Measuring Anxiety-Like Behaviors in Rodent Models of Traumatic Brain Injury
Anxiety is a common complaint following acquired traumatic brain injury (TBI). However, the measurement of dysfunctional anxiety behavioral states following experimental TBI in rodents is complex. Some studies report increased anxiety after TBI, whereas others find a decreased anxiety-like state, of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.682935/full |
| _version_ | 1818999988175241216 |
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| author | Laura B. Tucker Laura B. Tucker Joseph T. McCabe Joseph T. McCabe |
| author_facet | Laura B. Tucker Laura B. Tucker Joseph T. McCabe Joseph T. McCabe |
| author_sort | Laura B. Tucker |
| collection | DOAJ |
| description | Anxiety is a common complaint following acquired traumatic brain injury (TBI). However, the measurement of dysfunctional anxiety behavioral states following experimental TBI in rodents is complex. Some studies report increased anxiety after TBI, whereas others find a decreased anxiety-like state, often described as increased risk-taking behavior or impulsivity. These inconsistencies may reflect a lack of standardization of experimental injury models or of behavioral testing techniques. Here, we review the most commonly employed unconditioned tests of anxiety and discuss them in a context of experimental TBI. Special attention is given to the effects of repeated testing, and consideration of potential sensory and motor confounds in injured rodents. The use of multiple tests and alternative data analysis methods are discussed, as well as the potential for the application of common data elements (CDEs) as a means of providing a format for documentation of experimental details and procedures of each published research report. CDEs may improve the rigor, reproducibility, as well as endpoint for better relating findings with clinical TBI phenotypes and the final goal of translation. While this may not resolve all incongruities in findings across laboratories, it is seen as a way forward for standardized and universal data collection for improvement of data quality and sharing, and advance therapies for neuropsychiatric symptoms that often present for decades following TBI. |
| first_indexed | 2024-12-20T22:26:10Z |
| format | Article |
| id | doaj.art-6e815efcb1de47d9a3edfbfa5b4f2c06 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-20T22:26:10Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-6e815efcb1de47d9a3edfbfa5b4f2c062022-12-21T19:24:49ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532021-10-011510.3389/fnbeh.2021.682935682935Measuring Anxiety-Like Behaviors in Rodent Models of Traumatic Brain InjuryLaura B. Tucker0Laura B. Tucker1Joseph T. McCabe2Joseph T. McCabe3Preclinical Behavior and Models Core, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United StatesDepartment of Anatomy, Physiology and Genetics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United StatesPreclinical Behavior and Models Core, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United StatesDepartment of Anatomy, Physiology and Genetics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United StatesAnxiety is a common complaint following acquired traumatic brain injury (TBI). However, the measurement of dysfunctional anxiety behavioral states following experimental TBI in rodents is complex. Some studies report increased anxiety after TBI, whereas others find a decreased anxiety-like state, often described as increased risk-taking behavior or impulsivity. These inconsistencies may reflect a lack of standardization of experimental injury models or of behavioral testing techniques. Here, we review the most commonly employed unconditioned tests of anxiety and discuss them in a context of experimental TBI. Special attention is given to the effects of repeated testing, and consideration of potential sensory and motor confounds in injured rodents. The use of multiple tests and alternative data analysis methods are discussed, as well as the potential for the application of common data elements (CDEs) as a means of providing a format for documentation of experimental details and procedures of each published research report. CDEs may improve the rigor, reproducibility, as well as endpoint for better relating findings with clinical TBI phenotypes and the final goal of translation. While this may not resolve all incongruities in findings across laboratories, it is seen as a way forward for standardized and universal data collection for improvement of data quality and sharing, and advance therapies for neuropsychiatric symptoms that often present for decades following TBI.https://www.frontiersin.org/articles/10.3389/fnbeh.2021.682935/fullanxietybrain injurybehaviorcommon data elementsopen fieldlight-dark box |
| spellingShingle | Laura B. Tucker Laura B. Tucker Joseph T. McCabe Joseph T. McCabe Measuring Anxiety-Like Behaviors in Rodent Models of Traumatic Brain Injury Frontiers in Behavioral Neuroscience anxiety brain injury behavior common data elements open field light-dark box |
| title | Measuring Anxiety-Like Behaviors in Rodent Models of Traumatic Brain Injury |
| title_full | Measuring Anxiety-Like Behaviors in Rodent Models of Traumatic Brain Injury |
| title_fullStr | Measuring Anxiety-Like Behaviors in Rodent Models of Traumatic Brain Injury |
| title_full_unstemmed | Measuring Anxiety-Like Behaviors in Rodent Models of Traumatic Brain Injury |
| title_short | Measuring Anxiety-Like Behaviors in Rodent Models of Traumatic Brain Injury |
| title_sort | measuring anxiety like behaviors in rodent models of traumatic brain injury |
| topic | anxiety brain injury behavior common data elements open field light-dark box |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.682935/full |
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