Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance
Summary: Patients with COVID-19 can experience symptoms and complications after viral clearance. It is important to identify clinical features of patients who are likely to experience these prolonged effects. We conducted a retrospective study to compare longitudinal laboratory test measurements (he...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221007483 |
| _version_ | 1818431669419376640 |
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| author | Patrick J. Lenehan Eshwan Ramudu A.J. Venkatakrishnan Gabriela Berner Reid McMurry John C. O'Horo Andrew D. Badley William Morice, II John Halamka Venky Soundararajan |
| author_facet | Patrick J. Lenehan Eshwan Ramudu A.J. Venkatakrishnan Gabriela Berner Reid McMurry John C. O'Horo Andrew D. Badley William Morice, II John Halamka Venky Soundararajan |
| author_sort | Patrick J. Lenehan |
| collection | DOAJ |
| description | Summary: Patients with COVID-19 can experience symptoms and complications after viral clearance. It is important to identify clinical features of patients who are likely to experience these prolonged effects. We conducted a retrospective study to compare longitudinal laboratory test measurements (hemoglobin, hematocrit, estimated glomerular filtration rate, serum creatinine, and blood urea nitrogen) in patients rehospitalized after PCR-confirmed SARS-CoV-2 clearance (n = 104) versus patients not rehospitalized after viral clearance (n = 278). Rehospitalized patients had lower median hemoglobin levels in the year prior to COVID-19 diagnosis (Cohen's D = −0.50; p = 1.2 × 10−3) and during their active SARS-CoV-2 infection (Cohen's D = −0.71; p = 4.6 × 10−8). Rehospitalized patients were also more likely to be diagnosed with moderate or severe anemia during their active infection (Odds Ratio = 4.07; p = 4.99 × 10−9). These findings suggest that anemia-related laboratory tests should be considered in risk stratification algorithms for patients with COVID-19. |
| first_indexed | 2024-12-14T15:52:59Z |
| format | Article |
| id | doaj.art-6e7efbe824944f76bfa358a40cf76969 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-14T15:52:59Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-6e7efbe824944f76bfa358a40cf769692022-12-21T22:55:20ZengElsevieriScience2589-00422021-07-01247102780Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearancePatrick J. Lenehan0Eshwan Ramudu1A.J. Venkatakrishnan2Gabriela Berner3Reid McMurry4John C. O'Horo5Andrew D. Badley6William Morice, II7John Halamka8Venky Soundararajan9nference, One Main Street, Cambridge, MA 02142, USAnference, One Main Street, Cambridge, MA 02142, USAnference, One Main Street, Cambridge, MA 02142, USAnference, One Main Street, Cambridge, MA 02142, USAnference, One Main Street, Cambridge, MA 02142, USAMayo Clinic, Rochester, MN 55902, USAMayo Clinic, Rochester, MN 55902, USAMayo Clinic, Rochester, MN 55902, USA; Mayo Clinic Laboratories, Rochester, MN 55902, USAMayo Clinic, Rochester, MN 55902, USAnference, One Main Street, Cambridge, MA 02142, USA; Corresponding authorSummary: Patients with COVID-19 can experience symptoms and complications after viral clearance. It is important to identify clinical features of patients who are likely to experience these prolonged effects. We conducted a retrospective study to compare longitudinal laboratory test measurements (hemoglobin, hematocrit, estimated glomerular filtration rate, serum creatinine, and blood urea nitrogen) in patients rehospitalized after PCR-confirmed SARS-CoV-2 clearance (n = 104) versus patients not rehospitalized after viral clearance (n = 278). Rehospitalized patients had lower median hemoglobin levels in the year prior to COVID-19 diagnosis (Cohen's D = −0.50; p = 1.2 × 10−3) and during their active SARS-CoV-2 infection (Cohen's D = −0.71; p = 4.6 × 10−8). Rehospitalized patients were also more likely to be diagnosed with moderate or severe anemia during their active infection (Odds Ratio = 4.07; p = 4.99 × 10−9). These findings suggest that anemia-related laboratory tests should be considered in risk stratification algorithms for patients with COVID-19.http://www.sciencedirect.com/science/article/pii/S2589004221007483VirologyPathophysiology |
| spellingShingle | Patrick J. Lenehan Eshwan Ramudu A.J. Venkatakrishnan Gabriela Berner Reid McMurry John C. O'Horo Andrew D. Badley William Morice, II John Halamka Venky Soundararajan Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance iScience Virology Pathophysiology |
| title | Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance |
| title_full | Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance |
| title_fullStr | Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance |
| title_full_unstemmed | Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance |
| title_short | Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance |
| title_sort | anemia during sars cov 2 infection is associated with rehospitalization after viral clearance |
| topic | Virology Pathophysiology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004221007483 |
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