Diagnostic Value of <sup>18</sup>F-FDG PET/MRI for Revised 2018 FIGO Staging in Patients with Cervical Cancer
Purpose: To evaluate the diagnostic potential of PET/MRI with <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) in cervical cancer based on the revised 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system. Materials and Methods: Seventy-two pa...
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MDPI AG
2021-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/2/202 |
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| author | Hideaki Tsuyoshi Tetsuya Tsujikawa Shizuka Yamada Hidehiko Okazawa Yoshio Yoshida |
| author_facet | Hideaki Tsuyoshi Tetsuya Tsujikawa Shizuka Yamada Hidehiko Okazawa Yoshio Yoshida |
| author_sort | Hideaki Tsuyoshi |
| collection | DOAJ |
| description | Purpose: To evaluate the diagnostic potential of PET/MRI with <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) in cervical cancer based on the revised 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system. Materials and Methods: Seventy-two patients with biopsy-proven primary cervical cancer underwent pretreatment <sup>18</sup>F-FDG PET/MRI, CT, and pelvic MRI. The diagnostic performance of <sup>18</sup>F-FDG PET/MRI and MRI for assessing extent of the primary tumor and <sup>18</sup>F-FDG PET/MRI and CT for assessing nodal and distant metastases was evaluated by two experienced readers. Histopathological and follow-up imaging results were used as the gold standard. McNemar test was employed for statistical analysis. Results: Accuracy for the invasion of vagina, parametrium, side wall, and adjacent organs was 97.2%, 93.1%, 97.2%, and 100% for <sup>18</sup>F-FDG PET/MRI; and 97.2%, 91.7%, 97.2%, and 100% for pelvic MRI, respectively (<i>p</i> > 0.05). Patient-based accuracy for metastasis to pelvic and paraaortic lymph nodes and distant organs was 95.8%, 98.6%, and 100% for <sup>18</sup>F-FDG PET/MRI; and 83.3%, 95.8%, and 97.2% for CT, respectively; metastasis to pelvic lymph nodes was statistically significant (<i>p</i> < 0.01). Lesion-based sensitivity, specificity, and accuracy for lymph nodes were 83.3%, 95.9%, and 94.8% for <sup>18</sup>F-FDG PET/MRI; and 29.2%, 98.9% and 93.1% for CT, respectively; sensitivity was statistically significant (<i>p</i> < 0.001). After excluding patients diagnosed by conization, accuracy for revised FIGO staging 2018 was significantly better for <sup>18</sup>F-FDG PET/MRI (82.1%) than for CT and MRI (60.7%) (<i>p</i> < 0.01). Conclusions: <sup>18</sup>F-FDG PET/MRI offers higher diagnostic value for revised 2018 FIGO staging, suggesting that <sup>18</sup>F-FDG PET/MRI might provide an optimal diagnostic strategy for preoperative staging. |
| first_indexed | 2024-03-09T03:16:59Z |
| format | Article |
| id | doaj.art-6e97d7c0f4584edc945a93d45e48dd3d |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T03:16:59Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj.art-6e97d7c0f4584edc945a93d45e48dd3d2023-12-03T15:18:01ZengMDPI AGDiagnostics2075-44182021-01-0111220210.3390/diagnostics11020202Diagnostic Value of <sup>18</sup>F-FDG PET/MRI for Revised 2018 FIGO Staging in Patients with Cervical CancerHideaki Tsuyoshi0Tetsuya Tsujikawa1Shizuka Yamada2Hidehiko Okazawa3Yoshio Yoshida4Department of Obstetrics and Gynecology, University of Fukui, Fukui 910-1193, JapanBiomedical Imaging Research Center, University of Fukui, Fukui 910-1193, JapanDepartment of Obstetrics and Gynecology, University of Fukui, Fukui 910-1193, JapanBiomedical Imaging Research Center, University of Fukui, Fukui 910-1193, JapanDepartment of Obstetrics and Gynecology, University of Fukui, Fukui 910-1193, JapanPurpose: To evaluate the diagnostic potential of PET/MRI with <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) in cervical cancer based on the revised 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system. Materials and Methods: Seventy-two patients with biopsy-proven primary cervical cancer underwent pretreatment <sup>18</sup>F-FDG PET/MRI, CT, and pelvic MRI. The diagnostic performance of <sup>18</sup>F-FDG PET/MRI and MRI for assessing extent of the primary tumor and <sup>18</sup>F-FDG PET/MRI and CT for assessing nodal and distant metastases was evaluated by two experienced readers. Histopathological and follow-up imaging results were used as the gold standard. McNemar test was employed for statistical analysis. Results: Accuracy for the invasion of vagina, parametrium, side wall, and adjacent organs was 97.2%, 93.1%, 97.2%, and 100% for <sup>18</sup>F-FDG PET/MRI; and 97.2%, 91.7%, 97.2%, and 100% for pelvic MRI, respectively (<i>p</i> > 0.05). Patient-based accuracy for metastasis to pelvic and paraaortic lymph nodes and distant organs was 95.8%, 98.6%, and 100% for <sup>18</sup>F-FDG PET/MRI; and 83.3%, 95.8%, and 97.2% for CT, respectively; metastasis to pelvic lymph nodes was statistically significant (<i>p</i> < 0.01). Lesion-based sensitivity, specificity, and accuracy for lymph nodes were 83.3%, 95.9%, and 94.8% for <sup>18</sup>F-FDG PET/MRI; and 29.2%, 98.9% and 93.1% for CT, respectively; sensitivity was statistically significant (<i>p</i> < 0.001). After excluding patients diagnosed by conization, accuracy for revised FIGO staging 2018 was significantly better for <sup>18</sup>F-FDG PET/MRI (82.1%) than for CT and MRI (60.7%) (<i>p</i> < 0.01). Conclusions: <sup>18</sup>F-FDG PET/MRI offers higher diagnostic value for revised 2018 FIGO staging, suggesting that <sup>18</sup>F-FDG PET/MRI might provide an optimal diagnostic strategy for preoperative staging.https://www.mdpi.com/2075-4418/11/2/202<sup>18</sup>F-FDG PET/MRICTMRIcervical cancerrevised 2018 FIGO staging |
| spellingShingle | Hideaki Tsuyoshi Tetsuya Tsujikawa Shizuka Yamada Hidehiko Okazawa Yoshio Yoshida Diagnostic Value of <sup>18</sup>F-FDG PET/MRI for Revised 2018 FIGO Staging in Patients with Cervical Cancer Diagnostics <sup>18</sup>F-FDG PET/MRI CT MRI cervical cancer revised 2018 FIGO staging |
| title | Diagnostic Value of <sup>18</sup>F-FDG PET/MRI for Revised 2018 FIGO Staging in Patients with Cervical Cancer |
| title_full | Diagnostic Value of <sup>18</sup>F-FDG PET/MRI for Revised 2018 FIGO Staging in Patients with Cervical Cancer |
| title_fullStr | Diagnostic Value of <sup>18</sup>F-FDG PET/MRI for Revised 2018 FIGO Staging in Patients with Cervical Cancer |
| title_full_unstemmed | Diagnostic Value of <sup>18</sup>F-FDG PET/MRI for Revised 2018 FIGO Staging in Patients with Cervical Cancer |
| title_short | Diagnostic Value of <sup>18</sup>F-FDG PET/MRI for Revised 2018 FIGO Staging in Patients with Cervical Cancer |
| title_sort | diagnostic value of sup 18 sup f fdg pet mri for revised 2018 figo staging in patients with cervical cancer |
| topic | <sup>18</sup>F-FDG PET/MRI CT MRI cervical cancer revised 2018 FIGO staging |
| url | https://www.mdpi.com/2075-4418/11/2/202 |
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