Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression
Royal jelly (RJ) is secreted by honeybees and has been used as an apitherapy to obtain healthy skin since ancient times. However, the mechanism of the protective effects of RJ against skin aging and skin diseases caused by skin stress and its components have not been clarified. In this study, we att...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/23/12973 |
| _version_ | 1797507710157062144 |
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| author | Nobuaki Okumura Takashi Ito Tomomi Degawa Mariko Moriyama Hiroyuki Moriyama |
| author_facet | Nobuaki Okumura Takashi Ito Tomomi Degawa Mariko Moriyama Hiroyuki Moriyama |
| author_sort | Nobuaki Okumura |
| collection | DOAJ |
| description | Royal jelly (RJ) is secreted by honeybees and has been used as an apitherapy to obtain healthy skin since ancient times. However, the mechanism of the protective effects of RJ against skin aging and skin diseases caused by skin stress and its components have not been clarified. In this study, we attempted to understand the effect of RJ on epidermal function and observed that NAD(P)H quinone dehydrogenase 1 (NQO1) is significantly induced by RJ in keratinocytes. The expression of NQO1 was also increased in the 3D epidermal skin model. NQO1 is involved in antioxidation and detoxification metabolism, and we found that RJ protects against the epidermal stress caused by UVB and menadione through the upregulation of NQO1. We identified 10-hydroxy-2-decenoic acid (10H2DA), a major fatty acid in RJ, as an active compound in this reaction as it induced the expression of NQO1 and protected the skin against oxidative stress. We demonstrated that the protective effect of RJ against epidermal stress is mediated through the upregulation of NQO1 by 10H2DA. |
| first_indexed | 2024-03-10T04:52:18Z |
| format | Article |
| id | doaj.art-6e958dd3c45e4f12bd7bd35e40c92f1a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:52:18Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6e958dd3c45e4f12bd7bd35e40c92f1a2023-11-23T02:31:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122231297310.3390/ijms222312973Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 ExpressionNobuaki Okumura0Takashi Ito1Tomomi Degawa2Mariko Moriyama3Hiroyuki Moriyama4Institute for Bee Products and Health Science, Yamada Bee Company Inc., Tomata-gun, Okayama 708-0393, JapanInstitute for Bee Products and Health Science, Yamada Bee Company Inc., Tomata-gun, Okayama 708-0393, JapanInstitute for Bee Products and Health Science, Yamada Bee Company Inc., Tomata-gun, Okayama 708-0393, JapanPharmaceutical Research and Technology Institute, Kindai University, Higashi-Osaka, Osaka 577-8502, JapanPharmaceutical Research and Technology Institute, Kindai University, Higashi-Osaka, Osaka 577-8502, JapanRoyal jelly (RJ) is secreted by honeybees and has been used as an apitherapy to obtain healthy skin since ancient times. However, the mechanism of the protective effects of RJ against skin aging and skin diseases caused by skin stress and its components have not been clarified. In this study, we attempted to understand the effect of RJ on epidermal function and observed that NAD(P)H quinone dehydrogenase 1 (NQO1) is significantly induced by RJ in keratinocytes. The expression of NQO1 was also increased in the 3D epidermal skin model. NQO1 is involved in antioxidation and detoxification metabolism, and we found that RJ protects against the epidermal stress caused by UVB and menadione through the upregulation of NQO1. We identified 10-hydroxy-2-decenoic acid (10H2DA), a major fatty acid in RJ, as an active compound in this reaction as it induced the expression of NQO1 and protected the skin against oxidative stress. We demonstrated that the protective effect of RJ against epidermal stress is mediated through the upregulation of NQO1 by 10H2DA.https://www.mdpi.com/1422-0067/22/23/12973royal jellyfatty acidskeratinocyteanti-oxidantNAD(P)H quinone dehydrogenase 1 (NQO1) |
| spellingShingle | Nobuaki Okumura Takashi Ito Tomomi Degawa Mariko Moriyama Hiroyuki Moriyama Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression International Journal of Molecular Sciences royal jelly fatty acids keratinocyte anti-oxidant NAD(P)H quinone dehydrogenase 1 (NQO1) |
| title | Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression |
| title_full | Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression |
| title_fullStr | Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression |
| title_full_unstemmed | Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression |
| title_short | Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression |
| title_sort | royal jelly protects against epidermal stress through upregulation of the nqo1 expression |
| topic | royal jelly fatty acids keratinocyte anti-oxidant NAD(P)H quinone dehydrogenase 1 (NQO1) |
| url | https://www.mdpi.com/1422-0067/22/23/12973 |
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