Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder

Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder

Abstract Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we meas...

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Main Authors: Luca Baldelli, Chiara Pirazzini, Luisa Sambati, Francesco Ravaioli, Davide Gentilini, Giovanna Calandra-Buonaura, Pietro Guaraldi, Claudio Franceschi, Pietro Cortelli, Paolo Garagnani, Maria Giulia Bacalini, Federica Provini
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00492-2

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