A Ca<sup>2+</sup>-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics

A Ca<sup>2+</sup>-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics

Keratins exert important structural but also cytoprotective functions. They have to be adaptable to support cellular homeostasis. Epiplakin (EPPK1) has been shown to decorate keratin filaments in epithelial cells and to play a protective role under stress, but the mechanism is still unclear. Using l...

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Bibliographic Details
Main Authors: Sonia Ratajczyk, Corinne Drexler, Reinhard Windoffer, Rudolf E. Leube, Peter Fuchs
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
cytoskeleton
keratin
intermediate filaments
plakin protein family
epiplakin
Online Access:https://www.mdpi.com/2073-4409/11/19/3077

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