<i>Lactiplantibacillus plantarum</i> MG4296 and <i>Lacticaseibacillus paracasei</i> MG5012 Ameliorates Insulin Resistance in Palmitic Acid-Induced HepG2 Cells and High Fat Diet-Induced Mice
The purpose of this study was to evaluate the capacity of <i>Lactiplantibacillus plantarum</i> MG4296 (MG4296) and <i>Lacticaseibacillus paracasei</i> MG5012 (MG5012) on insulin resistance (IR) and diabetes-related metabolic changes in palmitic acid (PA)-induced HepG2 cells a...
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MDPI AG
2021-05-01
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author | Gayeong Won Soo-Im Choi Chang-Ho Kang Gun-Hee Kim |
author_facet | Gayeong Won Soo-Im Choi Chang-Ho Kang Gun-Hee Kim |
author_sort | Gayeong Won |
collection | DOAJ |
description | The purpose of this study was to evaluate the capacity of <i>Lactiplantibacillus plantarum</i> MG4296 (MG4296) and <i>Lacticaseibacillus paracasei</i> MG5012 (MG5012) on insulin resistance (IR) and diabetes-related metabolic changes in palmitic acid (PA)-induced HepG2 cells and high-fat diet-induced mice. In vitro, cell-free extracts of MG4296 and MG5012 alleviated IR by increasing glucose uptake and glycogen content in PA-induced insulin-resistant HepG2 cells. In vivo, MG4296 and MG5012 supplementation markedly decreased body weight and glucose tolerance. Administration of both strains also improved serum glucose, glycated hemoglobin, insulin, triglyceride, LDL/HDL ratio, and homeostatic model assessment of IR (HOMA-IR). Histopathological analysis of liver tissue demonstrated a significant reduction in lipid accumulation and glycogen content. Moreover, MG4296 and MG5012 treatment enhanced phosphoinositide-3 kinase (PI3K)/protein kinase B (Akt) expression in the liver. Overall, MG4296 and MG5012 could prevent HFD-induced glucose tolerance and hyperglycemia by improving IR. Therefore, <i>L. plantarum</i> MG4296 and <i>L. paracasei</i> MG5012 could be useful as new probiotics candidates to improve T2DM. |
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spelling | doaj.art-6e9891f96be94fc1aecb16363d14d9322023-11-21T21:21:01ZengMDPI AGMicroorganisms2076-26072021-05-0196113910.3390/microorganisms9061139<i>Lactiplantibacillus plantarum</i> MG4296 and <i>Lacticaseibacillus paracasei</i> MG5012 Ameliorates Insulin Resistance in Palmitic Acid-Induced HepG2 Cells and High Fat Diet-Induced MiceGayeong Won0Soo-Im Choi1Chang-Ho Kang2Gun-Hee Kim3Department of Health Functional New Materials, Duksung Women’s University, Seoul 01369, KoreaDepartment of Health Functional New Materials, Duksung Women’s University, Seoul 01369, KoreaMediogen, Co., Ltd., Seoul 04146, KoreaDepartment of Food and Nutrition, Duksung Women’s University, Seoul 01369, KoreaThe purpose of this study was to evaluate the capacity of <i>Lactiplantibacillus plantarum</i> MG4296 (MG4296) and <i>Lacticaseibacillus paracasei</i> MG5012 (MG5012) on insulin resistance (IR) and diabetes-related metabolic changes in palmitic acid (PA)-induced HepG2 cells and high-fat diet-induced mice. In vitro, cell-free extracts of MG4296 and MG5012 alleviated IR by increasing glucose uptake and glycogen content in PA-induced insulin-resistant HepG2 cells. In vivo, MG4296 and MG5012 supplementation markedly decreased body weight and glucose tolerance. Administration of both strains also improved serum glucose, glycated hemoglobin, insulin, triglyceride, LDL/HDL ratio, and homeostatic model assessment of IR (HOMA-IR). Histopathological analysis of liver tissue demonstrated a significant reduction in lipid accumulation and glycogen content. Moreover, MG4296 and MG5012 treatment enhanced phosphoinositide-3 kinase (PI3K)/protein kinase B (Akt) expression in the liver. Overall, MG4296 and MG5012 could prevent HFD-induced glucose tolerance and hyperglycemia by improving IR. Therefore, <i>L. plantarum</i> MG4296 and <i>L. paracasei</i> MG5012 could be useful as new probiotics candidates to improve T2DM.https://www.mdpi.com/2076-2607/9/6/1139<i>Lactiplantibacillus plantarum</i> MG4296<i>Lacticaseibacillus paracasei</i> MG5012insulin resistancediabetesPI3K/Akt |
spellingShingle | Gayeong Won Soo-Im Choi Chang-Ho Kang Gun-Hee Kim <i>Lactiplantibacillus plantarum</i> MG4296 and <i>Lacticaseibacillus paracasei</i> MG5012 Ameliorates Insulin Resistance in Palmitic Acid-Induced HepG2 Cells and High Fat Diet-Induced Mice Microorganisms <i>Lactiplantibacillus plantarum</i> MG4296 <i>Lacticaseibacillus paracasei</i> MG5012 insulin resistance diabetes PI3K/Akt |
title | <i>Lactiplantibacillus plantarum</i> MG4296 and <i>Lacticaseibacillus paracasei</i> MG5012 Ameliorates Insulin Resistance in Palmitic Acid-Induced HepG2 Cells and High Fat Diet-Induced Mice |
title_full | <i>Lactiplantibacillus plantarum</i> MG4296 and <i>Lacticaseibacillus paracasei</i> MG5012 Ameliorates Insulin Resistance in Palmitic Acid-Induced HepG2 Cells and High Fat Diet-Induced Mice |
title_fullStr | <i>Lactiplantibacillus plantarum</i> MG4296 and <i>Lacticaseibacillus paracasei</i> MG5012 Ameliorates Insulin Resistance in Palmitic Acid-Induced HepG2 Cells and High Fat Diet-Induced Mice |
title_full_unstemmed | <i>Lactiplantibacillus plantarum</i> MG4296 and <i>Lacticaseibacillus paracasei</i> MG5012 Ameliorates Insulin Resistance in Palmitic Acid-Induced HepG2 Cells and High Fat Diet-Induced Mice |
title_short | <i>Lactiplantibacillus plantarum</i> MG4296 and <i>Lacticaseibacillus paracasei</i> MG5012 Ameliorates Insulin Resistance in Palmitic Acid-Induced HepG2 Cells and High Fat Diet-Induced Mice |
title_sort | i lactiplantibacillus plantarum i mg4296 and i lacticaseibacillus paracasei i mg5012 ameliorates insulin resistance in palmitic acid induced hepg2 cells and high fat diet induced mice |
topic | <i>Lactiplantibacillus plantarum</i> MG4296 <i>Lacticaseibacillus paracasei</i> MG5012 insulin resistance diabetes PI3K/Akt |
url | https://www.mdpi.com/2076-2607/9/6/1139 |
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