Risk factors associated with severe adverse events in patients with relapsing polychondritis undergoing flexible bronchoscopy
Abstract Background Patients with relapsing polychondritis (RP) sometimes experience upper airway collapse or lower airway stenosis, and bronchoscopy may provide a valuable typical image to confirm the diagnosis. This study aimed to identify potential risk factors associated with severe adverse effe...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Orphanet Journal of Rare Diseases |
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| Online Access: | https://doi.org/10.1186/s13023-024-03061-9 |
| _version_ | 1797273250497036288 |
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| author | Shao-Ting Wang Jinglan Wang Xiaoxing Gao Keqi Chen Kai-Feng Xu Xinlun Tian |
| author_facet | Shao-Ting Wang Jinglan Wang Xiaoxing Gao Keqi Chen Kai-Feng Xu Xinlun Tian |
| author_sort | Shao-Ting Wang |
| collection | DOAJ |
| description | Abstract Background Patients with relapsing polychondritis (RP) sometimes experience upper airway collapse or lower airway stenosis, and bronchoscopy may provide a valuable typical image to confirm the diagnosis. This study aimed to identify potential risk factors associated with severe adverse effects during bronchoscopy. Methods We performed a retrospective cohort study of 82 consecutive patients with RP hospitalized at Peking Union Medical College Hospital between January 1, 2012 and December 31, 2022. Clinical features and disease patterns were compared among patients with RP undergoing bronchoscopy with or without severe adverse effects. Binary logistic regression analysis was performed to identify the associated risk factors. Results For patients with RP undergoing bronchoscopy with severe adverse effects, the forced vital capacity (FVC), forced vital capacity percent predicted values (FVC%), and peak expiratory flow were significantly lower (P = 0.001, P = 0.001, and P = 0.021, respectively) than those in the non-severe adverse effect subgroup. Binary logistic regression analysis revealed that low FVC% (odds ratio, 0.930; 95% confidence interval, 0.880–0.982; P = 0.009) was an independent risk factor for severe adverse events in patients undergoing bronchoscopy. Conclusions Low FVC or FVC% suggests a high risk of severe adverse effects in patients with RP undergoing bronchoscopy. Patients with such risk factors should be carefully evaluated before bronchoscopy and adequately prepared for emergency tracheal intubation or tracheostomy. |
| first_indexed | 2024-03-07T14:41:44Z |
| format | Article |
| id | doaj.art-6e9bda092dc54a36add22f367e82d9d2 |
| institution | Directory Open Access Journal |
| issn | 1750-1172 |
| language | English |
| last_indexed | 2024-03-07T14:41:44Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Orphanet Journal of Rare Diseases |
| spelling | doaj.art-6e9bda092dc54a36add22f367e82d9d22024-03-05T20:20:28ZengBMCOrphanet Journal of Rare Diseases1750-11722024-02-011911710.1186/s13023-024-03061-9Risk factors associated with severe adverse events in patients with relapsing polychondritis undergoing flexible bronchoscopyShao-Ting Wang0Jinglan Wang1Xiaoxing Gao2Keqi Chen3Kai-Feng Xu4Xinlun Tian5Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesAbstract Background Patients with relapsing polychondritis (RP) sometimes experience upper airway collapse or lower airway stenosis, and bronchoscopy may provide a valuable typical image to confirm the diagnosis. This study aimed to identify potential risk factors associated with severe adverse effects during bronchoscopy. Methods We performed a retrospective cohort study of 82 consecutive patients with RP hospitalized at Peking Union Medical College Hospital between January 1, 2012 and December 31, 2022. Clinical features and disease patterns were compared among patients with RP undergoing bronchoscopy with or without severe adverse effects. Binary logistic regression analysis was performed to identify the associated risk factors. Results For patients with RP undergoing bronchoscopy with severe adverse effects, the forced vital capacity (FVC), forced vital capacity percent predicted values (FVC%), and peak expiratory flow were significantly lower (P = 0.001, P = 0.001, and P = 0.021, respectively) than those in the non-severe adverse effect subgroup. Binary logistic regression analysis revealed that low FVC% (odds ratio, 0.930; 95% confidence interval, 0.880–0.982; P = 0.009) was an independent risk factor for severe adverse events in patients undergoing bronchoscopy. Conclusions Low FVC or FVC% suggests a high risk of severe adverse effects in patients with RP undergoing bronchoscopy. Patients with such risk factors should be carefully evaluated before bronchoscopy and adequately prepared for emergency tracheal intubation or tracheostomy.https://doi.org/10.1186/s13023-024-03061-9Relapsing polychondritisRespiratory involvementSpirometryBronchoscopySevere adverse event |
| spellingShingle | Shao-Ting Wang Jinglan Wang Xiaoxing Gao Keqi Chen Kai-Feng Xu Xinlun Tian Risk factors associated with severe adverse events in patients with relapsing polychondritis undergoing flexible bronchoscopy Orphanet Journal of Rare Diseases Relapsing polychondritis Respiratory involvement Spirometry Bronchoscopy Severe adverse event |
| title | Risk factors associated with severe adverse events in patients with relapsing polychondritis undergoing flexible bronchoscopy |
| title_full | Risk factors associated with severe adverse events in patients with relapsing polychondritis undergoing flexible bronchoscopy |
| title_fullStr | Risk factors associated with severe adverse events in patients with relapsing polychondritis undergoing flexible bronchoscopy |
| title_full_unstemmed | Risk factors associated with severe adverse events in patients with relapsing polychondritis undergoing flexible bronchoscopy |
| title_short | Risk factors associated with severe adverse events in patients with relapsing polychondritis undergoing flexible bronchoscopy |
| title_sort | risk factors associated with severe adverse events in patients with relapsing polychondritis undergoing flexible bronchoscopy |
| topic | Relapsing polychondritis Respiratory involvement Spirometry Bronchoscopy Severe adverse event |
| url | https://doi.org/10.1186/s13023-024-03061-9 |
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