Il KangSang-Cheol KimJi-Young HongHye-Jin BooFucoidan, a sulfated polysaccharide, has a variety of biological activities, such as anti-cancer, anti-angiogenic and anti-inflammatory. However, the mechanisms of action of fucoidan as an anti-cancer agent have not been fully elucidated. The present study examined the anti-cancer effect of fucoidan obtained from Undaria pinnatifida in PC-3 cells, human prostate cancer cells. Fucoidan induced the apoptosis of PC-3 cells by activating both intrinsic and extrinsic pathways. The induction of apoptosis was accompanied by the activation of extracellular signal-regulated kinase mitogen-activated protein kinase (ERK1/2 MAPK) and the inactivation of p38 MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt. In addition, fucoidan also induced the up-regulation of p21Cip1/Waf and down-regulation of E2F-1 cell-cycle-related proteins. Furthermore, in the Wnt/β-catenin pathway, fucoidan activated GSK-3β that resulted in the decrease of β-catenin level, followed by the decrease of c-myc and cyclin D1 expressions, target genes of β-catenin in PC-3 cells. These results suggested that fucoidan treatment could induce intrinsic and extrinsic apoptosis pathways via the activation of ERK1/2 MAPK, the inactivation of p38 MAPK and PI3K/Akt signaling pathway, and the down-regulation of Wnt/β-catenin signaling pathway in PC-3 prostate cancer cells. These data support that fucoidan might have potential for the treatment of prostate cancer.http://www.mdpi.com/1660-3397/11/8/2982fucoidanPC-3 cellsapoptosisWnt/β-catenin |
| spellingShingle | Hee-Kyoung Kang Jung-Mi Kwon Eun-Sook Yoo Young-Sang Koh Eun-Ji Kim Jin-Won Hyun Min-Kyoung Kim Jung-Il Kang Sang-Cheol Kim Ji-Young Hong Hye-Jin Boo The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells Marine Drugs fucoidan PC-3 cells apoptosis Wnt/β-catenin |
| title | The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells |
| title_full | The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells |
| title_fullStr | The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells |
| title_full_unstemmed | The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells |
| title_short | The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells |
| title_sort | anticancer effect of fucoidan in pc 3 prostate cancer cells |
| topic | fucoidan PC-3 cells apoptosis Wnt/β-catenin |
| url | http://www.mdpi.com/1660-3397/11/8/2982 |
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