Cytomegalovirus as a novel target for immunotherapy of glioblastoma multiforme
Progress in the treatment of glioblastoma multiforme (GBM) over the last few decades has remained marginal and GBM is still universally fatal with short survival times after initial diagnosis. Much research is focused on finding new therapeutics for GBM and immune based approaches have shown great p...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-10-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00275/full |
| _version_ | 1819259645729964032 |
|---|---|
| author | Andrea eSchuessler David eWalker Rajiv eKhanna |
| author_facet | Andrea eSchuessler David eWalker Rajiv eKhanna |
| author_sort | Andrea eSchuessler |
| collection | DOAJ |
| description | Progress in the treatment of glioblastoma multiforme (GBM) over the last few decades has remained marginal and GBM is still universally fatal with short survival times after initial diagnosis. Much research is focused on finding new therapeutics for GBM and immune based approaches have shown great promise. The detection of cytomegalovirus (CMV) antigens in malignant cells has suggested that treatment strategies based on immunological intervention, such as adoptive transfer of antiviral T cells or vaccination with viral epitopes, could be exploited as cancer therapy. We review here the rationale for using CMV as a therapeutic target and discuss the first clinical evidence for safety and efficacy of CMV specific cellular immunotherapy for GBM. |
| first_indexed | 2024-12-23T19:13:18Z |
| format | Article |
| id | doaj.art-6e988d7b0a0c4e4b9c39cd87e875e6c5 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T19:13:18Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-6e988d7b0a0c4e4b9c39cd87e875e6c52022-12-21T17:34:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2014-10-01410.3389/fonc.2014.00275112214Cytomegalovirus as a novel target for immunotherapy of glioblastoma multiformeAndrea eSchuessler0David eWalker1Rajiv eKhanna2QIMR Berghofer Medical Research InstituteNewro FoundationQIMR Berghofer Medical Research InstituteProgress in the treatment of glioblastoma multiforme (GBM) over the last few decades has remained marginal and GBM is still universally fatal with short survival times after initial diagnosis. Much research is focused on finding new therapeutics for GBM and immune based approaches have shown great promise. The detection of cytomegalovirus (CMV) antigens in malignant cells has suggested that treatment strategies based on immunological intervention, such as adoptive transfer of antiviral T cells or vaccination with viral epitopes, could be exploited as cancer therapy. We review here the rationale for using CMV as a therapeutic target and discuss the first clinical evidence for safety and efficacy of CMV specific cellular immunotherapy for GBM.http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00275/fullAdoptive TransferCytomegalovirusImmunotherapyT cellglioblastoma multiforme (GBM)checkpoint modulators |
| spellingShingle | Andrea eSchuessler David eWalker Rajiv eKhanna Cytomegalovirus as a novel target for immunotherapy of glioblastoma multiforme Frontiers in Oncology Adoptive Transfer Cytomegalovirus Immunotherapy T cell glioblastoma multiforme (GBM) checkpoint modulators |
| title | Cytomegalovirus as a novel target for immunotherapy of glioblastoma multiforme |
| title_full | Cytomegalovirus as a novel target for immunotherapy of glioblastoma multiforme |
| title_fullStr | Cytomegalovirus as a novel target for immunotherapy of glioblastoma multiforme |
| title_full_unstemmed | Cytomegalovirus as a novel target for immunotherapy of glioblastoma multiforme |
| title_short | Cytomegalovirus as a novel target for immunotherapy of glioblastoma multiforme |
| title_sort | cytomegalovirus as a novel target for immunotherapy of glioblastoma multiforme |
| topic | Adoptive Transfer Cytomegalovirus Immunotherapy T cell glioblastoma multiforme (GBM) checkpoint modulators |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00275/full |
| work_keys_str_mv | AT andreaeschuessler cytomegalovirusasanoveltargetforimmunotherapyofglioblastomamultiforme AT davidewalker cytomegalovirusasanoveltargetforimmunotherapyofglioblastomamultiforme AT rajivekhanna cytomegalovirusasanoveltargetforimmunotherapyofglioblastomamultiforme |