The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice
Aggravation of liver steatosis shifts the hepatocellular death mode from apoptosis to necroptosis in acute and chronic liver damage. Here the authors report that the transcription factor ATF3 regulates this shift through the induction of RIPK3, a regulator of necroptosis.
Main Authors: | Yuka Inaba, Emi Hashiuchi, Hitoshi Watanabe, Kumi Kimura, Yu Oshima, Kohsuke Tsuchiya, Shin Murai, Chiaki Takahashi, Michihiro Matsumoto, Shigetaka Kitajima, Yasuhiko Yamamoto, Masao Honda, Shun-ichiro Asahara, Kim Ravnskjaer, Shin-ichi Horike, Shuichi Kaneko, Masato Kasuga, Hiroyasu Nakano, Kenichi Harada, Hiroshi Inoue |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-01-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-35804-w |
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