Ophthatome™: an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic
Abstract Background Medical big data analytics has revolutionized the human healthcare system by introducing processes that facilitate rationale clinical decision making, predictive or prognostic modelling of the disease progression and management, disease surveillance, overall impact on public heal...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12886-020-01705-5 |
| _version_ | 1819172364344098816 |
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| author | Praveen Raj Sushma Tejwani Dandayudhapani Sudha B. Muthu Narayanan Chandrasekar Thangapandi Sankar Das J. Somasekar Susmithasane Mangalapudi Durgesh Kumar Narendra Pindipappanahalli Rohit Shetty Arkasubhra Ghosh Govindasamy Kumaramanickavel Amitabha Chaudhuri Nagasamy Soumittra |
| author_facet | Praveen Raj Sushma Tejwani Dandayudhapani Sudha B. Muthu Narayanan Chandrasekar Thangapandi Sankar Das J. Somasekar Susmithasane Mangalapudi Durgesh Kumar Narendra Pindipappanahalli Rohit Shetty Arkasubhra Ghosh Govindasamy Kumaramanickavel Amitabha Chaudhuri Nagasamy Soumittra |
| author_sort | Praveen Raj |
| collection | DOAJ |
| description | Abstract Background Medical big data analytics has revolutionized the human healthcare system by introducing processes that facilitate rationale clinical decision making, predictive or prognostic modelling of the disease progression and management, disease surveillance, overall impact on public health and research. Although, the electronic medical records (EMR) system is the digital storehouse of rich medical data of a large patient cohort collected over many years, the data lack sufficient structure to be of clinical value for applying deep learning methods and advanced analytics to improve disease management at an individual patient level or for the discipline in general. Ophthatome™ captures data contained in retrospective electronic medical records between September 2012 and January 2018 to facilitate translational vision research through a knowledgebase of ophthalmic diseases. Methods The electronic medical records data from Narayana Nethralaya ophthalmic hospital recorded in the MS-SQL database was mapped and programmatically transferred to MySQL. The captured data was manually curated to preserve data integrity and accuracy. The data was stored in MySQL database management system for ease of visualization, advanced search functions and other knowledgebase applications. Results Ophthatome™ is a comprehensive and accurate knowledgebase of ophthalmic diseases containing curated clinical, treatment and imaging data of 581,466 ophthalmic subjects from the Indian population, recorded between September 2012 and January 2018. Ophthatome™ provides filters and Boolean searches with operators and modifiers that allow selection of specific cohorts covering 524 distinct ophthalmic disease types and 1800 disease sub-types across 35 different anatomical regions of the eye. The availability of longitudinal data for about 300,000 subjects provides additional opportunity to perform clinical research on disease progression and management including drug responses and management outcomes. The knowledgebase captures ophthalmic diseases in a genetically diverse population providing opportunity to study genetic and environmental factors contributing to or influencing ophthalmic diseases. Conclusion Ophthatome™ will accelerate clinical, genomic, pharmacogenomic and advanced translational research in ophthalmology and vision sciences. |
| first_indexed | 2024-12-22T20:06:00Z |
| format | Article |
| id | doaj.art-6e90d3688f4544e2bcdc159d2bc61cd6 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-22T20:06:00Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-6e90d3688f4544e2bcdc159d2bc61cd62022-12-21T18:14:08ZengBMCBMC Ophthalmology1471-24152020-11-0120111110.1186/s12886-020-01705-5Ophthatome™: an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinicPraveen Raj0Sushma Tejwani1Dandayudhapani Sudha2B. Muthu Narayanan3Chandrasekar Thangapandi4Sankar Das5J. Somasekar6Susmithasane Mangalapudi7Durgesh Kumar8Narendra Pindipappanahalli9Rohit Shetty10Arkasubhra Ghosh11Govindasamy Kumaramanickavel12Amitabha Chaudhuri13Nagasamy Soumittra14MedGenome Labs LimitedNarayana NethralayaMedGenome Labs LimitedMedGenome Labs LimitedMedGenome Labs LimitedNarayana NethralayaMedGenome Labs LimitedMedGenome Labs LimitedMedGenome Labs LimitedNarayana NethralayaNarayana NethralayaGROW lab, Narayana Nethrayala FoundationGROW lab, Narayana Nethrayala FoundationMedGenome IncMedGenome Labs LimitedAbstract Background Medical big data analytics has revolutionized the human healthcare system by introducing processes that facilitate rationale clinical decision making, predictive or prognostic modelling of the disease progression and management, disease surveillance, overall impact on public health and research. Although, the electronic medical records (EMR) system is the digital storehouse of rich medical data of a large patient cohort collected over many years, the data lack sufficient structure to be of clinical value for applying deep learning methods and advanced analytics to improve disease management at an individual patient level or for the discipline in general. Ophthatome™ captures data contained in retrospective electronic medical records between September 2012 and January 2018 to facilitate translational vision research through a knowledgebase of ophthalmic diseases. Methods The electronic medical records data from Narayana Nethralaya ophthalmic hospital recorded in the MS-SQL database was mapped and programmatically transferred to MySQL. The captured data was manually curated to preserve data integrity and accuracy. The data was stored in MySQL database management system for ease of visualization, advanced search functions and other knowledgebase applications. Results Ophthatome™ is a comprehensive and accurate knowledgebase of ophthalmic diseases containing curated clinical, treatment and imaging data of 581,466 ophthalmic subjects from the Indian population, recorded between September 2012 and January 2018. Ophthatome™ provides filters and Boolean searches with operators and modifiers that allow selection of specific cohorts covering 524 distinct ophthalmic disease types and 1800 disease sub-types across 35 different anatomical regions of the eye. The availability of longitudinal data for about 300,000 subjects provides additional opportunity to perform clinical research on disease progression and management including drug responses and management outcomes. The knowledgebase captures ophthalmic diseases in a genetically diverse population providing opportunity to study genetic and environmental factors contributing to or influencing ophthalmic diseases. Conclusion Ophthatome™ will accelerate clinical, genomic, pharmacogenomic and advanced translational research in ophthalmology and vision sciences.http://link.springer.com/article/10.1186/s12886-020-01705-5OphthatomeKnowledge baseElectronic medical recordsCurated clinical dataDefined cohortVision sciences |
| spellingShingle | Praveen Raj Sushma Tejwani Dandayudhapani Sudha B. Muthu Narayanan Chandrasekar Thangapandi Sankar Das J. Somasekar Susmithasane Mangalapudi Durgesh Kumar Narendra Pindipappanahalli Rohit Shetty Arkasubhra Ghosh Govindasamy Kumaramanickavel Amitabha Chaudhuri Nagasamy Soumittra Ophthatome™: an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic BMC Ophthalmology Ophthatome Knowledge base Electronic medical records Curated clinical data Defined cohort Vision sciences |
| title | Ophthatome™: an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic |
| title_full | Ophthatome™: an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic |
| title_fullStr | Ophthatome™: an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic |
| title_full_unstemmed | Ophthatome™: an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic |
| title_short | Ophthatome™: an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic |
| title_sort | ophthatome™ an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic |
| topic | Ophthatome Knowledge base Electronic medical records Curated clinical data Defined cohort Vision sciences |
| url | http://link.springer.com/article/10.1186/s12886-020-01705-5 |
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