The role of inhibition in a computational model of an auditory cortical neuron during the encoding of temporal information.
In auditory cortex, temporal information within a sound is represented by two complementary neural codes: a temporal representation based on stimulus-locked firing and a rate representation, where discharge rate co-varies with the timing between acoustic events but lacks a stimulus-synchronized resp...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-04-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1004197 |
| _version_ | 1798025013624832000 |
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| author | Daniel Bendor |
| author_facet | Daniel Bendor |
| author_sort | Daniel Bendor |
| collection | DOAJ |
| description | In auditory cortex, temporal information within a sound is represented by two complementary neural codes: a temporal representation based on stimulus-locked firing and a rate representation, where discharge rate co-varies with the timing between acoustic events but lacks a stimulus-synchronized response. Using a computational neuronal model, we find that stimulus-locked responses are generated when sound-evoked excitation is combined with strong, delayed inhibition. In contrast to this, a non-synchronized rate representation is generated when the net excitation evoked by the sound is weak, which occurs when excitation is coincident and balanced with inhibition. Using single-unit recordings from awake marmosets (Callithrix jacchus), we validate several model predictions, including differences in the temporal fidelity, discharge rates and temporal dynamics of stimulus-evoked responses between neurons with rate and temporal representations. Together these data suggest that feedforward inhibition provides a parsimonious explanation of the neural coding dichotomy observed in auditory cortex. |
| first_indexed | 2024-04-11T18:11:54Z |
| format | Article |
| id | doaj.art-6e86b9a50e4d46ffa03e830500965147 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-04-11T18:11:54Z |
| publishDate | 2015-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-6e86b9a50e4d46ffa03e8305009651472022-12-22T04:10:04ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582015-04-01114e100419710.1371/journal.pcbi.1004197The role of inhibition in a computational model of an auditory cortical neuron during the encoding of temporal information.Daniel BendorIn auditory cortex, temporal information within a sound is represented by two complementary neural codes: a temporal representation based on stimulus-locked firing and a rate representation, where discharge rate co-varies with the timing between acoustic events but lacks a stimulus-synchronized response. Using a computational neuronal model, we find that stimulus-locked responses are generated when sound-evoked excitation is combined with strong, delayed inhibition. In contrast to this, a non-synchronized rate representation is generated when the net excitation evoked by the sound is weak, which occurs when excitation is coincident and balanced with inhibition. Using single-unit recordings from awake marmosets (Callithrix jacchus), we validate several model predictions, including differences in the temporal fidelity, discharge rates and temporal dynamics of stimulus-evoked responses between neurons with rate and temporal representations. Together these data suggest that feedforward inhibition provides a parsimonious explanation of the neural coding dichotomy observed in auditory cortex.https://doi.org/10.1371/journal.pcbi.1004197 |
| spellingShingle | Daniel Bendor The role of inhibition in a computational model of an auditory cortical neuron during the encoding of temporal information. PLoS Computational Biology |
| title | The role of inhibition in a computational model of an auditory cortical neuron during the encoding of temporal information. |
| title_full | The role of inhibition in a computational model of an auditory cortical neuron during the encoding of temporal information. |
| title_fullStr | The role of inhibition in a computational model of an auditory cortical neuron during the encoding of temporal information. |
| title_full_unstemmed | The role of inhibition in a computational model of an auditory cortical neuron during the encoding of temporal information. |
| title_short | The role of inhibition in a computational model of an auditory cortical neuron during the encoding of temporal information. |
| title_sort | role of inhibition in a computational model of an auditory cortical neuron during the encoding of temporal information |
| url | https://doi.org/10.1371/journal.pcbi.1004197 |
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