Immunization of Mice with Anthrax Protective Antigen Limits Cardiotoxicity but Not Hepatotoxicity Following Lethal Toxin Challenge

Immunization of Mice with Anthrax Protective Antigen Limits Cardiotoxicity but Not Hepatotoxicity Following Lethal Toxin Challenge

Protective immunity against anthrax is inferred from measurement of vaccine antigen-specific neutralizing antibody titers in serum samples. In animal models, in vivo challenges with toxin and/or spores can also be performed. However, neither of these approaches considers toxin-induced damage to spec...

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Bibliographic Details
Main Authors: T. Scott Devera, Dawn K. Prusator, Sunil K. Joshi, Jimmy D. Ballard, Mark L. Lang
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Toxins
Subjects:
Bacillus anthracis
lethal toxin
protective antigen
neutralizing antibody
troponin
Online Access:http://www.mdpi.com/2072-6651/7/7/2371

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