Protein-centric omics analysis reveals circulating complements linked to non-viral liver diseases as potential therapeutic targets

Protein-centric omics analysis reveals circulating complements linked to non-viral liver diseases as potential therapeutic targets

Background/Aims To evaluate the causal correlation between complement components and non-viral liver diseases and their potential use as druggable targets. Methods We conducted Mendelian randomization (MR) to assess the causal role of circulating complements in the risk of non-viral liver diseases....

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Bibliographic Details
Main Authors: Yingzhou Shi, Hang Dong, Shiwei Sun, Xiaoqin Wu, Jiansong Fang, Jianbo Zhao, Junming Han, Zongyue Li, Huixiao Wu, Luna Liu, Wanhong Wu, Yang Tian, Guandou Yuan, Xiude Fan, Chao Xu
Format: Article
Language:English
Published: Korean Association for the Study of the Liver 2024-01-01
Series:Clinical and Molecular Hepatology
Subjects:
liver diseases
complement system proteins
mendelian randomization analysis
drug repositioning
Online Access:http://e-cmh.org/upload/pdf/cmh-2023-0343.pdf

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