In vitro study of the PLLA-Mg65Zn30Ca5 composites as potential biodegradable materials for bone implants
PLLA-magnesium composites have been widely investigated as potential biodegradable materials for bone implants. Lower/higher corrosion resistance of the crystalized/amorphous magnesium alloys allows tailoring of biodegradability rate. In this work, the amorphous Mg65Zn30Ca5 was investigated versus t...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2021-11-01
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| Series: | Journal of Magnesium and Alloys |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956721000293 |
| _version_ | 1797203708245704704 |
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| author | Taolei Wang Chao Lin Dan Batalu Lu Zhang Jingzhou Hu Wei Lu |
| author_facet | Taolei Wang Chao Lin Dan Batalu Lu Zhang Jingzhou Hu Wei Lu |
| author_sort | Taolei Wang |
| collection | DOAJ |
| description | PLLA-magnesium composites have been widely investigated as potential biodegradable materials for bone implants. Lower/higher corrosion resistance of the crystalized/amorphous magnesium alloys allows tailoring of biodegradability rate. In this work, the amorphous Mg65Zn30Ca5 was investigated versus traditional crystalized Mg65Zn30Ca5, and a PLLA-Mg65Zn30Ca5 composite has been successfully fabricated using hot injection process. Furthermore, the high corrosion resistance of the amorphous Mg65Zn30Ca5 prevented the high alkalization and deterioration of mechanical strength. In addition, the high Zn content intended to improve the glass forming ability, also enhances the anti-bacterial property of the PLLA-Mg65Zn30Ca5 composite. The remarkable performance of the PLLA-Mg65Zn30Ca5 composite shows its promising application in bone repair and tissue regeneration. |
| first_indexed | 2024-04-24T08:23:37Z |
| format | Article |
| id | doaj.art-6e8be07db1234673bf26e84ba8b824d4 |
| institution | Directory Open Access Journal |
| issn | 2213-9567 |
| language | English |
| last_indexed | 2024-04-24T08:23:37Z |
| publishDate | 2021-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Magnesium and Alloys |
| spelling | doaj.art-6e8be07db1234673bf26e84ba8b824d42024-04-16T23:57:13ZengKeAi Communications Co., Ltd.Journal of Magnesium and Alloys2213-95672021-11-019620092018In vitro study of the PLLA-Mg65Zn30Ca5 composites as potential biodegradable materials for bone implantsTaolei Wang0Chao Lin1Dan Batalu2Lu Zhang3Jingzhou Hu4Wei Lu5Institute for Regenerative Medicine, Shanghai East Hospital, School of Materials Science and Engineering, Tongji University, Shanghai 200123, ChinaDepartment of Oral & Maxillofacial-Head & Neck Oncology, Ninth People's Hospital, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai 200011, China; School of Stomatology, Weifang Medical University, Weifang 261000, ChinaUniversity Politehnica of Bucharest, Splaiul Independentei 313, Bucharest 060042, RomaniaShanghai Key Lab of D&A for Metal Functional Materials, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Science and Technology, Tongji University, Shanghai 200123, ChinaDepartment of Oral & Maxillofacial-Head & Neck Oncology, Ninth People's Hospital, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai 200011, ChinaInstitute for Regenerative Medicine, Shanghai East Hospital, School of Materials Science and Engineering, Tongji University, Shanghai 200123, China; Corresponding author.PLLA-magnesium composites have been widely investigated as potential biodegradable materials for bone implants. Lower/higher corrosion resistance of the crystalized/amorphous magnesium alloys allows tailoring of biodegradability rate. In this work, the amorphous Mg65Zn30Ca5 was investigated versus traditional crystalized Mg65Zn30Ca5, and a PLLA-Mg65Zn30Ca5 composite has been successfully fabricated using hot injection process. Furthermore, the high corrosion resistance of the amorphous Mg65Zn30Ca5 prevented the high alkalization and deterioration of mechanical strength. In addition, the high Zn content intended to improve the glass forming ability, also enhances the anti-bacterial property of the PLLA-Mg65Zn30Ca5 composite. The remarkable performance of the PLLA-Mg65Zn30Ca5 composite shows its promising application in bone repair and tissue regeneration.http://www.sciencedirect.com/science/article/pii/S2213956721000293Polymer-matrix composites (PMCs)Magnesium glassesCorrosionMechanical properties |
| spellingShingle | Taolei Wang Chao Lin Dan Batalu Lu Zhang Jingzhou Hu Wei Lu In vitro study of the PLLA-Mg65Zn30Ca5 composites as potential biodegradable materials for bone implants Journal of Magnesium and Alloys Polymer-matrix composites (PMCs) Magnesium glasses Corrosion Mechanical properties |
| title | In vitro study of the PLLA-Mg65Zn30Ca5 composites as potential biodegradable materials for bone implants |
| title_full | In vitro study of the PLLA-Mg65Zn30Ca5 composites as potential biodegradable materials for bone implants |
| title_fullStr | In vitro study of the PLLA-Mg65Zn30Ca5 composites as potential biodegradable materials for bone implants |
| title_full_unstemmed | In vitro study of the PLLA-Mg65Zn30Ca5 composites as potential biodegradable materials for bone implants |
| title_short | In vitro study of the PLLA-Mg65Zn30Ca5 composites as potential biodegradable materials for bone implants |
| title_sort | in vitro study of the plla mg65zn30ca5 composites as potential biodegradable materials for bone implants |
| topic | Polymer-matrix composites (PMCs) Magnesium glasses Corrosion Mechanical properties |
| url | http://www.sciencedirect.com/science/article/pii/S2213956721000293 |
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