Nanometric Hydroxyapatite Particles as Active Ingredient for Bioinks: A Review
Additive manufacturing (AM), frequently cited as three-dimensional (3D) printing, is a relatively new manufacturing technique for biofabrication, also called 3D manufacture with biomaterials and cells. Recent advances in this field will facilitate further improvement of personalized healthcare solut...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Macromol |
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| Online Access: | https://www.mdpi.com/2673-6209/2/1/2 |
| _version_ | 1797445882067550208 |
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| author | Edilberto Ojeda África García-Barrientos Nagore Martínez de Cestafe José María Alonso Raúl Pérez-González Virginia Sáez-Martínez |
| author_facet | Edilberto Ojeda África García-Barrientos Nagore Martínez de Cestafe José María Alonso Raúl Pérez-González Virginia Sáez-Martínez |
| author_sort | Edilberto Ojeda |
| collection | DOAJ |
| description | Additive manufacturing (AM), frequently cited as three-dimensional (3D) printing, is a relatively new manufacturing technique for biofabrication, also called 3D manufacture with biomaterials and cells. Recent advances in this field will facilitate further improvement of personalized healthcare solutions. In this regard, tailoring several healthcare products such as implants, prosthetics, and in vitro models, would have been extraordinarily arduous beyond these technologies. Three-dimensional-printed structures with a multiscale porosity are very interesting manufacturing processes in order to boost the capability of composite scaffolds to generate bone tissue. The use of biomimetic hydroxyapatite as the main active ingredient for bioinks is a helpful approach to obtain these advanced materials. Thus, 3D-printed biomimetic composite designs may produce supplementary biological and physical benefits. Three-dimensional bioprinting may turn to be a bright solution for regeneration of bone tissue as it enables a proper spatio-temporal organization of cells in scaffolds. Different types of bioprinting technologies and essential parameters which rule the applicability of bioinks are discussed in this review. Special focus is made on hydroxyapatite as an active ingredient for bioinks design. The goal of such bioinks is to reduce the constraints of commonly applied treatments by enhancing osteoinduction and osteoconduction, which seems to be exceptionally promising for bone regeneration. |
| first_indexed | 2024-03-09T13:32:11Z |
| format | Article |
| id | doaj.art-6ea4368d58224b8ea715c52b960ef545 |
| institution | Directory Open Access Journal |
| issn | 2673-6209 |
| language | English |
| last_indexed | 2024-03-09T13:32:11Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Macromol |
| spelling | doaj.art-6ea4368d58224b8ea715c52b960ef5452023-11-30T21:16:34ZengMDPI AGMacromol2673-62092022-01-0121202910.3390/macromol2010002Nanometric Hydroxyapatite Particles as Active Ingredient for Bioinks: A ReviewEdilberto Ojeda0África García-Barrientos1Nagore Martínez de Cestafe2José María Alonso3Raúl Pérez-González4Virginia Sáez-Martínez5i+Med S. Coop., 01510 Vitoria-Gasteiz, Spaini+Med S. Coop., 01510 Vitoria-Gasteiz, Spaini+Med S. Coop., 01510 Vitoria-Gasteiz, Spaini+Med S. Coop., 01510 Vitoria-Gasteiz, Spaini+Med S. Coop., 01510 Vitoria-Gasteiz, Spaini+Med S. Coop., 01510 Vitoria-Gasteiz, SpainAdditive manufacturing (AM), frequently cited as three-dimensional (3D) printing, is a relatively new manufacturing technique for biofabrication, also called 3D manufacture with biomaterials and cells. Recent advances in this field will facilitate further improvement of personalized healthcare solutions. In this regard, tailoring several healthcare products such as implants, prosthetics, and in vitro models, would have been extraordinarily arduous beyond these technologies. Three-dimensional-printed structures with a multiscale porosity are very interesting manufacturing processes in order to boost the capability of composite scaffolds to generate bone tissue. The use of biomimetic hydroxyapatite as the main active ingredient for bioinks is a helpful approach to obtain these advanced materials. Thus, 3D-printed biomimetic composite designs may produce supplementary biological and physical benefits. Three-dimensional bioprinting may turn to be a bright solution for regeneration of bone tissue as it enables a proper spatio-temporal organization of cells in scaffolds. Different types of bioprinting technologies and essential parameters which rule the applicability of bioinks are discussed in this review. Special focus is made on hydroxyapatite as an active ingredient for bioinks design. The goal of such bioinks is to reduce the constraints of commonly applied treatments by enhancing osteoinduction and osteoconduction, which seems to be exceptionally promising for bone regeneration.https://www.mdpi.com/2673-6209/2/1/2additive manufacturing3D printingbioprintingbone cementshydroxyapatitebiomimetic |
| spellingShingle | Edilberto Ojeda África García-Barrientos Nagore Martínez de Cestafe José María Alonso Raúl Pérez-González Virginia Sáez-Martínez Nanometric Hydroxyapatite Particles as Active Ingredient for Bioinks: A Review Macromol additive manufacturing 3D printing bioprinting bone cements hydroxyapatite biomimetic |
| title | Nanometric Hydroxyapatite Particles as Active Ingredient for Bioinks: A Review |
| title_full | Nanometric Hydroxyapatite Particles as Active Ingredient for Bioinks: A Review |
| title_fullStr | Nanometric Hydroxyapatite Particles as Active Ingredient for Bioinks: A Review |
| title_full_unstemmed | Nanometric Hydroxyapatite Particles as Active Ingredient for Bioinks: A Review |
| title_short | Nanometric Hydroxyapatite Particles as Active Ingredient for Bioinks: A Review |
| title_sort | nanometric hydroxyapatite particles as active ingredient for bioinks a review |
| topic | additive manufacturing 3D printing bioprinting bone cements hydroxyapatite biomimetic |
| url | https://www.mdpi.com/2673-6209/2/1/2 |
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