Comparison of Behavior-Related Features in the MMSE Sentence in Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease
Background: Despite the ubiquity of cognitive assessments using the MMSE, there has been little investigation of currently unscored features of the MMSE sentence item relevant to behavior and language in patients with behavioral variant Frontotemporal Dementia (bvFTD) and Alzheimer’s disease (AD).Ob...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-08-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.733153/full |
| _version_ | 1819119148406407168 |
|---|---|
| author | Ramiro Ruiz-Garcia Ramiro Ruiz-Garcia Soojung Yu Lauryn Richardson Angela Roberts Stephen Pasternak Stephen Pasternak Chloe Stewart Elizabeth Finger Elizabeth Finger |
| author_facet | Ramiro Ruiz-Garcia Ramiro Ruiz-Garcia Soojung Yu Lauryn Richardson Angela Roberts Stephen Pasternak Stephen Pasternak Chloe Stewart Elizabeth Finger Elizabeth Finger |
| author_sort | Ramiro Ruiz-Garcia |
| collection | DOAJ |
| description | Background: Despite the ubiquity of cognitive assessments using the MMSE, there has been little investigation of currently unscored features of the MMSE sentence item relevant to behavior and language in patients with behavioral variant Frontotemporal Dementia (bvFTD) and Alzheimer’s disease (AD).Objective: To describe and compare the unscored content and grammar elements of the MMSE sentence item in patients with bvFTD and AD.Methods: Categorization of predefined content and grammar elements of the MMSE sentence was performed by two blinded raters in patients with bvFTD (n = 74) and AD (n = 84). Chi-square and ANCOVAs were conducted to identify differences between the diagnostic groups. A multinomial logistic regression analysis was conducted to determine whether these features aid in the prediction of diagnosis of bvFTD or AD.Results: A higher proportion of patients with bvFTD wrote sentences addressed to the examiner (22.7% vs. 4.7%, X2 = 11.272, p = 0.001) and about interpersonal relationships (35.3% vs. 16.0%, X2 = 10.139, p = 0.017) in comparison to those with AD. The number of words written was lower in patients with AD and was positively correlated with lower total MMSE scores in AD but not in bvFTD (AD: r = 0.370, p < 0.001; FTD: r = 0.209, p = 0.07). Assessment of the MMSE sentence content and grammar variables did not add to the prediction bvFTD or AD diagnosis beyond the variance explained by age and total MoCA score.Conclusions: Patients with bvFTD and AD showed differences in aspects of the content of the written MMSE sentence item, though these differences did not aid in the diagnosis prediction. |
| first_indexed | 2024-12-22T06:00:10Z |
| format | Article |
| id | doaj.art-6e8794db201441f3a59987a10756641f |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-22T06:00:10Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-6e8794db201441f3a59987a10756641f2022-12-21T18:36:35ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-08-011310.3389/fnagi.2021.733153733153Comparison of Behavior-Related Features in the MMSE Sentence in Behavioral Variant Frontotemporal Dementia and Alzheimer’s DiseaseRamiro Ruiz-Garcia0Ramiro Ruiz-Garcia1Soojung Yu2Lauryn Richardson3Angela Roberts4Stephen Pasternak5Stephen Pasternak6Chloe Stewart7Elizabeth Finger8Elizabeth Finger9Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CanadaCognitive Neurology and Alzheimer Research Centre, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CanadaCognitive Neurology and Alzheimer Research Centre, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CanadaCognitive Neurology and Alzheimer Research Centre, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CanadaPepper School of Communication Sciences and Disorders, Northwestern University, Evanston, IL, United StatesClinical Neurological Sciences, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CanadaCognitive Neurology and Alzheimer Research Centre, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CanadaCognitive Neurology and Alzheimer Research Centre, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CanadaClinical Neurological Sciences, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CanadaCognitive Neurology and Alzheimer Research Centre, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CanadaBackground: Despite the ubiquity of cognitive assessments using the MMSE, there has been little investigation of currently unscored features of the MMSE sentence item relevant to behavior and language in patients with behavioral variant Frontotemporal Dementia (bvFTD) and Alzheimer’s disease (AD).Objective: To describe and compare the unscored content and grammar elements of the MMSE sentence item in patients with bvFTD and AD.Methods: Categorization of predefined content and grammar elements of the MMSE sentence was performed by two blinded raters in patients with bvFTD (n = 74) and AD (n = 84). Chi-square and ANCOVAs were conducted to identify differences between the diagnostic groups. A multinomial logistic regression analysis was conducted to determine whether these features aid in the prediction of diagnosis of bvFTD or AD.Results: A higher proportion of patients with bvFTD wrote sentences addressed to the examiner (22.7% vs. 4.7%, X2 = 11.272, p = 0.001) and about interpersonal relationships (35.3% vs. 16.0%, X2 = 10.139, p = 0.017) in comparison to those with AD. The number of words written was lower in patients with AD and was positively correlated with lower total MMSE scores in AD but not in bvFTD (AD: r = 0.370, p < 0.001; FTD: r = 0.209, p = 0.07). Assessment of the MMSE sentence content and grammar variables did not add to the prediction bvFTD or AD diagnosis beyond the variance explained by age and total MoCA score.Conclusions: Patients with bvFTD and AD showed differences in aspects of the content of the written MMSE sentence item, though these differences did not aid in the diagnosis prediction.https://www.frontiersin.org/articles/10.3389/fnagi.2021.733153/fullbvFTDAlzheimer’s diseasebehaviorMini-Mental State Examination sentencewriting content |
| spellingShingle | Ramiro Ruiz-Garcia Ramiro Ruiz-Garcia Soojung Yu Lauryn Richardson Angela Roberts Stephen Pasternak Stephen Pasternak Chloe Stewart Elizabeth Finger Elizabeth Finger Comparison of Behavior-Related Features in the MMSE Sentence in Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease Frontiers in Aging Neuroscience bvFTD Alzheimer’s disease behavior Mini-Mental State Examination sentence writing content |
| title | Comparison of Behavior-Related Features in the MMSE Sentence in Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease |
| title_full | Comparison of Behavior-Related Features in the MMSE Sentence in Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease |
| title_fullStr | Comparison of Behavior-Related Features in the MMSE Sentence in Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease |
| title_full_unstemmed | Comparison of Behavior-Related Features in the MMSE Sentence in Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease |
| title_short | Comparison of Behavior-Related Features in the MMSE Sentence in Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease |
| title_sort | comparison of behavior related features in the mmse sentence in behavioral variant frontotemporal dementia and alzheimer s disease |
| topic | bvFTD Alzheimer’s disease behavior Mini-Mental State Examination sentence writing content |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.733153/full |
| work_keys_str_mv | AT ramiroruizgarcia comparisonofbehaviorrelatedfeaturesinthemmsesentenceinbehavioralvariantfrontotemporaldementiaandalzheimersdisease AT ramiroruizgarcia comparisonofbehaviorrelatedfeaturesinthemmsesentenceinbehavioralvariantfrontotemporaldementiaandalzheimersdisease AT soojungyu comparisonofbehaviorrelatedfeaturesinthemmsesentenceinbehavioralvariantfrontotemporaldementiaandalzheimersdisease AT laurynrichardson comparisonofbehaviorrelatedfeaturesinthemmsesentenceinbehavioralvariantfrontotemporaldementiaandalzheimersdisease AT angelaroberts comparisonofbehaviorrelatedfeaturesinthemmsesentenceinbehavioralvariantfrontotemporaldementiaandalzheimersdisease AT stephenpasternak comparisonofbehaviorrelatedfeaturesinthemmsesentenceinbehavioralvariantfrontotemporaldementiaandalzheimersdisease AT stephenpasternak comparisonofbehaviorrelatedfeaturesinthemmsesentenceinbehavioralvariantfrontotemporaldementiaandalzheimersdisease AT chloestewart comparisonofbehaviorrelatedfeaturesinthemmsesentenceinbehavioralvariantfrontotemporaldementiaandalzheimersdisease AT elizabethfinger comparisonofbehaviorrelatedfeaturesinthemmsesentenceinbehavioralvariantfrontotemporaldementiaandalzheimersdisease AT elizabethfinger comparisonofbehaviorrelatedfeaturesinthemmsesentenceinbehavioralvariantfrontotemporaldementiaandalzheimersdisease |