Small world network strategies for studying protein structures and binding
Small world network concepts provide many new opportunities to investigate the complex three dimensional structures of protein molecules. This mini-review explores the published literature on using small-world network approaches to study protein structure, with emphasis on the different combination...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-02-01
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| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201302006 |
| _version_ | 1818260912655564800 |
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| author | Neil R Taylor |
| author_facet | Neil R Taylor |
| author_sort | Neil R Taylor |
| collection | DOAJ |
| description | Small world network concepts provide many new opportunities to investigate the complex three dimensional structures of protein molecules. This mini-review explores the published literature on using small-world network approaches to study protein structure, with emphasis on the different combinations of descriptors that have been tested, on studies involving ligand binding in protein-ligand complexes, and on protein-protein complexes. The benefits and success of small world network approaches, which change the focus from specific interactions to the local environment, even to non-local phenomenon, are described. The purpose is to show the different ways that small world network concepts have been used for building new computational models for studying protein structure and function, and for extending and improving existing modelling approaches. |
| first_indexed | 2024-12-12T18:38:52Z |
| format | Article |
| id | doaj.art-6e87a6f4e70e469a886afdfb477a77eb |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-12T18:38:52Z |
| publishDate | 2013-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-6e87a6f4e70e469a886afdfb477a77eb2022-12-22T00:15:42ZengElsevierComputational and Structural Biotechnology Journal2001-03702013-02-0156e201302006Small world network strategies for studying protein structures and bindingNeil R TaylorSmall world network concepts provide many new opportunities to investigate the complex three dimensional structures of protein molecules. This mini-review explores the published literature on using small-world network approaches to study protein structure, with emphasis on the different combinations of descriptors that have been tested, on studies involving ligand binding in protein-ligand complexes, and on protein-protein complexes. The benefits and success of small world network approaches, which change the focus from specific interactions to the local environment, even to non-local phenomenon, are described. The purpose is to show the different ways that small world network concepts have been used for building new computational models for studying protein structure and function, and for extending and improving existing modelling approaches.http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201302006Small world networkprotein structureprotein-ligand bindingprotein-protein binding |
| spellingShingle | Neil R Taylor Small world network strategies for studying protein structures and binding Computational and Structural Biotechnology Journal Small world network protein structure protein-ligand binding protein-protein binding |
| title | Small world network strategies for studying protein structures and binding |
| title_full | Small world network strategies for studying protein structures and binding |
| title_fullStr | Small world network strategies for studying protein structures and binding |
| title_full_unstemmed | Small world network strategies for studying protein structures and binding |
| title_short | Small world network strategies for studying protein structures and binding |
| title_sort | small world network strategies for studying protein structures and binding |
| topic | Small world network protein structure protein-ligand binding protein-protein binding |
| url | http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201302006 |
| work_keys_str_mv | AT neilrtaylor smallworldnetworkstrategiesforstudyingproteinstructuresandbinding |