Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder
Abstract Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we meas...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-023-00492-2 |
| _version_ | 1797426614524444672 |
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| author | Luca Baldelli Chiara Pirazzini Luisa Sambati Francesco Ravaioli Davide Gentilini Giovanna Calandra-Buonaura Pietro Guaraldi Claudio Franceschi Pietro Cortelli Paolo Garagnani Maria Giulia Bacalini Federica Provini |
| author_facet | Luca Baldelli Chiara Pirazzini Luisa Sambati Francesco Ravaioli Davide Gentilini Giovanna Calandra-Buonaura Pietro Guaraldi Claudio Franceschi Pietro Cortelli Paolo Garagnani Maria Giulia Bacalini Federica Provini |
| author_sort | Luca Baldelli |
| collection | DOAJ |
| description | Abstract Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured biological aging in videopolysomnography confirmed iRBD patients, videopolysomnography-negative and population-based controls. We found that iRBDs tended to be epigenetically older than controls, suggesting that accelerated aging characterizes prodromal neurodegeneration. |
| first_indexed | 2024-03-09T08:32:49Z |
| format | Article |
| id | doaj.art-6e884a80cc894b9782345da85797f7bd |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-09T08:32:49Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-6e884a80cc894b9782345da85797f7bd2023-12-02T19:13:54ZengNature Portfolionpj Parkinson's Disease2373-80572023-03-01911410.1038/s41531-023-00492-2Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior DisorderLuca Baldelli0Chiara Pirazzini1Luisa Sambati2Francesco Ravaioli3Davide Gentilini4Giovanna Calandra-Buonaura5Pietro Guaraldi6Claudio Franceschi7Pietro Cortelli8Paolo Garagnani9Maria Giulia Bacalini10Federica Provini11Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of BolognaDepartment of Medical and Surgical Sciences (DIMEC), University of BolognaIRCCS Istituto delle Scienze Neurologiche di BolognaDepartment of Medical and Surgical Sciences (DIMEC), University of BolognaDepartment of Brain and Behavioral Sciences, University of PaviaDepartment of Biomedical and NeuroMotor Sciences (DiBiNeM), University of BolognaIRCCS Istituto delle Scienze Neurologiche di BolognaDepartment of Medical and Surgical Sciences (DIMEC), University of BolognaDepartment of Biomedical and NeuroMotor Sciences (DiBiNeM), University of BolognaDepartment of Medical and Surgical Sciences (DIMEC), University of BolognaIRCCS Istituto delle Scienze Neurologiche di BolognaDepartment of Biomedical and NeuroMotor Sciences (DiBiNeM), University of BolognaAbstract Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured biological aging in videopolysomnography confirmed iRBD patients, videopolysomnography-negative and population-based controls. We found that iRBDs tended to be epigenetically older than controls, suggesting that accelerated aging characterizes prodromal neurodegeneration.https://doi.org/10.1038/s41531-023-00492-2 |
| spellingShingle | Luca Baldelli Chiara Pirazzini Luisa Sambati Francesco Ravaioli Davide Gentilini Giovanna Calandra-Buonaura Pietro Guaraldi Claudio Franceschi Pietro Cortelli Paolo Garagnani Maria Giulia Bacalini Federica Provini Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder npj Parkinson's Disease |
| title | Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder |
| title_full | Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder |
| title_fullStr | Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder |
| title_full_unstemmed | Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder |
| title_short | Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder |
| title_sort | epigenetic clocks suggest accelerated aging in patients with isolated rem sleep behavior disorder |
| url | https://doi.org/10.1038/s41531-023-00492-2 |
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