Use of complementary and alternative medicine and adherence to antiepileptic drug therapy among epilepsy patients: a systematic review
Muhammad Junaid Farrukh,1 Mohd Makmor-Bakry,1 Ernieda Hatah,1 Hui Jan Tan2 1Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 2Faculty of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Kuala Lumpur, Malaysia Purpose: To identify the use pattern of comp...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-10-01
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| Series: | Patient Preference and Adherence |
| Subjects: | |
| Online Access: | https://www.dovepress.com/use-of-complementary-and-alternative-medicine-and-adherence-to-antiepi-peer-reviewed-article-PPA |
| _version_ | 1828837240019615744 |
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| author | Farrukh MJ Makmor-Bakry M Hatah E Tan HJ |
| author_facet | Farrukh MJ Makmor-Bakry M Hatah E Tan HJ |
| author_sort | Farrukh MJ |
| collection | DOAJ |
| description | Muhammad Junaid Farrukh,1 Mohd Makmor-Bakry,1 Ernieda Hatah,1 Hui Jan Tan2 1Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 2Faculty of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Kuala Lumpur, Malaysia Purpose: To identify the use pattern of complementary and alternative medicine (CAM) and its impact on antiepileptic drug (AED) adherence among patients with epilepsy. Method: Potential studies were identified through a systematic search of Scopus, Science Direct, Google Scholar, and PubMed. The keywords used to identify relevant articles were “adherence,” “AED,” “epilepsy,” “non-adherence,” and “complementary and alternative medicine.” An article was included in the review if the study met the following criteria: 1) conducted in epilepsy patients, 2) conducted in patients aged 18 years and above, 3) conducted in patients prescribed AEDs, and 4) patients’ adherence to AEDs. Results: A total of 3,330 studies were identified and 30 were included in the final analysis. The review found that the AED non-adherence rate reported in the studies was between 25% and 66%. The percentage of CAM use was found to be between 7.5% and 73.3%. The most common reason for inadequate AED therapy and higher dependence on CAM was the patients’ belief that epilepsy had a spiritual or psychological cause, rather than primarily being a disease of the brain. Other factors for AED non-adherence were forgetfulness, specific beliefs about medications, depression, uncontrolled recent seizures, and frequent medication dosage. Conclusion: The review found a high prevalence of CAM use and non-adherence to AEDs among epilepsy patients. However, a limited number of studies have investigated the association between CAM usage and AED adherence. Future studies may wish to explore the influence of CAM use on AED medication adherence. Keywords: medication adherence, AED, epilepsy, complementary and alternative medicine, non-compliance, CAM, seizure |
| first_indexed | 2024-12-12T18:36:40Z |
| format | Article |
| id | doaj.art-6e8ca68da0d54154a4cecd9cd92676c7 |
| institution | Directory Open Access Journal |
| issn | 1177-889X |
| language | English |
| last_indexed | 2024-12-12T18:36:40Z |
| publishDate | 2018-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj.art-6e8ca68da0d54154a4cecd9cd92676c72022-12-22T00:15:46ZengDove Medical PressPatient Preference and Adherence1177-889X2018-10-01Volume 122111212141384Use of complementary and alternative medicine and adherence to antiepileptic drug therapy among epilepsy patients: a systematic reviewFarrukh MJMakmor-Bakry MHatah ETan HJMuhammad Junaid Farrukh,1 Mohd Makmor-Bakry,1 Ernieda Hatah,1 Hui Jan Tan2 1Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 2Faculty of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Kuala Lumpur, Malaysia Purpose: To identify the use pattern of complementary and alternative medicine (CAM) and its impact on antiepileptic drug (AED) adherence among patients with epilepsy. Method: Potential studies were identified through a systematic search of Scopus, Science Direct, Google Scholar, and PubMed. The keywords used to identify relevant articles were “adherence,” “AED,” “epilepsy,” “non-adherence,” and “complementary and alternative medicine.” An article was included in the review if the study met the following criteria: 1) conducted in epilepsy patients, 2) conducted in patients aged 18 years and above, 3) conducted in patients prescribed AEDs, and 4) patients’ adherence to AEDs. Results: A total of 3,330 studies were identified and 30 were included in the final analysis. The review found that the AED non-adherence rate reported in the studies was between 25% and 66%. The percentage of CAM use was found to be between 7.5% and 73.3%. The most common reason for inadequate AED therapy and higher dependence on CAM was the patients’ belief that epilepsy had a spiritual or psychological cause, rather than primarily being a disease of the brain. Other factors for AED non-adherence were forgetfulness, specific beliefs about medications, depression, uncontrolled recent seizures, and frequent medication dosage. Conclusion: The review found a high prevalence of CAM use and non-adherence to AEDs among epilepsy patients. However, a limited number of studies have investigated the association between CAM usage and AED adherence. Future studies may wish to explore the influence of CAM use on AED medication adherence. Keywords: medication adherence, AED, epilepsy, complementary and alternative medicine, non-compliance, CAM, seizurehttps://www.dovepress.com/use-of-complementary-and-alternative-medicine-and-adherence-to-antiepi-peer-reviewed-article-PPAMedication adherenceAEDepilepsycomplementary and alternative medicine |
| spellingShingle | Farrukh MJ Makmor-Bakry M Hatah E Tan HJ Use of complementary and alternative medicine and adherence to antiepileptic drug therapy among epilepsy patients: a systematic review Patient Preference and Adherence Medication adherence AED epilepsy complementary and alternative medicine |
| title | Use of complementary and alternative medicine and adherence to antiepileptic drug therapy among epilepsy patients: a systematic review |
| title_full | Use of complementary and alternative medicine and adherence to antiepileptic drug therapy among epilepsy patients: a systematic review |
| title_fullStr | Use of complementary and alternative medicine and adherence to antiepileptic drug therapy among epilepsy patients: a systematic review |
| title_full_unstemmed | Use of complementary and alternative medicine and adherence to antiepileptic drug therapy among epilepsy patients: a systematic review |
| title_short | Use of complementary and alternative medicine and adherence to antiepileptic drug therapy among epilepsy patients: a systematic review |
| title_sort | use of complementary and alternative medicine and adherence to antiepileptic drug therapy among epilepsy patients a systematic review |
| topic | Medication adherence AED epilepsy complementary and alternative medicine |
| url | https://www.dovepress.com/use-of-complementary-and-alternative-medicine-and-adherence-to-antiepi-peer-reviewed-article-PPA |
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