Inhibition of CpLIP2 Lipase Hydrolytic Activity by Four Flavonols (Galangin, Kaempferol, Quercetin, Myricetin) Compared to Orlistat and Their Binding Mechanisms Studied by Quenching of Fluorescence

Inhibition of CpLIP2 Lipase Hydrolytic Activity by Four Flavonols (Galangin, Kaempferol, Quercetin, Myricetin) Compared to Orlistat and Their Binding Mechanisms Studied by Quenching of Fluorescence

The inhibition of recombinant CpLIP2 lipase/acyltransferase from <i>Candida parapsiolosis</i> was considered a key model for novel antifungal drug discovery and a potential therapeutic target for candidiasis. Lipases have identified recently as potent virulence factors in <i>C. par...

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Bibliographic Details
Main Authors: Ruba Nasri, Luc P R Bidel, Nathalie Rugani, Véronique Perrier, Frédéric Carrière, Eric Dubreucq, Christian Jay-Allemand
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
recombinant CpLIP2 lipase
flavonols
orlistat
fluorescence quenching
inhibition
hydroxylation
tryptophan residues
docking
Online Access:https://www.mdpi.com/1420-3049/24/16/2888

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