Target Identification of 22-(4-Pyridinecarbonyl) Jorunnamycin A, a Tetrahydroisoquinoline Derivative from the Sponge <i>Xestospongia</i> sp., in Mediating Non-Small-Cell Lung Cancer Cell Apoptosis

Target Identification of 22-(4-Pyridinecarbonyl) Jorunnamycin A, a Tetrahydroisoquinoline Derivative from the Sponge <i>Xestospongia</i> sp., in Mediating Non-Small-Cell Lung Cancer Cell Apoptosis

A dysregulation of the cell-death mechanism contributes to poor prognosis in lung cancer. New potent chemotherapeutic agents targeting apoptosis-deregulating molecules have been discovered. In this study, 22-(4-pyridinecarbonyl) jorunnamycin A (22-(4′py)-JA), a synthetic derivative of bistetrahydroi...

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Bibliographic Details
Main Authors: Iksen Iksen, Suwimon Sinsook, Onsurang Wattanathamsan, Koonchira Buaban, Supakarn Chamni, Varisa Pongrakhananon
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
22-(4-pyridinecarbonyl) jorunnamycin A
apoptosis
mitogen-activated protein kinase
network pharmacology
non-small cell lung cancer
Online Access:https://www.mdpi.com/1420-3049/27/24/8948

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