Dietary inflammatory potential is associated with higher odds of hepatic steatosis in US adults: a cross-sectional study
Abstract Objective: Inflammation plays a critical role in the progression of chronic liver diseases, and diet can modulate inflammation. Whether an inflammatory dietary pattern is associated with higher risk of hepatic steatosis or fibrosis remains unclear. We aimed to investigate the associations...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2023-12-01
|
| Series: | Public Health Nutrition |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S1368980023001970/type/journal_article |
| _version_ | 1827578969189253120 |
|---|---|
| author | Hu Yang Tengfei Zhang Wen Song Zhaohong Peng Yu Zhu Yong Huang Xiude Li Zhuang Zhang Min Tang Wanshui Yang |
| author_facet | Hu Yang Tengfei Zhang Wen Song Zhaohong Peng Yu Zhu Yong Huang Xiude Li Zhuang Zhang Min Tang Wanshui Yang |
| author_sort | Hu Yang |
| collection | DOAJ |
| description |
Abstract
Objective:
Inflammation plays a critical role in the progression of chronic liver diseases, and diet can modulate inflammation. Whether an inflammatory dietary pattern is associated with higher risk of hepatic steatosis or fibrosis remains unclear. We aimed to investigate the associations between inflammatory dietary pattern and the odds of hepatic steatosis and fibrosis.
Design:
In this nationwide cross-sectional study, diet was measured using two 24-h dietary recalls. Empirical dietary inflammatory pattern (EDIP) score was derived to assess the inflammatory potential of usual diet, which has been validated to highly predict inflammation markers in the study population. Controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) were derived from FibroScan to define steatosis and fibrosis, respectively.
Setting:
US National Health and Nutrition Examination Survey.
Participants:
4171 participants aged ≥18 years.
Results:
A total of 1436 participants were diagnosed with S1 steatosis (CAP ≥ 274 dB/m), 255 with advanced fibrosis (LSM ≥ 9·7 kPa). Compared with those in the lowest tertile of EDIP-adherence scores, participants in the highest tertile had 74 % higher odds of steatosis (OR: 1·74, 95 % CI (1·26, 2·41)). Such positive association persisted among never drinkers, or participants who were free of hepatitis B and/or C. Similarly, EDIP was positively associated with CAP in multivariate linear model (P < 0·001). We found a non-significant association of EDIP score with advanced fibrosis or LSM (P = 0·837).
Conclusions:
Our findings suggest that a diet score that is associated with inflammatory markers is associated with hepatic steatosis. Reducing or avoiding pro-inflammatory diets intake might be an attractive strategy for fatty liver disease prevention.
|
| first_indexed | 2024-03-08T21:55:03Z |
| format | Article |
| id | doaj.art-6ea2b1706e3e4c68a29acef4199bd7ad |
| institution | Directory Open Access Journal |
| issn | 1368-9800 1475-2727 |
| language | English |
| last_indexed | 2024-03-08T21:55:03Z |
| publishDate | 2023-12-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Public Health Nutrition |
| spelling | doaj.art-6ea2b1706e3e4c68a29acef4199bd7ad2023-12-20T02:26:55ZengCambridge University PressPublic Health Nutrition1368-98001475-27272023-12-01262936294410.1017/S1368980023001970Dietary inflammatory potential is associated with higher odds of hepatic steatosis in US adults: a cross-sectional studyHu Yang0Tengfei Zhang1Wen Song2Zhaohong Peng3Yu Zhu4Yong Huang5Xiude Li6Zhuang Zhang7Min Tang8Wanshui Yang9https://orcid.org/0000-0002-7365-2689Department of Nutrition, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People’s Republic of China Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, People’s Republic of ChinaDepartment of Nutrition, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People’s Republic of ChinaDepartment of Interventional Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of ChinaDepartment of Interventional Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of ChinaDepartment of Nutrition, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People’s Republic of ChinaDepartment of Nutrition, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People’s Republic of ChinaDepartment of Nutrition, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People’s Republic of ChinaDepartment of Nutrition, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People’s Republic of ChinaDepartment of Gastroenterology and Hepatology and Clinical Nutrition, the Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of ChinaDepartment of Nutrition, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People’s Republic of China Abstract Objective: Inflammation plays a critical role in the progression of chronic liver diseases, and diet can modulate inflammation. Whether an inflammatory dietary pattern is associated with higher risk of hepatic steatosis or fibrosis remains unclear. We aimed to investigate the associations between inflammatory dietary pattern and the odds of hepatic steatosis and fibrosis. Design: In this nationwide cross-sectional study, diet was measured using two 24-h dietary recalls. Empirical dietary inflammatory pattern (EDIP) score was derived to assess the inflammatory potential of usual diet, which has been validated to highly predict inflammation markers in the study population. Controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) were derived from FibroScan to define steatosis and fibrosis, respectively. Setting: US National Health and Nutrition Examination Survey. Participants: 4171 participants aged ≥18 years. Results: A total of 1436 participants were diagnosed with S1 steatosis (CAP ≥ 274 dB/m), 255 with advanced fibrosis (LSM ≥ 9·7 kPa). Compared with those in the lowest tertile of EDIP-adherence scores, participants in the highest tertile had 74 % higher odds of steatosis (OR: 1·74, 95 % CI (1·26, 2·41)). Such positive association persisted among never drinkers, or participants who were free of hepatitis B and/or C. Similarly, EDIP was positively associated with CAP in multivariate linear model (P < 0·001). We found a non-significant association of EDIP score with advanced fibrosis or LSM (P = 0·837). Conclusions: Our findings suggest that a diet score that is associated with inflammatory markers is associated with hepatic steatosis. Reducing or avoiding pro-inflammatory diets intake might be an attractive strategy for fatty liver disease prevention. https://www.cambridge.org/core/product/identifier/S1368980023001970/type/journal_articleCross-sectional studyDietInflammationHepatic steatosisControlled attenuation parameter |
| spellingShingle | Hu Yang Tengfei Zhang Wen Song Zhaohong Peng Yu Zhu Yong Huang Xiude Li Zhuang Zhang Min Tang Wanshui Yang Dietary inflammatory potential is associated with higher odds of hepatic steatosis in US adults: a cross-sectional study Public Health Nutrition Cross-sectional study Diet Inflammation Hepatic steatosis Controlled attenuation parameter |
| title | Dietary inflammatory potential is associated with higher odds of hepatic steatosis in US adults: a cross-sectional study |
| title_full | Dietary inflammatory potential is associated with higher odds of hepatic steatosis in US adults: a cross-sectional study |
| title_fullStr | Dietary inflammatory potential is associated with higher odds of hepatic steatosis in US adults: a cross-sectional study |
| title_full_unstemmed | Dietary inflammatory potential is associated with higher odds of hepatic steatosis in US adults: a cross-sectional study |
| title_short | Dietary inflammatory potential is associated with higher odds of hepatic steatosis in US adults: a cross-sectional study |
| title_sort | dietary inflammatory potential is associated with higher odds of hepatic steatosis in us adults a cross sectional study |
| topic | Cross-sectional study Diet Inflammation Hepatic steatosis Controlled attenuation parameter |
| url | https://www.cambridge.org/core/product/identifier/S1368980023001970/type/journal_article |
| work_keys_str_mv | AT huyang dietaryinflammatorypotentialisassociatedwithhigheroddsofhepaticsteatosisinusadultsacrosssectionalstudy AT tengfeizhang dietaryinflammatorypotentialisassociatedwithhigheroddsofhepaticsteatosisinusadultsacrosssectionalstudy AT wensong dietaryinflammatorypotentialisassociatedwithhigheroddsofhepaticsteatosisinusadultsacrosssectionalstudy AT zhaohongpeng dietaryinflammatorypotentialisassociatedwithhigheroddsofhepaticsteatosisinusadultsacrosssectionalstudy AT yuzhu dietaryinflammatorypotentialisassociatedwithhigheroddsofhepaticsteatosisinusadultsacrosssectionalstudy AT yonghuang dietaryinflammatorypotentialisassociatedwithhigheroddsofhepaticsteatosisinusadultsacrosssectionalstudy AT xiudeli dietaryinflammatorypotentialisassociatedwithhigheroddsofhepaticsteatosisinusadultsacrosssectionalstudy AT zhuangzhang dietaryinflammatorypotentialisassociatedwithhigheroddsofhepaticsteatosisinusadultsacrosssectionalstudy AT mintang dietaryinflammatorypotentialisassociatedwithhigheroddsofhepaticsteatosisinusadultsacrosssectionalstudy AT wanshuiyang dietaryinflammatorypotentialisassociatedwithhigheroddsofhepaticsteatosisinusadultsacrosssectionalstudy |