Genomic and Transcriptomic Research in the Discovery and Application of Colorectal Cancer Circulating Markers
Colorectal cancer (CRC) is the most frequently occurring malignancy in the world. However, the mortality from CRC can be reduced through early diagnostics, selection of the most effective treatment, observation of the therapy success, and the earliest possible diagnosis of recurrences. A comprehensi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/15/12407 |
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| author | Anastasia A. Ponomaryova Elena Yu. Rykova Anastasia I. Solovyova Anna S. Tarasova Dmitry N. Kostromitsky Alexey Yu. Dobrodeev Sergey A. Afanasiev Nadezhda V. Cherdyntseva |
| author_facet | Anastasia A. Ponomaryova Elena Yu. Rykova Anastasia I. Solovyova Anna S. Tarasova Dmitry N. Kostromitsky Alexey Yu. Dobrodeev Sergey A. Afanasiev Nadezhda V. Cherdyntseva |
| author_sort | Anastasia A. Ponomaryova |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the most frequently occurring malignancy in the world. However, the mortality from CRC can be reduced through early diagnostics, selection of the most effective treatment, observation of the therapy success, and the earliest possible diagnosis of recurrences. A comprehensive analysis of genetic and epigenetic factors contributing to the CRC development is needed to refine diagnostic, therapeutic, and preventive strategies and to ensure appropriate decision making in managing specific CRC cases. The liquid biopsy approach utilizing circulating markers has demonstrated its good performance as a tool to detect the changes in the molecular pathways associated with various cancers. In this review, we attempted to brief the main tendencies in the development of circulating DNA and RNA-based markers in CRC such as cancer-associated DNA mutations, DNA methylation changes, and non-coding RNA expression shifts. Attention is devoted to the existing circulating nucleic acid-based CRC markers, the possibility of their application in clinical practice today, and their future improvement. Approaches to the discovery and verification of new markers are described, and the existing problems and potential solutions for them are highlighted. |
| first_indexed | 2024-03-11T00:25:28Z |
| format | Article |
| id | doaj.art-6e8c6395da7d4a75bd482fe6e5f1b700 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T00:25:28Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6e8c6395da7d4a75bd482fe6e5f1b7002023-11-18T23:04:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124151240710.3390/ijms241512407Genomic and Transcriptomic Research in the Discovery and Application of Colorectal Cancer Circulating MarkersAnastasia A. Ponomaryova0Elena Yu. Rykova1Anastasia I. Solovyova2Anna S. Tarasova3Dmitry N. Kostromitsky4Alexey Yu. Dobrodeev5Sergey A. Afanasiev6Nadezhda V. Cherdyntseva7Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634009 Tomsk, RussiaInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, RussiaDepartment of Biochemistry, Medico-Biological Faculty, Siberian State Medical University, 634050 Tomsk, RussiaCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634009 Tomsk, RussiaCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634009 Tomsk, RussiaCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634009 Tomsk, RussiaCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634009 Tomsk, RussiaCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634009 Tomsk, RussiaColorectal cancer (CRC) is the most frequently occurring malignancy in the world. However, the mortality from CRC can be reduced through early diagnostics, selection of the most effective treatment, observation of the therapy success, and the earliest possible diagnosis of recurrences. A comprehensive analysis of genetic and epigenetic factors contributing to the CRC development is needed to refine diagnostic, therapeutic, and preventive strategies and to ensure appropriate decision making in managing specific CRC cases. The liquid biopsy approach utilizing circulating markers has demonstrated its good performance as a tool to detect the changes in the molecular pathways associated with various cancers. In this review, we attempted to brief the main tendencies in the development of circulating DNA and RNA-based markers in CRC such as cancer-associated DNA mutations, DNA methylation changes, and non-coding RNA expression shifts. Attention is devoted to the existing circulating nucleic acid-based CRC markers, the possibility of their application in clinical practice today, and their future improvement. Approaches to the discovery and verification of new markers are described, and the existing problems and potential solutions for them are highlighted.https://www.mdpi.com/1422-0067/24/15/12407colorectal cancerdiagnosisprognosisprediction of therapy responsecirculating DNAscirculating RNAs |
| spellingShingle | Anastasia A. Ponomaryova Elena Yu. Rykova Anastasia I. Solovyova Anna S. Tarasova Dmitry N. Kostromitsky Alexey Yu. Dobrodeev Sergey A. Afanasiev Nadezhda V. Cherdyntseva Genomic and Transcriptomic Research in the Discovery and Application of Colorectal Cancer Circulating Markers International Journal of Molecular Sciences colorectal cancer diagnosis prognosis prediction of therapy response circulating DNAs circulating RNAs |
| title | Genomic and Transcriptomic Research in the Discovery and Application of Colorectal Cancer Circulating Markers |
| title_full | Genomic and Transcriptomic Research in the Discovery and Application of Colorectal Cancer Circulating Markers |
| title_fullStr | Genomic and Transcriptomic Research in the Discovery and Application of Colorectal Cancer Circulating Markers |
| title_full_unstemmed | Genomic and Transcriptomic Research in the Discovery and Application of Colorectal Cancer Circulating Markers |
| title_short | Genomic and Transcriptomic Research in the Discovery and Application of Colorectal Cancer Circulating Markers |
| title_sort | genomic and transcriptomic research in the discovery and application of colorectal cancer circulating markers |
| topic | colorectal cancer diagnosis prognosis prediction of therapy response circulating DNAs circulating RNAs |
| url | https://www.mdpi.com/1422-0067/24/15/12407 |
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