Shared HLA class I and II alleles and clonally restricted public and private brain-infiltrating alpha beta T cells in a cohort of Rasmussen encephalitis surgery patients

Shared HLA class I and II alleles and clonally restricted public and private brain-infiltrating alpha beta T cells in a cohort of Rasmussen encephalitis surgery patients

Rasmussen encephalitis (RE) is a rare pediatric neuroinflammatory disease characterized by intractable seizures and unilateral brain atrophy. T cell infiltrates in affected brain tissue, and the presence of circulating autoantibodies in some RE patients has indicated that RE may be an autoimmune dis...

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Bibliographic Details
Main Authors: Sugandha Dandekar, Hemani Wijesuriya, Tim Geiger, David Hamm, Gary W. Mathern, Geoffrey C. Owens
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Immunology
Subjects:
Autoimmunity
Epilepsy
T cell receptor
human leukocyte antigen
Rasmussen encephalitis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00608/full

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