Modulation of the Release of a Non-Interacting Low Solubility Drug from Chitosan Pellets Using Different Pellet Size, Composition and Numerical Optimization

Modulation of the Release of a Non-Interacting Low Solubility Drug from Chitosan Pellets Using Different Pellet Size, Composition and Numerical Optimization

Two size classes of piroxicam (PXC) pellets (mini (380–550 μm) and conventional (700–1200 μm)) were prepared using extrusion/spheronization and medium viscosity chitosan (CHS). Mixture experimental design and numerical optimization were applied to distinguish fo...

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Bibliographic Details
Main Authors: Ioannis Partheniadis, Paraskevi Gkogkou, Nikolaos Kantiranis, Ioannis Nikolakakis
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Pharmaceutics
Subjects:
pellets 1
pellet diameter 2
crystallinity 3
sphericity 4
fast release 5
extended release 6
Online Access:https://www.mdpi.com/1999-4923/11/4/175

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