Selection and Identification of Skeletal-Muscle-Targeted RNA Aptamers

Selection and Identification of Skeletal-Muscle-Targeted RNA Aptamers

Oligonucleotide gene therapy has shown great promise for the treatment of muscular dystrophies. Nevertheless, the selective delivery to affected muscles has shown to be challenging because of their high representation in the body and the high complexity of their cell membranes. Current trials show l...

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Bibliographic Details
Main Authors: Styliana Philippou, Nikolaos P. Mastroyiannopoulos, Neoklis Makrides, Carsten W. Lederer, Marina Kleanthous, Leonidas A. Phylactou
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
aptamer
SELEX
skeletal muscle
delivery
muscular dystrophies
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117303025

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