Nedocromil sodium and diphenhydramine HCl ameliorate exercise‐induced arterial hypoxemia in highly trained athletes
Abstract Introduction Exercise‐induced arterial hypoxemia (EIAH) has been observed in highly trained endurance athletes during near maximal exercise, which may be influenced by a histamine‐mediated inflammatory response at the pulmonary capillary‐alveolar membrane. In order to test this hypothesis,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15149 |
| _version_ | 1818953742158921728 |
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| author | Michael A. Coyle Curtis S. Goss Wesley J. Manz Joel T. Greenshields Robert F. Chapman Joel M. Stager |
| author_facet | Michael A. Coyle Curtis S. Goss Wesley J. Manz Joel T. Greenshields Robert F. Chapman Joel M. Stager |
| author_sort | Michael A. Coyle |
| collection | DOAJ |
| description | Abstract Introduction Exercise‐induced arterial hypoxemia (EIAH) has been observed in highly trained endurance athletes during near maximal exercise, which may be influenced by a histamine‐mediated inflammatory response at the pulmonary capillary‐alveolar membrane. In order to test this hypothesis, we examined whether the mast cell stabilizer nedocromil sodium (NS) and H1‐receptor antagonist diphenhydramine HCL (DH) would ameliorate EIAH and mitigate the drop in arterial oxyhemoglobin saturation (SaO2) during intensive exercise. Methods Seven highly trained male cross country runners (age, 21 ± 2 years; V̇O2max, 74.7 ± 3.5 ml·kg−1·min−1) participated in the study. All subjects completed a maximal exercise treadmill test to exhaustion, followed by three 5‐min constant‐load exercise bouts at 70%, 80%, and 90% V̇O2max. Prior to testing, subjects received either placebo (PL), NS, or DH. Results Compared to PL, there was a significant treatment effect on SaO2 (p < 0.001) for both NS and DH during both constant‐load exercise and at V̇O2max. Post hoc tests revealed SaO2 values, compared to PL, were significantly higher at V̇O2max and during DH trials and higher with NS at constant‐load intensities except at 70% (p = 0.13). Conclusion The findings provide further evidence that histamine contributes directly or indirectly to the development of EIAH during intense exercise in highly trained athletes. |
| first_indexed | 2024-12-20T10:11:06Z |
| format | Article |
| id | doaj.art-6e972a29559845c3866833a294a43932 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-20T10:11:06Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-6e972a29559845c3866833a294a439322022-12-21T19:44:08ZengWileyPhysiological Reports2051-817X2022-01-01101n/an/a10.14814/phy2.15149Nedocromil sodium and diphenhydramine HCl ameliorate exercise‐induced arterial hypoxemia in highly trained athletesMichael A. Coyle0Curtis S. Goss1Wesley J. Manz2Joel T. Greenshields3Robert F. Chapman4Joel M. Stager5HH Morris Human Performance Laboratory, Department of Kinesiology, School of Public Health Indiana University Bloomington Indiana USAHH Morris Human Performance Laboratory, Department of Kinesiology, School of Public Health Indiana University Bloomington Indiana USAHH Morris Human Performance Laboratory, Department of Kinesiology, School of Public Health Indiana University Bloomington Indiana USAHH Morris Human Performance Laboratory, Department of Kinesiology, School of Public Health Indiana University Bloomington Indiana USAHH Morris Human Performance Laboratory, Department of Kinesiology, School of Public Health Indiana University Bloomington Indiana USAHH Morris Human Performance Laboratory, Department of Kinesiology, School of Public Health Indiana University Bloomington Indiana USAAbstract Introduction Exercise‐induced arterial hypoxemia (EIAH) has been observed in highly trained endurance athletes during near maximal exercise, which may be influenced by a histamine‐mediated inflammatory response at the pulmonary capillary‐alveolar membrane. In order to test this hypothesis, we examined whether the mast cell stabilizer nedocromil sodium (NS) and H1‐receptor antagonist diphenhydramine HCL (DH) would ameliorate EIAH and mitigate the drop in arterial oxyhemoglobin saturation (SaO2) during intensive exercise. Methods Seven highly trained male cross country runners (age, 21 ± 2 years; V̇O2max, 74.7 ± 3.5 ml·kg−1·min−1) participated in the study. All subjects completed a maximal exercise treadmill test to exhaustion, followed by three 5‐min constant‐load exercise bouts at 70%, 80%, and 90% V̇O2max. Prior to testing, subjects received either placebo (PL), NS, or DH. Results Compared to PL, there was a significant treatment effect on SaO2 (p < 0.001) for both NS and DH during both constant‐load exercise and at V̇O2max. Post hoc tests revealed SaO2 values, compared to PL, were significantly higher at V̇O2max and during DH trials and higher with NS at constant‐load intensities except at 70% (p = 0.13). Conclusion The findings provide further evidence that histamine contributes directly or indirectly to the development of EIAH during intense exercise in highly trained athletes.https://doi.org/10.14814/phy2.15149blood‐gas barriergas exchangehistamineinterstitial pulmonary edema |
| spellingShingle | Michael A. Coyle Curtis S. Goss Wesley J. Manz Joel T. Greenshields Robert F. Chapman Joel M. Stager Nedocromil sodium and diphenhydramine HCl ameliorate exercise‐induced arterial hypoxemia in highly trained athletes Physiological Reports blood‐gas barrier gas exchange histamine interstitial pulmonary edema |
| title | Nedocromil sodium and diphenhydramine HCl ameliorate exercise‐induced arterial hypoxemia in highly trained athletes |
| title_full | Nedocromil sodium and diphenhydramine HCl ameliorate exercise‐induced arterial hypoxemia in highly trained athletes |
| title_fullStr | Nedocromil sodium and diphenhydramine HCl ameliorate exercise‐induced arterial hypoxemia in highly trained athletes |
| title_full_unstemmed | Nedocromil sodium and diphenhydramine HCl ameliorate exercise‐induced arterial hypoxemia in highly trained athletes |
| title_short | Nedocromil sodium and diphenhydramine HCl ameliorate exercise‐induced arterial hypoxemia in highly trained athletes |
| title_sort | nedocromil sodium and diphenhydramine hcl ameliorate exercise induced arterial hypoxemia in highly trained athletes |
| topic | blood‐gas barrier gas exchange histamine interstitial pulmonary edema |
| url | https://doi.org/10.14814/phy2.15149 |
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