Mechanistic Modelling of DNA Damage Repair by the Radiation Adaptive Response Mechanism and Its Significance
The radiation adaptive response effect is a biophysical phenomenon responsible for the enhancement of repair processes in irradiated cells. This can be observed in dedicated radiobiological experiments, e.g., where the small priming dose of ionising radiation is given before the high challenging one...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | BioMedInformatics |
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| Online Access: | https://www.mdpi.com/2673-7426/3/1/11 |
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| author | Łukasz Piotrowski Julianna Krasowska Krzysztof W. Fornalski |
| author_facet | Łukasz Piotrowski Julianna Krasowska Krzysztof W. Fornalski |
| author_sort | Łukasz Piotrowski |
| collection | DOAJ |
| description | The radiation adaptive response effect is a biophysical phenomenon responsible for the enhancement of repair processes in irradiated cells. This can be observed in dedicated radiobiological experiments, e.g., where the small priming dose of ionising radiation is given before the high challenging one (the so-called Raper–Yonezawa effect). The situation is more complicated when the whole complex system (the organism) is taken into consideration; many other mechanisms make the adaptive response weaker and—in some cases—practically insignificant. The recently published simplified Monte Carlo model of human lymphocytes irradiation by X-rays allows for the calculation of the level of repair enhancement by the adaptive response when every other cellular biological mechanism is implemented. The qualitative results show that the adaptive response phenomenon, observed with some probability on a basic level, usually blurs among other effects and becomes weaker than expected. Regardless, the radiation adaptive response is still an important biophysical effect which needs to be taken into consideration in low-dose radiobiological studies. |
| first_indexed | 2024-03-11T06:53:34Z |
| format | Article |
| id | doaj.art-6e7e6ad0dd8b414e863bbea2fea0348c |
| institution | Directory Open Access Journal |
| issn | 2673-7426 |
| language | English |
| last_indexed | 2024-03-11T06:53:34Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | BioMedInformatics |
| spelling | doaj.art-6e7e6ad0dd8b414e863bbea2fea0348c2023-11-17T09:48:45ZengMDPI AGBioMedInformatics2673-74262023-02-013115016310.3390/biomedinformatics3010011Mechanistic Modelling of DNA Damage Repair by the Radiation Adaptive Response Mechanism and Its SignificanceŁukasz Piotrowski0Julianna Krasowska1Krzysztof W. Fornalski2Faculty of Physics, Warsaw University of Technology (WF PW), 00-662 Warszawa, PolandFaculty of Physics, Warsaw University of Technology (WF PW), 00-662 Warszawa, PolandFaculty of Physics, Warsaw University of Technology (WF PW), 00-662 Warszawa, PolandThe radiation adaptive response effect is a biophysical phenomenon responsible for the enhancement of repair processes in irradiated cells. This can be observed in dedicated radiobiological experiments, e.g., where the small priming dose of ionising radiation is given before the high challenging one (the so-called Raper–Yonezawa effect). The situation is more complicated when the whole complex system (the organism) is taken into consideration; many other mechanisms make the adaptive response weaker and—in some cases—practically insignificant. The recently published simplified Monte Carlo model of human lymphocytes irradiation by X-rays allows for the calculation of the level of repair enhancement by the adaptive response when every other cellular biological mechanism is implemented. The qualitative results show that the adaptive response phenomenon, observed with some probability on a basic level, usually blurs among other effects and becomes weaker than expected. Regardless, the radiation adaptive response is still an important biophysical effect which needs to be taken into consideration in low-dose radiobiological studies.https://www.mdpi.com/2673-7426/3/1/11adaptive responseradiationradioadaptationlow doseradioadaptive response |
| spellingShingle | Łukasz Piotrowski Julianna Krasowska Krzysztof W. Fornalski Mechanistic Modelling of DNA Damage Repair by the Radiation Adaptive Response Mechanism and Its Significance BioMedInformatics adaptive response radiation radioadaptation low dose radioadaptive response |
| title | Mechanistic Modelling of DNA Damage Repair by the Radiation Adaptive Response Mechanism and Its Significance |
| title_full | Mechanistic Modelling of DNA Damage Repair by the Radiation Adaptive Response Mechanism and Its Significance |
| title_fullStr | Mechanistic Modelling of DNA Damage Repair by the Radiation Adaptive Response Mechanism and Its Significance |
| title_full_unstemmed | Mechanistic Modelling of DNA Damage Repair by the Radiation Adaptive Response Mechanism and Its Significance |
| title_short | Mechanistic Modelling of DNA Damage Repair by the Radiation Adaptive Response Mechanism and Its Significance |
| title_sort | mechanistic modelling of dna damage repair by the radiation adaptive response mechanism and its significance |
| topic | adaptive response radiation radioadaptation low dose radioadaptive response |
| url | https://www.mdpi.com/2673-7426/3/1/11 |
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