Prognostic Role of ABO Blood Type in Operable Esophageal Cancer: Analysis of 2179 Southern Chinese Patients
BackgroundThe prognostic value of ABO blood types is not well clarified for esophageal carcinoma (EC). This study attempted to elucidate the associations between different ABO blood types and disease-free survival (DFS) and overall survival (OS) of EC.MethodsThis study was a retrospective review of...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-12-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.586084/full |
| _version_ | 1818947127848468480 |
|---|---|
| author | Shuishen Zhang Minghan Jia Xiaoli Cai Weixiong Yang Shufen Liao Zhenguo Liu Jing Wen Jing Wen Kongjia Luo Kongjia Luo Kongjia Luo Chao Cheng |
| author_facet | Shuishen Zhang Minghan Jia Xiaoli Cai Weixiong Yang Shufen Liao Zhenguo Liu Jing Wen Jing Wen Kongjia Luo Kongjia Luo Kongjia Luo Chao Cheng |
| author_sort | Shuishen Zhang |
| collection | DOAJ |
| description | BackgroundThe prognostic value of ABO blood types is not well clarified for esophageal carcinoma (EC). This study attempted to elucidate the associations between different ABO blood types and disease-free survival (DFS) and overall survival (OS) of EC.MethodsThis study was a retrospective review of the records of 2179 patients with EC who received surgery from December 2000 to December 2008. The prognostic impact of ABO blood group on DFS and OS were estimated using the Kaplan-Meier method and cox proportional hazard models.ResultsUnivariate analyses found significant differences in DFS and OS among the four blood types. Multivariate analyses showed ABO blood type independently predicted DFS (P=0.001) and OS (P=0.002). Furthermore, patients with non-B blood types had a significantly shorter DFS (HR=1.22, 95%CI:1.07–1.38, P=0.002) and OS (HR=1.22, 95%CI:1.07–1.38, P=0.003) than patients with blood type B, and patients with non-O blood types had a significantly better DFS (HR=0.86, 95%CI:0.77–0.96, P=0.006) and OS (HR=0.86, 95%CI:0.77–0.96, P=0.007) than patients with blood type O. Subgroup analyses found that blood type B had a better DFS and OS than non-B in patients who were male, younger, early pathological stages and had squamous-cell carcinomas (ESCC). Blood type O had a worse DFS and OS than non-O in patients who were male, younger, and had ESCC (P<0.05).ConclusionsThe results demonstrate that ABO blood group is an independent prognostic factor of survival, and that type B predicts a favorable prognosis, whereas type O predicts an unfavorable prognosis for survival in patients with EC, especially those with ESCC. |
| first_indexed | 2024-12-20T08:25:58Z |
| format | Article |
| id | doaj.art-6ea4300220214e2c81825c932489236e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T08:25:58Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-6ea4300220214e2c81825c932489236e2022-12-21T19:46:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-12-011010.3389/fonc.2020.586084586084Prognostic Role of ABO Blood Type in Operable Esophageal Cancer: Analysis of 2179 Southern Chinese PatientsShuishen Zhang0Minghan Jia1Xiaoli Cai2Weixiong Yang3Shufen Liao4Zhenguo Liu5Jing Wen6Jing Wen7Kongjia Luo8Kongjia Luo9Kongjia Luo10Chao Cheng11Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Breast Cancer, Guangdong Provincial People’s Hospital Cancer Center, Guangdong Academy of Medical Sciences, Guangzhou, ChinaDepartment of Medical Ultrasonics, First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaOperating room of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Esophageal Cancer Institute, Guangzhou, ChinaDepartment of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, ChinaGuangdong Esophageal Cancer Institute, Guangzhou, ChinaDepartment of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaBackgroundThe prognostic value of ABO blood types is not well clarified for esophageal carcinoma (EC). This study attempted to elucidate the associations between different ABO blood types and disease-free survival (DFS) and overall survival (OS) of EC.MethodsThis study was a retrospective review of the records of 2179 patients with EC who received surgery from December 2000 to December 2008. The prognostic impact of ABO blood group on DFS and OS were estimated using the Kaplan-Meier method and cox proportional hazard models.ResultsUnivariate analyses found significant differences in DFS and OS among the four blood types. Multivariate analyses showed ABO blood type independently predicted DFS (P=0.001) and OS (P=0.002). Furthermore, patients with non-B blood types had a significantly shorter DFS (HR=1.22, 95%CI:1.07–1.38, P=0.002) and OS (HR=1.22, 95%CI:1.07–1.38, P=0.003) than patients with blood type B, and patients with non-O blood types had a significantly better DFS (HR=0.86, 95%CI:0.77–0.96, P=0.006) and OS (HR=0.86, 95%CI:0.77–0.96, P=0.007) than patients with blood type O. Subgroup analyses found that blood type B had a better DFS and OS than non-B in patients who were male, younger, early pathological stages and had squamous-cell carcinomas (ESCC). Blood type O had a worse DFS and OS than non-O in patients who were male, younger, and had ESCC (P<0.05).ConclusionsThe results demonstrate that ABO blood group is an independent prognostic factor of survival, and that type B predicts a favorable prognosis, whereas type O predicts an unfavorable prognosis for survival in patients with EC, especially those with ESCC.https://www.frontiersin.org/articles/10.3389/fonc.2020.586084/fullesophageal cancerABO blood groupsurvivalprognostic factorlarge cohort |
| spellingShingle | Shuishen Zhang Minghan Jia Xiaoli Cai Weixiong Yang Shufen Liao Zhenguo Liu Jing Wen Jing Wen Kongjia Luo Kongjia Luo Kongjia Luo Chao Cheng Prognostic Role of ABO Blood Type in Operable Esophageal Cancer: Analysis of 2179 Southern Chinese Patients Frontiers in Oncology esophageal cancer ABO blood group survival prognostic factor large cohort |
| title | Prognostic Role of ABO Blood Type in Operable Esophageal Cancer: Analysis of 2179 Southern Chinese Patients |
| title_full | Prognostic Role of ABO Blood Type in Operable Esophageal Cancer: Analysis of 2179 Southern Chinese Patients |
| title_fullStr | Prognostic Role of ABO Blood Type in Operable Esophageal Cancer: Analysis of 2179 Southern Chinese Patients |
| title_full_unstemmed | Prognostic Role of ABO Blood Type in Operable Esophageal Cancer: Analysis of 2179 Southern Chinese Patients |
| title_short | Prognostic Role of ABO Blood Type in Operable Esophageal Cancer: Analysis of 2179 Southern Chinese Patients |
| title_sort | prognostic role of abo blood type in operable esophageal cancer analysis of 2179 southern chinese patients |
| topic | esophageal cancer ABO blood group survival prognostic factor large cohort |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.586084/full |
| work_keys_str_mv | AT shuishenzhang prognosticroleofabobloodtypeinoperableesophagealcanceranalysisof2179southernchinesepatients AT minghanjia prognosticroleofabobloodtypeinoperableesophagealcanceranalysisof2179southernchinesepatients AT xiaolicai prognosticroleofabobloodtypeinoperableesophagealcanceranalysisof2179southernchinesepatients AT weixiongyang prognosticroleofabobloodtypeinoperableesophagealcanceranalysisof2179southernchinesepatients AT shufenliao prognosticroleofabobloodtypeinoperableesophagealcanceranalysisof2179southernchinesepatients AT zhenguoliu prognosticroleofabobloodtypeinoperableesophagealcanceranalysisof2179southernchinesepatients AT jingwen prognosticroleofabobloodtypeinoperableesophagealcanceranalysisof2179southernchinesepatients AT jingwen prognosticroleofabobloodtypeinoperableesophagealcanceranalysisof2179southernchinesepatients AT kongjialuo prognosticroleofabobloodtypeinoperableesophagealcanceranalysisof2179southernchinesepatients AT kongjialuo prognosticroleofabobloodtypeinoperableesophagealcanceranalysisof2179southernchinesepatients AT kongjialuo prognosticroleofabobloodtypeinoperableesophagealcanceranalysisof2179southernchinesepatients AT chaocheng prognosticroleofabobloodtypeinoperableesophagealcanceranalysisof2179southernchinesepatients |