Bringing a genomic perspective to the safety of drug treatment in oncology [version 1; referees: 3 approved]
This article describes the clinical relevance of toxicity of therapies administered to patients with cancer, putting the patient, rather than disease, at the center of the evaluation of safety of anti-cancer therapy. Hence, the implications of adverse events are described from the patient perspectiv...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-03-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/6-385/v1 |
| _version_ | 1818329249969340416 |
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| author | Federico Innocenti |
| author_facet | Federico Innocenti |
| author_sort | Federico Innocenti |
| collection | DOAJ |
| description | This article describes the clinical relevance of toxicity of therapies administered to patients with cancer, putting the patient, rather than disease, at the center of the evaluation of safety of anti-cancer therapy. Hence, the implications of adverse events are described from the patient perspective, focusing on the impact of patient safety on quality of life and efficacy of treatment. Issues revolving around other types of safety, such as financial toxicity, are also discussed. The role played by genetics in the assessment of a patient’s risk of adverse events is also discussed, both in relation to the potential of genomic research and in the context of current tools of fruition in clinical care. |
| first_indexed | 2024-12-13T12:45:04Z |
| format | Article |
| id | doaj.art-6e999abdf8144f08970b189272ddedae |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-13T12:45:04Z |
| publishDate | 2017-03-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-6e999abdf8144f08970b189272ddedae2022-12-21T23:45:31ZengF1000 Research LtdF1000Research2046-14022017-03-01610.12688/f1000research.10475.111288Bringing a genomic perspective to the safety of drug treatment in oncology [version 1; referees: 3 approved]Federico Innocenti0Eshelman School of Pharmacy, Center for Pharmacogenomics and Individualized Therapy, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USAThis article describes the clinical relevance of toxicity of therapies administered to patients with cancer, putting the patient, rather than disease, at the center of the evaluation of safety of anti-cancer therapy. Hence, the implications of adverse events are described from the patient perspective, focusing on the impact of patient safety on quality of life and efficacy of treatment. Issues revolving around other types of safety, such as financial toxicity, are also discussed. The role played by genetics in the assessment of a patient’s risk of adverse events is also discussed, both in relation to the potential of genomic research and in the context of current tools of fruition in clinical care.https://f1000research.com/articles/6-385/v1Cancer TherapeuticsGenomicsMedical GeneticsPharmacogenomicsToxicology |
| spellingShingle | Federico Innocenti Bringing a genomic perspective to the safety of drug treatment in oncology [version 1; referees: 3 approved] F1000Research Cancer Therapeutics Genomics Medical Genetics Pharmacogenomics Toxicology |
| title | Bringing a genomic perspective to the safety of drug treatment in oncology [version 1; referees: 3 approved] |
| title_full | Bringing a genomic perspective to the safety of drug treatment in oncology [version 1; referees: 3 approved] |
| title_fullStr | Bringing a genomic perspective to the safety of drug treatment in oncology [version 1; referees: 3 approved] |
| title_full_unstemmed | Bringing a genomic perspective to the safety of drug treatment in oncology [version 1; referees: 3 approved] |
| title_short | Bringing a genomic perspective to the safety of drug treatment in oncology [version 1; referees: 3 approved] |
| title_sort | bringing a genomic perspective to the safety of drug treatment in oncology version 1 referees 3 approved |
| topic | Cancer Therapeutics Genomics Medical Genetics Pharmacogenomics Toxicology |
| url | https://f1000research.com/articles/6-385/v1 |
| work_keys_str_mv | AT federicoinnocenti bringingagenomicperspectivetothesafetyofdrugtreatmentinoncologyversion1referees3approved |