Donors for nerve transplantation in craniofacial soft tissue injuries
Neural tissue is an important soft tissue; for instance, craniofacial nerves govern several aspects of human behavior, including the expression of speech, emotion transmission, sensation, and motor function. Therefore, nerve repair to promote functional recovery after craniofacial soft tissue injuri...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.978980/full |
| _version_ | 1818482263805919232 |
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| author | Sishuai Sun Sishuai Sun Di Lu Di Lu Hanlin Zhong Hanlin Zhong Chao Li Chao Li Ning Yang Ning Yang Bin Huang Bin Huang Shilei Ni Shilei Ni Xingang Li Xingang Li |
| author_facet | Sishuai Sun Sishuai Sun Di Lu Di Lu Hanlin Zhong Hanlin Zhong Chao Li Chao Li Ning Yang Ning Yang Bin Huang Bin Huang Shilei Ni Shilei Ni Xingang Li Xingang Li |
| author_sort | Sishuai Sun |
| collection | DOAJ |
| description | Neural tissue is an important soft tissue; for instance, craniofacial nerves govern several aspects of human behavior, including the expression of speech, emotion transmission, sensation, and motor function. Therefore, nerve repair to promote functional recovery after craniofacial soft tissue injuries is indispensable. However, the repair and regeneration of craniofacial nerves are challenging due to their intricate anatomical and physiological characteristics. Currently, nerve transplantation is an irreplaceable treatment for segmental nerve defects. With the development of emerging technologies, transplantation donors have become more diverse. The present article reviews the traditional and emerging alternative materials aimed at advancing cutting-edge research on craniofacial nerve repair and facilitating the transition from the laboratory to the clinic. It also provides a reference for donor selection for nerve repair after clinical craniofacial soft tissue injuries. We found that autografts are still widely accepted as the first options for segmental nerve defects. However, allogeneic composite functional units have a strong advantage for nerve transplantation for nerve defects accompanied by several tissue damages or loss. As an alternative to autografts, decellularized tissue has attracted increasing attention because of its low immunogenicity. Nerve conduits have been developed from traditional autologous tissue to composite conduits based on various synthetic materials, with developments in tissue engineering technology. Nerve conduits have great potential to replace traditional donors because their structures are more consistent with the physiological microenvironment and show self-regulation performance with improvements in 3D technology. New materials, such as hydrogels and nanomaterials, have attracted increasing attention in the biomedical field. Their biocompatibility and stimuli-responsiveness have been gradually explored by researchers in the regeneration and regulation of neural networks. |
| first_indexed | 2024-12-10T11:45:26Z |
| format | Article |
| id | doaj.art-6e8ba70a89a04318a92f6b8d925967f4 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-10T11:45:26Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-6e8ba70a89a04318a92f6b8d925967f42022-12-22T01:50:06ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.978980978980Donors for nerve transplantation in craniofacial soft tissue injuriesSishuai Sun0Sishuai Sun1Di Lu2Di Lu3Hanlin Zhong4Hanlin Zhong5Chao Li6Chao Li7Ning Yang8Ning Yang9Bin Huang10Bin Huang11Shilei Ni12Shilei Ni13Xingang Li14Xingang Li15Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, ChinaNeural tissue is an important soft tissue; for instance, craniofacial nerves govern several aspects of human behavior, including the expression of speech, emotion transmission, sensation, and motor function. Therefore, nerve repair to promote functional recovery after craniofacial soft tissue injuries is indispensable. However, the repair and regeneration of craniofacial nerves are challenging due to their intricate anatomical and physiological characteristics. Currently, nerve transplantation is an irreplaceable treatment for segmental nerve defects. With the development of emerging technologies, transplantation donors have become more diverse. The present article reviews the traditional and emerging alternative materials aimed at advancing cutting-edge research on craniofacial nerve repair and facilitating the transition from the laboratory to the clinic. It also provides a reference for donor selection for nerve repair after clinical craniofacial soft tissue injuries. We found that autografts are still widely accepted as the first options for segmental nerve defects. However, allogeneic composite functional units have a strong advantage for nerve transplantation for nerve defects accompanied by several tissue damages or loss. As an alternative to autografts, decellularized tissue has attracted increasing attention because of its low immunogenicity. Nerve conduits have been developed from traditional autologous tissue to composite conduits based on various synthetic materials, with developments in tissue engineering technology. Nerve conduits have great potential to replace traditional donors because their structures are more consistent with the physiological microenvironment and show self-regulation performance with improvements in 3D technology. New materials, such as hydrogels and nanomaterials, have attracted increasing attention in the biomedical field. Their biocompatibility and stimuli-responsiveness have been gradually explored by researchers in the regeneration and regulation of neural networks.https://www.frontiersin.org/articles/10.3389/fbioe.2022.978980/fullsoft tissue injuriesnerve transplantationBiomaterialstissue engineeringRegenerative medicinenerve conduit |
| spellingShingle | Sishuai Sun Sishuai Sun Di Lu Di Lu Hanlin Zhong Hanlin Zhong Chao Li Chao Li Ning Yang Ning Yang Bin Huang Bin Huang Shilei Ni Shilei Ni Xingang Li Xingang Li Donors for nerve transplantation in craniofacial soft tissue injuries Frontiers in Bioengineering and Biotechnology soft tissue injuries nerve transplantation Biomaterials tissue engineering Regenerative medicine nerve conduit |
| title | Donors for nerve transplantation in craniofacial soft tissue injuries |
| title_full | Donors for nerve transplantation in craniofacial soft tissue injuries |
| title_fullStr | Donors for nerve transplantation in craniofacial soft tissue injuries |
| title_full_unstemmed | Donors for nerve transplantation in craniofacial soft tissue injuries |
| title_short | Donors for nerve transplantation in craniofacial soft tissue injuries |
| title_sort | donors for nerve transplantation in craniofacial soft tissue injuries |
| topic | soft tissue injuries nerve transplantation Biomaterials tissue engineering Regenerative medicine nerve conduit |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.978980/full |
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